Can a Blood-Derived gel save infected teeth after failed root canals?
NCT ID NCT07448571
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares standard root canal retreatment with a regenerative method using injectable platelet-rich fibrin (i-PRF) in 140 adults with persistent tooth infections. Participants are randomly assigned to one of the two treatments and followed for two years to assess healing, pain, and tooth survival. The goal is to see if the regenerative approach leads to better outcomes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- injectable platelet-rich fibrin (i-PRF)
- What this could lead to
- If successful, this could offer a better way to heal persistent tooth infections after failed root canals, potentially saving more teeth.
- What could go wrong
- This is a relatively small, early-stage trial. The regenerative approach may not outperform standard retreatment, and long-term success is uncertain.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Marmara University
RECRUITINGIstanbul, Turkey (Türkiye)
Contact Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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