Can insulin help heal gums? a trial puts it to the test
NCT ID NCT07746206
First seen Aug 04, 2026 · Last updated Aug 05, 2026 · Updated 1 time
Summary
This trial tests whether applying insulin or hyaluronic acid gel directly into gum pockets, alongside standard deep cleaning, improves healing in people with stage III periodontitis. About 45 adults with gum disease will receive one of the two gels or cleaning alone, and researchers will measure changes in pocket depth, gum attachment, and markers of inflammation. The goal is to see if these topical treatments can boost the effects of non-surgical gum therapy.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Insulin gel or hyaluronic acid gel applied directly into gum pockets after deep cleaning
- What this could lead to
- If it works, this could point toward a simple, affordable way to improve gum healing and reduce pocket depth in people with advanced periodontitis.
- What could go wrong
- This is a very early, small trial, so results may not hold up in larger studies. Insulin applied to gums could also cause low blood sugar or other local effects, though risks are likely low.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Alazhar university
RECRUITINGCairo, Egypt
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Faculty of Dental Medicine for Girls, Al-Azhar University
RECRUITINGCairo, Egypt