New hope for failed root canals: regenerative therapy tested in clinical trial

NCT ID NCT07448571

First seen Mar 05, 2026 · Last updated May 22, 2026 · Updated 12 times

Summary

This study compares a new regenerative approach using injectable platelet-rich fibrin (i-PRF) to standard retreatment for teeth with persistent infection after a root canal. 140 adults with single-rooted front teeth will be randomly assigned to one of the two treatments and followed for two years. The goal is to see if the regenerative method leads to better healing, less pain, and longer tooth survival.

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Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Marmara University

    RECRUITING

    Istanbul, Turkey (Türkiye)

    Contact Email: •••••@•••••

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

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