DIABETES MELLITUS (TYPE 2)

This study tests whether spermidine, a natural substance found in foods like soy and aged cheese, can improve heart and muscle health in elderly people with coronary artery disease. 180 participants aged 65 and older will receive either spermidine capsules or a placebo for a peri…

This study tests a new procedure called ReCET that uses gentle electrical pulses to regenerate the lining of the small intestine. Combined with a diabetes drug (semaglutide), the goal is to help people with type 2 diabetes stop using insulin. The study involves 32 adults and comp…

This study tests a 6-week online group program designed to help African American women with type 2 diabetes reduce diabetes-related distress and improve blood sugar control. The program combines diabetes education, motivational interviewing, and cognitive behavioral therapy, deli…

This completed study tested whether a customizable texting program could help veterans with type 2 diabetes improve their blood sugar control. 366 veterans were randomly assigned to receive either standard daily diabetes texts or a more interactive version with check-ins, medicat…

This study tested whether giving adults with type 2 diabetes and food insecurity a small weekly incentive ($10.50 per household member) to buy healthy foods could improve their blood sugar control. 597 participants were randomly assigned to receive either the food incentive plus …

This study tested a new medicine called survodutide (BI 456906) to see if it helps people with overweight or obesity and type 2 diabetes lose weight. Over 750 adults received either the drug or a placebo injection once a week for about 76 weeks, along with diet and exercise advic…

This study looked at whether delivering healthy food to the homes of rural adults with type 2 diabetes and food insecurity could improve their blood sugar control and diet. Over 400 participants either received standard care alone or standard care plus free healthy food deliverie…

This trial tests whether a family-centered diabetes education program helps people with type 2 diabetes manage their blood sugar better than standard education. About 1,100 adults with type 2 diabetes and their family members take part. Participants are randomly assigned to eithe…

This study tested whether a team of specialists—an endocrinologist, diabetes educator, and dietician—could help people with type 2 diabetes and heart disease control their blood sugar better than standard care. 169 patients were split into two groups: one received usual care from…

This study tested whether a smartphone app that lets people log their blood sugar readings at home can improve diabetes control. One hundred adults with poorly controlled type 2 diabetes used the app or continued usual care for 3 months. Researchers measured changes in HbA1c, a k…

This study tested a new insulin called icodec that is injected just once a week, compared to standard daily insulin shots, in over 1,000 adults with type 2 diabetes who had never used insulin before. The goal was to see if the weekly shot controls blood sugar just as well as dail…

This study tested a new insulin called icodec, taken just once a week, against a standard daily insulin (degludec) in 588 adults with type 2 diabetes who had never used insulin before. Participants received either weekly icodec plus a daily placebo, or daily degludec plus a weekl…

This study tested a new once-a-week injection called IcoSema, which combines insulin and semaglutide, against semaglutide alone in 683 adults with type 2 diabetes. The goal was to see if IcoSema improves blood sugar levels more effectively. Participants received weekly shots for …

This study looked at how safe a new once-weekly insulin (insulin icodec) is during exercise and long periods without food in 30 adults with type 2 diabetes. Participants first took a daily insulin for a week, then switched to the weekly insulin for up to 14 weeks. The goal was to…

This early study tested a single injection of a new drug called ENT-03S in 49 people who were either obese but otherwise healthy, or had both obesity and type 2 diabetes. The main goal was to check safety and how the drug moves through the body. Participants were randomly assigne…

This study tested whether eating all meals earlier in the day and getting bright light therapy at specific times can improve blood sugar control in adults with type 2 diabetes. Researchers measured blood sugar, insulin, and other health markers in 190 participants. The goal was t…

This completed Phase 3 study tested whether adding semaglutide to a new once-weekly insulin (insulin icodec) improves blood sugar control in 148 adults with type 2 diabetes. Participants first received insulin icodec alone for 26 weeks; those with still-high blood sugar then adde…

This early-stage study tested an oral drug called LY3502970 in 68 adults with type 2 diabetes. The main goal was to check safety and side effects, while also measuring how the drug moves through the body and affects blood sugar. Participants took the drug or a placebo for up to 1…

This completed study followed more than 3,200 Japanese adults with type 2 diabetes who were prescribed Ozempic (semaglutide) by their doctors. Over about 3 years, researchers monitored side effects and checked how well the drug controlled blood sugar and weight. The goal was to s…

This study tested whether using activity trackers, text reminders, and short exercise videos could help people with type 2 diabetes reduce the time they spend sitting at work. Forty-six adults with type 2 diabetes who had mostly desk jobs took part. The goal was to see if these m…

This study tested whether a daily postbiotic capsule (a substance that helps good gut bacteria) could improve blood sugar control in adults with type 2 diabetes. 106 participants took either the postbiotic or a placebo for 12 weeks. Researchers also analyzed genetics and gut bact…

This study looked at whether a daily prebiotic supplement (Molkosan®) could improve blood sugar and other health markers in people with type 2 diabetes. Twelve adults took a low dose (20 ml per day) for 12 weeks. Researchers measured changes in glucose tolerance, insulin levels, …

This study looked at whether a DASH-style diet (modified for diabetes) combined with lower salt intake can lower blood pressure in adults with type 2 diabetes and high blood pressure. 105 participants ate specially prepared meals for 5-week periods. The goal was to find a practic…

