Bleach strength during root canal retreatment may affect pain, study finds
NCT ID NCT07453576
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study looks at whether using different concentrations of sodium hypochlorite (a type of bleach) during root canal retreatment can change pain levels and certain nerve chemicals in the tooth. Sixty adults needing a repeat root canal will be randomly assigned to receive 1%, 2.5%, or 5% bleach irrigation. Researchers will measure pain after the procedure and test tooth fluid for substances linked to inflammation and pain. The goal is to find the best concentration to minimize discomfort.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Sodium hypochlorite (bleach) solution at 1%, 2.5%, or 5% concentration
- What this could lead to
- If successful, this could help dentists choose the best bleach concentration to reduce pain after root canal retreatment.
- What could go wrong
- This is a small, early-stage study with only 60 participants. It measures chemical markers, not direct pain relief, so results may not lead to clear treatment changes.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Atatürk University Faculty of Dentistry, Department of Endodontics
RECRUITINGErzurum, Erzurum, 25240, Turkey (Türkiye)
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