Gum disease repair: which bone graft works best?
NCT ID NCT07546279
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests two different bone graft materials—one from cow bone and one synthetic—combined with a special enamel protein to repair deep gum and bone defects caused by periodontitis. Forty adults with at least one deep gum pocket (6 mm or more) and a bone defect will receive microsurgery to place the graft. The main goal is to see which material reduces pocket depth more after 12 months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- enamel matrix derivative (EMD) plus either bovine bone graft (BioOss Collagen) or a synthetic hydroxyapatite collagen sponge (Ossix Bone)
- What this could lead to
- If successful, this could show which bone graft material works better alongside EMD to repair gum and bone damage from periodontitis, potentially improving treatment outcomes.
- What could go wrong
- This is a small, early-stage trial with only 40 participants, so results may not apply to everyone. The study compares two materials but does not include a placebo group, making it harder to know if either is truly better than standard care.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for BONE DEFECTS are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
IRCCS Ospedale Galeazzi-Sant'Ambrogio
RECRUITINGMilan, Italy
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Blood-Derived clot may regrow bone in gum disease
- Can gum disease be stopped by targeting these genes?
- Could saliva hold the key to understanding gum disease?
- Can a gentler Deep-Clean beat standard gum therapy?
- Could a toothpaste ingredient reshape the microbes behind gum disease?
- Could Stressed-Out gum cells be behind periodontitis?