This completed study tested whether lotus seed capsules could improve nerve health, blood sugar, and immune function in 60 people with type 2 diabetes and nerve damage. Participants took either lotus seed or placebo capsules for 9 months alongside their regular diabetes treatment…

This study tested whether adding a weekly semaglutide injection to a lower dose of insulin works as well as a higher dose of insulin alone for controlling blood sugar in people with type 2 diabetes who are overweight. About 573 adults took part for roughly 11 months. The goal was…

This pilot study tested a mobile app and wearable devices to give personalized diet and activity advice to 27 adults with type 2 diabetes or prediabetes. The goal was to see if the app could help them improve their blood sugar levels and make healthier food choices. The study als…

This study tested whether giving Hispanic teenagers a Fitbit and sending them text messages could help them be more active and sleep better. The goal was to reduce their risk of type 2 diabetes. 43 teens aged 14-16 with obesity took part. The study measured how many teens joined,…

This study tested whether a dietary supplement called phosphatidylserine can improve blood flow in people with type 2 diabetes. 36 adults took either the supplement or a placebo for 4 weeks. Researchers measured blood flow in the leg and arm to see if the supplement helped blood …

This study tested whether helping people with type 2 diabetes address unmet basic needs—like food, housing, and safety—can improve their blood sugar control. About 473 adults on Medicaid received either a 6-month navigation program or usual care. The goal was to see if this suppo…

This study tested a new approach for people with type 2 diabetes: a once-weekly insulin injection (insulin icodec) combined with a flash glucose monitor, a small sensor worn on the arm that tracks blood sugar continuously. The goal was to see if this combination helps control blo…

This completed Phase 3 trial tested a high 7.2 mg weekly dose of semaglutide (a drug already used for diabetes and weight loss) in 512 adults with obesity and type 2 diabetes. Participants received either the high dose, a lower dose, or a placebo, along with lifestyle counseling.…

This study tested whether providing medically tailored meals (10 ready-to-eat meals per week for 6 months) plus phone-based lifestyle coaching could improve blood sugar control in adults with type 2 diabetes who also face food insecurity. 215 participants were randomly assigned t…

This study tested a virtual health program for African immigrants aged 25-75 who had at least two risk factors like diabetes, high blood pressure, or obesity. Participants used Bluetooth scales and blood pressure monitors to track their health over 6 months. The program was deliv…

This study tested three different diabetes treatments in 186 overweight or obese adults newly diagnosed with type 2 diabetes. Participants received either empagliflozin plus metformin, sitagliptin plus metformin, or metformin alone for 12 weeks. Researchers measured changes in bl…

This study tested whether a six-week empowerment-based health education program could improve self-management in 50 adults with type 2 diabetes. Participants learned about diabetes, diet, and physical activity through group activities and discussions. The goal was to see if this …

This study looked at how safe and effective Fiasp, a faster-acting mealtime insulin, is for people with type 1 or type 2 diabetes in everyday life. 42 adults used Fiasp as prescribed by their doctor for about 6 months. Researchers tracked side effects and blood sugar control to s…

This study tested a new medicine (NNC0480-0389) combined with semaglutide, a common diabetes drug, in 500 people with type 2 diabetes. Participants received weekly injections for about 41 weeks. The goal was to see how well the combination lowers blood sugar and to pick the best …

This study tested a new fast-acting insulin called NNC0471-0119 in 65 adults with type 2 diabetes who use an insulin pump. Researchers compared how quickly the new insulin enters the bloodstream and lowers blood sugar versus a standard insulin (insulin aspart). The goal is to see…

This study looked at whether high-intensity interval training (HIIT) can improve blood sugar control and insulin sensitivity in women with type 2 diabetes, comparing effects before and after menopause. Sixty women aged 40-65 completed an 8-week supervised HIIT program. Researcher…

This early-stage study tested a new medicine, NNC0519-0130, in 20 overweight or obese Chinese men. The goal was to see how the drug moves through the body and if it is safe. Participants received either the drug or a placebo for about 28 weeks. This is not a cure, but aims to hel…

This small safety study tested a new artificial intelligence system called FUSION that automatically controls blood sugar levels in people with type 2 diabetes. Three participants who use insulin at home had their glucose managed by the device for 24 hours while eating standard m…

This study tested whether taking a daily probiotic drink called Goodbelly for 6 weeks could improve blood vessel function and reduce inflammation in 215 adults with heart disease or type 2 diabetes. Researchers measured blood markers and gut bacteria to see if the probiotic made …

This study tested whether personalized text messages can improve medication adherence in adults with type 2 diabetes. 28 participants received either tailored or generic daily texts for 6 months. The goal was to see if custom messages help people take their diabetes pills more co…

This study compared two exercise programs—periodized circuit training and conventional strength training—in 50 adults with type 2 diabetes. Over 6 weeks, researchers measured changes in heart and lung fitness, quality of life, and blood sugar control. The goal was to see which ap…

This pilot study tested a web-based version of the DECIDE program, called eDECIDE, which teaches problem-solving skills to help African Americans manage type 2 diabetes. The study involved 36 participants and compared the online program to the traditional in-person group sessions…

