Ozone therapy boosts gum disease treatment in small trial
NCT ID NCT05971706
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether adding ozone gas to standard deep-cleaning treatment helps people with gum disease (periodontitis). 18 healthy, non-smoking adults received standard cleaning on one side of the mouth and cleaning plus ozone on the other side. Researchers measured pocket depth, plaque, and inflammation to see if ozone improves results.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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18 people
The number who actually took part.
- Started
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Oct 2023
- Finished
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Oct 2024
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * systemically healthy * no periodontal treatment within 6 months from the enrollment date * no antibiotics or anti-inflammatory medication taken within 6 months from the enrollment date * no smokers * no pregnancy or lactation at the time of the stud * no contraindication for periodontal treatment and ozone application Exclusion Criteria: * Participants will be excluded if they had less than 20 teeth, partial dentures, or fixed prosthodontics.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Biruni University
Istanbul, Turkey (Türkiye)
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Other studies related to the condition(s) this trial covers.
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