Could a Blood-Derived injection help heal gums after deep cleaning?

NCT ID NCT07029035

Completed Disease control Sponsor: Saglik Bilimleri Universitesi Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether injecting a substance made from a patient's own blood, called injectable platelet-rich fibrin (i-PRF), can improve gum healing after a deep dental cleaning. Twenty adults with advanced gum disease received i-PRF on one side of their mouth and a saltwater placebo on the other. Researchers measured gum pocket depth, attachment levels, and healing markers in gum fluid over three months to see if i-PRF boosts recovery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: injectable platelet-rich fibrin (i-PRF)
What this could lead to: If it works, this could point toward a new, natural treatment to improve gum healing after standard deep cleaning for periodontitis.
What could go wrong: This is a very small, early study (20 people) that only compared two sides of the mouth. Results may not apply to everyone, and the treatment may not show significant benefit over standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PERIODONTITIS STAGE III

Contacts and locations

Locations

Saglik Bilimleri Universitesi Gulhane Dis Hekimligi Fakultesi

Ankara, Turkey (Türkiye)

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