This study tested whether adding pioglitazone or dapagliflozin to standard diabetes pills (alogliptin and metformin) helps control blood sugar better in adults with type 2 diabetes. A total of 133 participants took one of the two extra drugs for 26 weeks. The main goal was to see…

This study tested whether a daily pill called oral semaglutide helps children and teenagers (ages 10 to under 18) with type 2 diabetes control their blood sugar better than a placebo. All participants also took standard diabetes medicines like metformin or insulin. The trial last…

This study tested whether a program that combines technology (like a monitoring system) with diabetes education and skills training can help African American adults with poorly controlled type 2 diabetes. About 200 participants used the system for 12 months, and researchers measu…

This study looked at whether a special dietary supplement could help heal foot ulcers in people with diabetes and prevent the need for amputation. 35 adults with diabetes and foot ulcers were observed for 6 weeks while using the supplement at home. The main goals were to see how …

This study tested the drug dapagliflozin (a diabetes medicine) against a placebo in 220 people on dialysis for kidney failure, with or without diabetes. The goal was to see if the drug could improve heart structure and be safe. Participants took the drug or placebo for a period, …

This completed Phase 1 trial tested CagriSema, a new combination of two medicines (cagrilintide and semaglutide), in 158 adults with type 2 diabetes. Participants received either CagriSema, one of the individual drugs, or a placebo, alongside their usual metformin. The study meas…

This study tested whether people with type 2 diabetes and kidney damage can safely participate in a clinical trial from home. Twelve participants took the drug empagliflozin, and depending on their response, some added or switched to finerenone. The goal was to see if remote data…

This study tested whether a smartphone app helps people with type 2 diabetes stick with their weekly Ozempic injections. 304 participants either used the app or received standard care. The study tracked how long they stayed on the medication and if they reached their target dose.

This study tested an automated insulin delivery system (a smart pump) in 15 adults with type 1 or type 2 diabetes who also had advanced kidney disease or were on dialysis. Participants used the system for 8 weeks, then switched to their usual care for another 8 weeks. The goal wa…

This study tested a special diabetes clinic within a primary care setting for patients with poorly controlled type 2 diabetes. The clinic brought together doctors, diabetes educators, nurses, behavioral health providers, and social workers to offer comprehensive care, including c…

This completed study looked at over 28,000 people with type 2 diabetes and a type of heart failure called HFpEF. Researchers compared two drugs, tirzepatide and semaglutide, to see which one better reduces the risk of death or hospitalization for heart failure. The study used rea…

This completed study tested whether a health behavior program designed with input from immigrant communities can improve diabetes management in first-generation immigrants with type 2 diabetes. Researchers compared the culture-sensitive program to standard care in 202 participant…

This study tested a once-weekly injection of semaglutide (2.4 mg) to help people with overweight or obesity lose weight. About 375 adults took part, some receiving the drug and others a placebo, along with lifestyle advice. The main goal was to see how much weight they lost over …

This 16-week study tested whether a low-fat vegan diet can improve insulin sensitivity and blood sugar control in people with type 2 diabetes. Twenty-six adults with type 2 diabetes and a BMI between 26 and 40 participated. They received weekly nutrition classes and one-on-one di…

This study tested whether weekly home delivery of diabetes-friendly food boxes, along with easy-to-understand diabetes education materials, could improve health in 101 low-income adults with type 2 diabetes who also faced food insecurity. Participants received the food boxes and …

This completed study tested a community-based program for people with type 2 diabetes. Participants received diabetes education, dietary counseling, physical and occupational therapy, and help with social needs like finances and mental health. The goal was to see if this approach…

This study tested a new medicine called AZD5004 in 406 adults with type 2 diabetes. The goal was to see if it helps lower blood sugar better than a placebo or an existing diabetes drug. Participants had to have had diabetes for at least 6 months and be on diet, exercise, or stabl…

This study looked at whether weight-loss surgery (vertical sleeve gastrectomy) can improve kidney, heart, and pancreas function in teens aged 12-21 with type 2 diabetes and obesity. Researchers measured blood flow to the kidneys, kidney filtering ability, and insulin production b…

This study looked at whether a mobile app called 'Dose Check' helps people with type 2 diabetes control their blood sugar when used with the insulin Tresiba. 179 adults in Saudi Arabia used the app alongside their regular insulin for about 6-7 months. Researchers measured changes…

This study looked at whether taking probiotics alongside regular diabetes medications can improve blood sugar, cholesterol, and inflammation in adults with type 2 diabetes. Researchers enrolled 77 people aged 35-65. The goal was to see if changing gut bacteria with probiotics cou…

This study tested whether personalized, automatic coaching messages based on continuous glucose monitor readings and mood assessments could help people with insulin-treated type 2 diabetes improve their blood sugar control. 46 adults participated over 12 weeks. The goal was to se…

This study followed 50 adults with type 2 diabetes who were already prescribed oral semaglutide (Rybelsus) by their doctor. Researchers tracked changes in blood sugar (HbA1c) and body weight over about 8-10 months. Participants also filled out a questionnaire about how they took …

This study followed 244 adults with type 2 diabetes in Japan who were already prescribed Xultophy by their doctor. Researchers tracked blood sugar levels and low blood sugar episodes over 26 weeks to see how well the treatment works in everyday life. The goal was to understand re…

