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Gum inflammation linked to eye disease in small study

NCT ID NCT07480291

Knowledge-focused Sponsor: Selcuk University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
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Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
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Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compared gum health and levels of inflammatory substances in the mouth and blood of 25 people with non-infectious uveitis (an eye inflammation) and 27 healthy individuals. Researchers measured gum pocket depth, bleeding, and cytokines like TNF-α and IL-10. The goal was to see if gum disease and body-wide inflammation are connected to this eye condition.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

52 people

The number who actually took part.

Started

Oct 2020

Finished

Aug 2021

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

This cross-sectional study included adult individuals diagnosed with non-infectious uveitis (NIU) and systemically healthy controls. Participants were recruited from the outpatient clinic of the Department of Ophthalmology at Selcuk University. All participants underwent comprehensive periodontal examination and biofluid sampling, including gingival crevicular fluid, saliva, and serum, for cytokine analysis.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participants aged 18 years or older. * Patients diagnosed with non-infectious uveitis according to the * Standardization of Uveitis Nomenclature (SUN) criteria. * Presence of at least 20 natural teeth. * Individuals who agreed to participate in the study and provided informed consent. Exclusion Criteria: * Presence of infectious uveitis. * Pregnancy or lactation. * Use of antibiotics, anti-inflammatory drugs, or immunosuppressive therapy within the previous 6 months. * History of periodontal treatment within the previous 6 months. * Presence of systemic diseases known to affect periodontal status. * Current smokers.

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Conditions

The condition(s) this trial relates to.

non-infectious anterior uveitis periodontal disorder uveitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Non-infectious uveitis Periodontal disease

Contacts and locations

Locations

  • Selcuk University Faculty of Dentistry

    Konya, Konya, Turkey (Türkiye)

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