Toothache relief: could a common painkiller beat standard root canal medicine?
NCT ID NCT07237620
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares two medications placed inside the tooth after a failed root canal: standard calcium hydroxide and the painkiller diclofenac sodium. Sixty patients with persistent infection around the tooth root will be randomly assigned to one of the two treatments. Healing will be measured by changes in bone patterns on X-rays taken before and 12 months after treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
calcium hydroxide and diclofenac sodium
What this could lead to
If this works, it could show that diclofenac sodium is a better option than standard calcium hydroxide for healing bone around the tooth root after a failed root canal.
What could go wrong
This is a small, early-phase study with only 60 patients, so results may not apply to everyone. The main measure is a change in bone pattern on X-rays, not a direct symptom check, and the 12-month follow-up may not capture long-term outcomes.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for APICAL PERIODONTITIS are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
Merve Sarı
RECRUITINGHatay, Antakya, 31060, Turkey (Türkiye)
Contact Phone: •••-•••-•••• Email: •••••@•••••