This early-stage study tested a new medicine, NNC0519-0130, given as a weekly injection to help people with obesity or type 2 diabetes. The main goals were to check for side effects and measure how the drug moves through the body. 82 participants were randomly assigned to get eit…

This study tested a new medicine called NNC0519-0130 in 299 adults with type 2 diabetes. The goal was to see if a once-weekly injection can lower blood sugar and body weight. Participants received up to 7 different doses for about 40 weeks. The results will help find the best dos…

This study looked at how safe and effective Xultophy (a combination of two diabetes drugs) is for adults with type 2 diabetes when used in everyday medical practice in Korea. About 750 people took part, and the study lasted 26 weeks. The goal was to track side effects and measure…

This completed study looked at how well oral semaglutide (Rybelsus) works for Thai adults with type 2 diabetes in everyday medical practice. Researchers reviewed medical records of 209 patients over 6 months to measure changes in blood sugar (HbA1c) and body weight. The goal was …

This study tested a program that helps low-income African Americans with diabetic kidney disease get their basic needs, like food and housing, while also providing lifestyle coaching. Fifty participants received one-on-one sessions and a device to track blood sugar and blood pres…

This study looked at whether adding community health workers to regular care helps people with type 2 diabetes and high blood pressure in rural Mexico take their medicines as prescribed. 168 adults from local clinics took part. Researchers measured changes in blood sugar and bloo…

This study tested whether combining two injectable drugs, cagrilintide and semaglutide, works better than either drug alone for lowering blood sugar in people with type 2 diabetes. 92 adults with type 2 diabetes and a BMI of 27 or higher took part. Participants received weekly in…

This early study tested a device that uses mild electric pulses to regenerate the lining of the upper small intestine in 20 adults with type 2 diabetes. The goal was to see if the procedure is safe and could help lower blood sugar. Participants were on 2-3 diabetes pills and had …

This study tested whether an intelligent insulin-dosing decision support system could help adults with type 2 diabetes manage their blood sugar better than standard care. 140 participants starting insulin therapy used a smart glucometer and mobile app to get algorithm-based dose …

This study tested a new insulin called icodec that is injected just once a week, compared to a standard daily insulin (degludec), in 526 adults with type 2 diabetes. The goal was to see if the weekly insulin controls blood sugar as well as the daily one over 26 weeks. Participant…

This study tested whether an AI-powered health coach and gamification could help people with type 2 diabetes better manage their blood sugar. 88 participants in rural areas received weekly automated coaching calls and goal-setting. The main goal was to see if this approach is fea…

This study tested three different doses of semaglutide (2 mg, 8 mg, and 16 mg) in 245 adults with type 2 diabetes and overweight who were already taking metformin. The main goals were to see how well each dose lowered blood sugar and body weight over 40 weeks. Participants receiv…

This study tested whether the drug Entresto (LCZ 696) can improve how the kidneys and heart handle extra salt and fluid in people with type 2 diabetes. Some participants had early signs of heart stiffness (diastolic dysfunction) and others did not. The goal was to see if the drug…

This study tested whether a new way of making semaglutide works as well as the current version for controlling blood sugar in people with type 2 diabetes. 388 participants received weekly injections for about 8 months. The main goal was to compare changes in HbA1c levels between …

This study tested whether higher doses (25 mg and 50 mg) of once-daily oral semaglutide work better than the standard 14 mg dose in people with type 2 diabetes. Over 1,600 adults took part, gradually increasing their dose over 68 weeks. The main goals were to see changes in blood…

This study looked at whether semaglutide, a type 2 diabetes medicine, can reduce the risk of major heart problems like heart attacks, strokes, or heart-related death. About 9,600 adults with type 2 diabetes and existing heart disease took either semaglutide tablets or a placebo d…

This study looked at how well the diabetes pill Rybelsus (oral semaglutide) works in everyday life for adults with type 2 diabetes in Canada. About 194 people took the medication as prescribed by their doctor and filled out questionnaires over 8-10 months. The main goal was to se…

This study tested a new fast-acting insulin (faster aspart) against a standard insulin (NovoRapid) in 331 adults with type 1 or type 2 diabetes. Both were taken with a long-acting insulin (insulin degludec) for 16 weeks. The goal was to see if the new insulin works better at cont…

This study tested a new once-weekly medicine called IcoSema (a mix of two drugs) against daily insulin injections in 679 adults with type 2 diabetes. Participants received either IcoSema once a week or daily insulin plus mealtime insulin for 52 weeks. The goal was to see if the w…

This study tested a new insulin called icodec that is injected just once a week, compared to a standard daily insulin (glargine), in 582 adults with type 2 diabetes. Participants also used mealtime insulin as needed. The goal was to see if the weekly insulin controls blood sugar …

This study tested a new once-weekly injection called IcoSema, which combines insulin icodec and semaglutide, against once-weekly insulin icodec alone in over 1,200 people with type 2 diabetes. The goal was to see if the combo improves blood sugar control more effectively. Partici…

This study looked at how quickly a fast-acting insulin (faster aspart) enters the blood in 23 Chinese adults with type 1 or type 2 diabetes. Participants received one injection of faster aspart and one of the standard insulin NovoRapid, in random order. Blood samples were taken o…

This study tested whether a daily 30-minute foot exercise program could improve blood flow in the legs of 44 adults with type 2 diabetes. After 3 months, those who did the exercises had better circulation, measured by ankle-brachial index, compared to a control group. The exercis…

