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New diabetes drug shows promise for teens in landmark trial

NCT ID NCT05260021

Completed Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a medication called tirzepatide in children and teenagers aged 10 to 17 with type 2 diabetes. Participants were already taking metformin or insulin but still had high blood sugar. The goal was to see if tirzepatide could safely lower blood sugar levels better than a placebo over about 60 weeks.

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Conditions

The condition(s) this trial relates to.

diabetes mellitus endocrine system disorder glucose metabolism disease metabolic disease type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETES MELLITUS DIABETES MELLITUS, TYPE 2 ENDOCRINE SYSTEM DISEASES GLUCOSE METABOLISM DISORDERS METABOLIC DISEASE T2D T2DM (TYPE 2 DIABETES MELLITUS) TYPE2 DIABETES

Contacts and locations

Locations

  • AA Medical Research Center

    Flint, Michigan, 48504, United States

  • All India Institute of Medical Sciences

    New Delhi, National Capital Territory of Delhi, 110029, India

  • Arké SMO S.A de C.V

    Veracruz, 91910, Mexico

  • Assistance Publique - Hopitaux de Paris (AP-HP) - Hopital Robert Debre - Centre Hospitalo Universitaire (C -T

    Paris, 75019, France

  • Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Trento

    Verona, Veneto, 37126, Italy

  • Azienda Ospedaliera Universitaria dell'Università "Luigi Vanvitelli" Piazza Luigi Miraglia, 2 Napoli Campa -T

    Naples, Campania, 80138, Italy

  • Bhakti Vedanta Hospital and Research Institute

    Thane, Maharashtra, 401107, India

  • CEDOES

    Vitória, Espírito Santo, 29055450, Brazil

  • CEPIC - Centro Paulista de Investigação Clínica

    São Paulo, 04266-010, Brazil

  • CPQuali Pesquisa Clínica

    São Paulo, 01228-000, Brazil

  • Center Of Excellence in Diabetes and Endocrinology

    Sacramento, California, 95821, United States

  • Centre Hospitalier Universitaire d'Angers

    Angers, Maine-et-Loire, 49933, France

  • Centre for Children's Health Research

    Brisbane, Queensland, 4101, Australia

  • Centro de Diabetes Curitiba

    Curitiba, Paraná, 80810-040, Brazil

  • Centro de Pesquisa Sao Lucas

    Campinas, São Paulo, 13034-685, Brazil

  • Children's Hospital Colorado

    Aurora, Colorado, 80045, United States

  • Children's Hospital Los Angeles

    Los Angeles, California, 90027, United States

  • Children's Hospital of Philadelphia (CHOP)

    Philadelphia, Pennsylvania, 19104, United States

  • Clínica Cemain

    Tampico, Tamaulipas, 89170, Mexico

  • Consano Clinical Research, LLC

    Shavano Park, Texas, 78231, United States

  • Consultorio Médico de Endocrinología y Pediatría

    Puebla City, 72190, Mexico

  • Gujarat Endocrin Pvt Ltd

    Ahmedabad, Gujarat, 380052, India

  • Hull Royal Infirmary

    Hull, Kingston Upon Hull, HU3 2JZ, United Kingdom

  • Indiana University Health University Hospital

    Indianapolis, Indiana, 46202, United States

  • Instituto Méderi de Pesquisa e Saúde

    Passo Fundo, Rio Grande do Sul, 99010-120, Brazil

  • Instituto da Crianca com Diabetes

    Porto Alegre, Rio Grande do Sul, 91350-250, Brazil

  • Instituto da Crianca do Hospital das Clinicas da FMUSP

    São Paulo, São Paulo, 05403-000, Brazil

  • Instituto de Pesquisa Clinica

    São Paulo, São Paulo, 01223-001, Brazil

  • Instituto de Pesquisa clinica de Campinas

    Campinas, São Paulo, 13060-080, Brazil

  • Investigacion En Salud Y Metabolismo Sc

    Chihuahua City, 31217, Mexico

  • Kovai Diabetes Speciality Center and Hospital

    Coimbatore, Tamil Nadu, 641009, India

  • Leicester General Hospital

    Leicester, Leicestershire, LE5 4PW, United Kingdom

  • Leicester Royal Infirmary

    Leicester, England, LE1 5WW, United Kingdom

  • M S Ramaiah Medical College and Hospitals

    Bangalore, Karnataka, 560054, India

  • Nemours Children's Health - Delaware

    Wilmington, Delaware, 19803, United States

  • Ospedale Pediatrico Salesi

    Ancona, 60123, Italy

  • Perth Children's Hospital

    Perth, Western Australia, 6009, Australia

  • Postgraduate Institute of Medical Education & Research

    Chandigarh, 160012, India

  • Qualmedica Research, LLC

    Evansville, Indiana, 47715, United States

  • Rady Children's Hospital

    San Diego, California, 92123, United States

  • Rambam Health Care Campus

    Haifa, Northern District, 3109601, Israel

  • Ruschel Medicina e Pesquisa Clínica

    Rio de Janeiro, 22270-060, Brazil

  • SUNY Upstate Medical University

    Syracuse, New York, 13210, United States

  • Shaare Zedek Medical Center

    Jerusalem, Jerusalem, 9013102, Israel

  • Sheba Medical Center

    Ramat Gan, Central District, 5262100, Israel

  • Soroka Medical Center

    Beersheba, Southern District, 8410101, Israel

  • The Children's Hospital at Westmead

    Westmead, New South Wales, 2145, Australia

  • Touro University California

    Vallejo, California, 94592, United States

  • Unidad Médica para la Salud Integral

    San Nicolás de los Garza, Nuevo León, 66465, Mexico

  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States

  • Yitzhak Shamir Medical Center

    Be’er Ya‘aqov, Central District, 70300, Israel

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