Could a needle-free gum treatment replace surgery for bone defects?
NCT ID NCT03797807
First seen Jun 29, 2026 · Last updated Jun 30, 2026 · Updated 1 time
Summary
This study compares two minimally invasive treatments for deep gum disease bone defects: a non-surgical approach (MINST) and a surgical one (MIST). Researchers want to see if the non-surgical method can achieve similar bone and gum attachment improvements as surgery, but with less discomfort. The trial involves 66 adults aged 25-70 with advanced periodontitis and at least one deep bone pocket. Participants are randomly assigned to one of the two treatments, and results are measured after 9 months using X-rays and clinical exams.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Minimally invasive non-surgical periodontal therapy (MINST) and minimally invasive surgical therapy (MIST)
What this could lead to
If MINST works as well as surgery, it could offer a less invasive, more comfortable option for treating deep gum disease bone defects.
What could go wrong
This is a small, single-center study, and the non-surgical approach may not prove as effective as surgery for all patients. Results may not apply to smokers or those with certain medical conditions.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Barts and The London Dental Hospital
London, E1 2AD, United Kingdom