This study tested a new insulin called icodec that is injected just once a week, compared to a standard daily insulin (glargine), in nearly 1,000 adults with type 2 diabetes who had never used insulin before. The main goal was to see if the weekly insulin could control blood suga…

This completed study compared the effectiveness of once-daily oral semaglutide (Rybelsus) to other oral diabetes medications in 1020 adults with type 2 diabetes who were already taking metformin. Participants were randomly assigned to receive either Rybelsus or another diabetes p…

This study tested whether using mobile monitoring devices along with nurse support can help people better manage type 2 diabetes and high blood pressure. 220 adults with poor diabetes control took part. The program focused on teaching self-management skills like tracking blood su…

This study tested a smartphone app called My Diabetes Care that uses simple graphics to help people with type 2 diabetes understand their health numbers (like blood sugar and cholesterol) and gives tips for self-care. 458 adults from two hospitals used the app or got usual care. …

This study looked at whether using a continuous glucose monitor and working with a clinical pharmacist can improve blood sugar control in uninsured Black and Hispanic patients with type 2 diabetes. Twenty participants used the monitor and received medication management from a pha…

This study tested whether using wireless continuous glucose monitors (CGM) in the hospital can help manage blood sugar levels for people with type 1 or high-risk type 2 diabetes. 157 patients wore the monitors, which sent real-time glucose readings to a care team that could adjus…

This study tested the safety of Lyumjev, a rapid-acting insulin, in 150 adults with type 2 diabetes in India. Participants used Lyumjev along with their usual long-acting insulin for 26 weeks. The main goal was to see how many people had low blood sugar episodes. The study is alr…

This study looked at whether adding dapagliflozin to metformin helps people with prediabetes or type 2 diabetes and severe obesity lose more weight than metformin alone. About 160 participants took either both drugs or just metformin for up to 12 months. The main goal was to see …

This study looked at how well once-daily oral semaglutide (Rybelsus) works for adults with type 2 diabetes in everyday medical practice in Israel. Researchers tracked changes in blood sugar and body weight over about 8-10 months. The goal was to see if the pill helps lower blood …

This study looked at whether a special nutritional drink called Resource Diabet Plus can improve blood sugar and cholesterol levels in people with type 2 diabetes who are malnourished or at risk of malnutrition. Researchers reviewed medical records of 59 patients in Spain who too…

This study tested whether intermittent fasting (eating only within a 4-hour window each day) can improve how well the pancreas makes insulin in people with early type 2 diabetes. 51 adults with type 2 diabetes and obesity took part. The goal was to see if this eating pattern coul…

This study followed 291 adults with type 2 diabetes whose blood sugar was not well controlled on their current medication (DPP4i). Participants switched to an oral version of semaglutide, a drug that helps lower blood sugar and may aid weight loss. Over about 5-6 months, research…

This study tested whether colostrum (a supplement from cow's first milk) could improve physical performance and thinking skills in people with type 2 diabetes and healthy adults. About 80 participants took either colostrum or a placebo daily for 60 days. Researchers measured bloo…

This study tested whether providing medically tailored meals and nutrition counseling via telehealth can improve blood sugar control in adults with poorly controlled type 2 diabetes. 600 participants were randomly assigned to receive meals, meals plus counseling, or usual care. T…

This study tested the safety and tolerability of a once-weekly injection of semaglutide (0.5 or 1.0 mg) in 104 Chilean adults with type 2 diabetes over 24 weeks. Participants received the drug in escalating doses, with regular blood and urine tests to monitor side effects. The ma…

This study looked at how well the diabetes pill Rybelsus (oral semaglutide) works in real life for adults with type 2 diabetes in Sweden. Researchers tracked blood sugar levels and weight changes over 8-10 months in 194 people who were already prescribed the medication by their d…

This study followed 145 adults with type 2 diabetes who took once-daily oral semaglutide (Rybelsus) as part of their normal care. Researchers measured changes in blood sugar (HbA1c) and body weight over 8-10 months. The goal was to see how well the medication works in everyday li…

This study tested whether adding oral diabetes drugs (metformin/pioglitazone or sitagliptin) to a short-term insulin pump can improve long-term blood sugar control and help newly diagnosed type 2 diabetes patients achieve remission. 264 participants who were newly diagnosed, not …

This study looked at how well once-daily oral semaglutide (Rybelsus) works for adults with type 2 diabetes in everyday UK clinics. Researchers tracked blood sugar levels and weight changes over 8-10 months in 336 participants. The goal was to see if the pill helps lower blood sug…

This study followed 99 adults with type 2 diabetes in Denmark who were already prescribed once-daily oral semaglutide (Rybelsus). Researchers tracked changes in blood sugar (HbA1c) and body weight over 8-10 months, along with patient questionnaires. The goal was to see how well t…

This study tested a medication called tirzepatide in children and teenagers aged 10 to 17 with type 2 diabetes. Participants were already taking metformin or insulin but still had high blood sugar. The goal was to see if tirzepatide could safely lower blood sugar levels better th…

This study looked at how well once-daily oral semaglutide (Rybelsus) works for adults with type 2 diabetes in Mexico. Researchers tracked changes in blood sugar and body weight over 8-10 months. The goal was to see if this pill helps lower blood sugar levels in everyday clinical …

This completed study looked at how well once-daily oral semaglutide (Rybelsus) works for adults with type 2 diabetes in real-world clinics across Spain. Researchers tracked changes in blood sugar (HbA1c), body weight, and how satisfied patients were with their treatment over 8-10…

This completed study in Italy looked at how well once-daily oral semaglutide (Rybelsus) works for adults with type 2 diabetes in everyday medical practice. Researchers tracked changes in blood sugar and body weight over 8-10 months in 458 participants. The goal was to see if this…

This study looked at how well once-daily oral semaglutide (Rybelsus) works for adults with type 2 diabetes in everyday clinical practice in Saudi Arabia. Researchers tracked changes in blood sugar (HbA1c) and body weight over 8-10 months in 194 participants. The goal was to see i…

This study followed 650 adults with type 2 diabetes in Japan who were already prescribed oral semaglutide (Rybelsus) by their doctors. Researchers tracked changes in blood sugar levels and body weight over 8-10 months, along with any side effects. The goal was to see how the medi…

This study tested whether taking daily vitamin D3 and prebiotics (inulin) for six months could improve heart health markers in 190 adults with type 2 diabetes. Researchers measured blood sugar control, cholesterol, and gut bacteria changes. The goal is to find simple dietary ways…

This study tested whether a digital app combined with a 12-week very low-calorie diet (800 calories per day) could help adults with type 2 diabetes lose weight and achieve remission. One hundred participants were randomly assigned to either the digital program or standard care. T…

This completed phase 4 trial tested whether semaglutide (a GLP-1 agonist drug) can improve the health of blood vessel repair cells and fat stem cells in people with type 2 diabetes. Ten participants received either semaglutide or a placebo for 24 weeks. Researchers measured chang…

This completed study looked at three ways to help people aged 65 and older with type 2 diabetes improve their physical and metabolic health. One group did home-based circuit resistance training, another followed a plant-based Mediterranean diet, and the third took the diabetes dr…

This study is testing a portable, non-invasive breath analyzer that measures tiny particles in exhaled breath to screen for conditions like type 2 diabetes, liver disease, kidney disease, and lung disease. Researchers will enroll healthy volunteers and people with known diagnoses…

This study looked at whether two blood tests, eLIFT and FibroMeter, can accurately detect liver fibrosis (scarring) in people with type 2 diabetes. The researchers compared these blood tests to standard methods like FibroScan and liver biopsy. The goal is to find a simpler, less …

This study analyzes health records from over 2 million adults across five continents to see if GLP-1 receptor agonists (like semaglutide and liraglutide) can lower the risk of developing Alzheimer's disease. It focuses on people aged 40 and older with type 2 diabetes or obesity, …

This completed study tested a 6-month program that taught nutrition and exercise to mothers and their children (ages 7-12) in the Yaqui Valley, Mexico. The goal was to improve lifestyle habits and prevent food insecurity, malnutrition, and related health problems like heart disea…

This study tested a family-focused lifestyle program designed to help rural Hispanic and non-Hispanic adults lower their risk for heart disease and type 2 diabetes. Over 500 participants took part in a culturally tailored program that encouraged healthy eating, physical activity,…

This study tested a special diabetes prevention program for college students at high risk for type 2 diabetes, especially those facing challenges like food or financial insecurity. 80 UCLA undergraduates with prediabetes or high risk were randomly assigned to either the program o…

This study tested two local anesthesia techniques—intraseptal and periodontal ligament—in 120 adults with controlled type 2 diabetes who needed a tooth pulled. The goal was to see which method numbs better and how it affects blood pressure and heart rate. Results help dentists ch…

This study tested whether semaglutide, a diabetes medicine, improves walking ability in people with type 2 diabetes and peripheral artery disease (narrowed leg arteries). About 792 adults received weekly injections of semaglutide or a placebo for 59 weeks. The main goal was to se…

This early-stage study tested a new medicine called MK-2828 in 46 adults with type 2 diabetes. The main goal was to see if the drug is safe and well-tolerated. Researchers also measured how the drug moves through the body and its effect on a marker of inflammation (hsCRP). This i…

This study tested a new insulin dosing calculator for adults with type 2 diabetes when they are admitted to the hospital. The goal was to see if the calculator helps control blood sugar without causing dangerously low levels. Thirty-eight participants received their initial insul…

This study tested whether a special type of lighting, called a tailored lighting intervention, could help people with mild to moderate Alzheimer's disease and type 2 diabetes sleep better and improve their metabolism. Sixty-one participants living in assisted living or nursing ho…

This study tested whether a special set of exercises, called modified Otago exercises, could help people with type 2 diabetes who have nerve damage in their feet. 38 participants did these exercises for 8 weeks, and researchers measured their balance, joint position sense, blood …

This study tested how easy and convenient the DuraTouch® device is for injecting insulin. 128 people with type 1 or type 2 diabetes used the device for 12 weeks and rated their satisfaction. The goal was to see if the device improves the daily injection experience.

This study looked at whether eating 3 low-calorie meals a day is better than 5 small meals for blood sugar control and weight loss in people with type 2 diabetes who are overweight or obese. Fifty adults aged 40-70 followed one of the two meal plans for 11 weeks. Researchers meas…

This study tested whether a 12-session group therapy program for binge eating disorder could also improve blood sugar control in adults with type 2 diabetes. 34 participants received the therapy or were placed on a waitlist. Researchers measured changes in binge eating episodes a…

This completed study tested whether online mindfulness group sessions could reduce stress, anxiety, and depression in adults with type 2 diabetes. 140 people were split into two groups: one did 30-minute mindfulness exercises online, the other did not. Researchers measured change…

This study tested whether eating house cricket powder before a meal could lower blood sugar spikes in people with type 2 diabetes. Twenty adults on metformin took part, consuming cricket powder, whey protein, or a placebo mixed into soup. Researchers measured blood glucose and in…

This study tested whether mindfulness training helps people with type 2 diabetes better manage food cravings and stick to a low-carb diet. Sixty adults participated, learning skills to notice cravings without automatically eating. The goal was to improve long-term diet adherence …

This study tested whether foot-ankle exercises and walking exercises can reduce foot nerve pain, stress, and improve quality of life in people with type 2 diabetes. 375 adults with diabetes were split into three groups: foot-ankle exercises, walking exercises, or standard care. T…

This study tested whether an injection of umbilical cord stem cell secretome is safe and can improve erections in 12 men with severe erectile dysfunction that did not respond to sildenafil (Viagra). All participants had type 2 diabetes. The treatment was given as a single injecti…

This study tested whether an online mindfulness program could help adults with type 1 or type 2 diabetes lower their blood sugar. Over 300 participants with high stress and poor glucose control were randomly assigned to either an 8-week Mindfulness-Based Stress Reduction course o…

This study investigates whether type 2 diabetes changes the levels of key growth factors and inflammatory markers in Albumin Platelet-Rich Fibrin (Alb-PRF) membranes—a blood-derived material used to support wound healing and dental tissue repair. Researchers will compare Alb-PRF …

This study tested whether training healthcare providers to prescribe continuous glucose monitors (CGMs) increases their use among patients with type 2 diabetes. Researchers trained clinic staff at three community health centers serving a mostly Hispanic/Latino population. They th…

This observational study investigates whether a substance in the blood called nociceptin is linked to overactive nerves in people who have both type 2 diabetes and metabolic fatty liver disease. Researchers will compare 50 patients with both conditions to 50 healthy volunteers, m…

This completed study at Northwestern University brought together 35 patients, caregivers, and healthcare providers to discuss how to improve the identification and management of high blood sugar (hyperglycemia) and diabetes during hospital stays and when moving between care setti…

This study analyzed health records from nearly 195,000 people in Denmark, Sweden, and Norway to see if semaglutide (the drug in Ozempic and Rybelsus) is linked to a higher risk of pancreatic cancer. Researchers compared new users of semaglutide to new users of other diabetes medi…

This completed study looked at 1759 adults aged 18-55 to uncover why some people develop type 2 diabetes. Researchers measured how the body handles sugar, uses energy, and stores fat, and also collected genetic samples. The goal was to find genetic and lifestyle factors that lead…

This long-running study follows over 12,000 people from the Gila River Indian Community in Arizona to understand why type 2 diabetes develops and how it leads to complications. Participants receive regular check-ups every two years, including blood tests and physical exams. The g…

This study looks at how type 2 diabetes affects young people aged 12 to 25. Researchers want to see if giving the pancreas a 2-week rest with insulin shots can improve its ability to make insulin. Participants take metformin, follow a diet, and some also get insulin. The study al…

This completed study looked at how rising temperatures affect people with chronic conditions like heart disease, diabetes, and depression. Researchers in Germany and Italy surveyed 176 patients to see what symptoms they experienced during heat and what protective steps they took.…

This study looked at 115 adults with prediabetes to understand why different people develop the condition. Researchers tested how each person's body responds to different foods, aiming to create personalized diet plans that prevent diabetes. The goal was to find biological marker…

This study looked at whether exercising in the morning (7-11am) or afternoon (4-8pm) makes a difference for people with type 2 diabetes or prediabetes. Thirty-six adults did 10 supervised exercise sessions at a high intensity. Researchers measured changes in body weight, blood su…

This study tested whether a pop-up alert in the electronic medical record could help doctors remember to refer patients with fatty liver disease (NASH) to a liver specialist. Thirty doctors from internal medicine, family medicine, and endocrinology took part. The goal was to see …

This completed study looked at 172 people with and without HIV to understand why those with HIV have a higher risk of diabetes. Researchers examined fat tissue and immune cells to see if chronic immune activation in fat contributes to insulin resistance. The goal was to learn how…

This early-stage trial looked at how a single 50mg dose of pyroglutamate rongliflozin capsules behaves in 32 adults with mild or moderate liver damage and type 2 diabetes, compared to healthy volunteers. Researchers measured drug levels in the blood and tracked side effects to un…

This study tested whether a family history app can help doctors collect and use information about patients' family health risks. Over 600 adults aged 30-69 took part. The goal was to see if the app leads to better screening and genetic referrals for conditions like cancer, heart …

This study looked at how inherited gene variants influence the body's response to two common type 2 diabetes medications, metformin and glipizide. Over 1,000 participants took each drug and had their glucose and insulin levels measured. The goal was to understand why some people …

This completed early-phase study tested different doses of fatty acids (Intralipid) in 9 healthy volunteers to find the dose that causes mild insulin resistance. The goal was to create a reliable model for future diabetes research. Participants received low or medium doses of fat…

This completed study in Kazakhstan looked at 240 adults recently diagnosed with diabetes. Researchers measured blood sugar, insulin resistance, and immune markers to understand how different forms of diabetes develop. The goal is to help doctors diagnose and treat adult-onset dia…

This study tested a new insulin called insulin icodec in 18 children and teenagers (ages 10 to 17) with type 2 diabetes. Each participant received a single injection based on their body weight, and researchers measured how the insulin moved through their blood over time. The goal…

This completed phase 1 study tested how different levels of kidney function affect the processing of a single dose of the experimental drug NNC0519-0130. Thirty-six adults with type 2 diabetes and varying kidney function (normal to severely impaired) received one injection. Resea…

This study analyzed health records of over 200,000 adults with obesity and type 2 diabetes to see if taking GLP-1 drugs (like Ozempic) before a cancer diagnosis is linked to better survival and fewer complications after cancer. The researchers compared GLP-1 users to those on oth…

This study looked at 470 adults aged 18-75 with type 2 diabetes and metabolic syndrome to identify their Traditional Chinese Medicine (TCM) patterns. Researchers used a standard questionnaire and four TCM diagnostic methods to classify each person's syndrome. The goal was to bett…

This study compared how quickly the stomach empties a sugary drink in 30 white Europeans and 30 people of Black African or Caribbean descent. The goal was to understand why Black African/Caribbean people have a higher risk of type 2 diabetes. Researchers measured blood sugar, ins…

This completed phase 1 trial looked at whether a new experimental drug called NNC0519-0130 changes how the body processes a common birth control pill (ethinylestradiol and levonorgestrel) and how fast the stomach empties. Forty-seven healthy postmenopausal women took part. The go…

This study tested a program called DM-BOOST para Latinx, designed to help Latinx adults with type 2 diabetes better manage their condition. The program used behavioral economics and technology to improve outreach and self-management support. Twenty participants were involved to s…

This study looked at how semaglutide, a diabetes medicine, affects the kidneys in people with type 2 diabetes and chronic kidney disease. 106 participants received either semaglutide or a placebo injection once a week for about a year. Researchers used MRI scans, blood and urine …

This completed study looked at healthcare claims data from over 58,000 people to see if it could reproduce the results of the STEP-HFpEF DM trial, which tested semaglutide for heart failure with preserved ejection fraction in people with type 2 diabetes. Researchers compared new …

This study looked at how insulin use affects breathing and recovery after exercise in people with type 2 diabetes. 70 adults completed breathing tests and a 6-minute walk. The goal was to see if insulin users have different breathing strength or recovery patterns.

This completed study looked at whether information from healthcare claims (like insurance records) can be used to get similar results as a real clinical trial. Researchers compared people with type 2 diabetes and heart failure who started taking tirzepatide to those who started t…

This study tested how well the GLUCUBE system measures blood sugar in 52 adults with type 2 diabetes. Participants used the device at home and compared its accuracy to a standard finger-stick monitor. The goal was to see if the system becomes more accurate with longer use.

This study looked at whether viral infections and diabetes in pregnant women are linked to congenital heart defects in their babies. Researchers analyzed blood and stool samples from 114 women to detect viruses and immune responses. The goal was to gather knowledge for future lar…

This study looked at 67 adults with type 2 diabetes and fatty liver disease who were starting a type of diabetes medication called SGLT2 inhibitors. Researchers used ultrasound and blood tests to measure changes in liver stiffness and fat after 6 months of treatment. The goal was…

This completed Phase 4 trial at the Cleveland Clinic enrolled 69 adults with type 2 diabetes or obesity who take GLP-1 medications. Participants were randomly assigned to either continue or pause their GLP-1 drug before an upper endoscopy. The goal was to see if holding the medic…

This study looked at 202 adults with type 2 diabetes and early-stage diabetic eye disease (non-proliferative diabetic retinopathy). Researchers used non-invasive eye scans to find markers that could predict if the disease would get worse or lead to sight-threatening problems. The…

This study tested two strategies to improve how often people with type 2 diabetes are referred to and attend diabetes self-management education (DSMES) classes. Researchers gave providers alerts in the electronic health record and offered peer support to patients. The goal was to…

This completed study analyzed health records from over 158,000 people with type 2 diabetes to see if injectable semaglutide reduces major heart problems like heart attacks and strokes. Researchers used real-world data to mimic a previous clinical trial, aiming to learn when such …

This study tested a clinical decision support tool called PREVENT to help nurses prioritize which patients need homecare most urgently after leaving the hospital. Researchers studied nearly 2,000 adults with conditions like diabetes, heart failure, and lung disease to see if the …

This study looked at whether people with type 2 diabetes need to attend all sessions of a diabetes self-management education program to see benefits. 120 participants were split into groups that attended 100%, 60%, 10%, or no education. Researchers measured changes in self-care, …

This study looks at 55 adults with diabetes who are either allergic to insulin or not, to better understand and diagnose insulin allergy. Researchers will test a step-by-step diagnostic approach and study the immune system's role. The goal is to make it easier to identify the exa…