Could a daily pill help teens control type 2 diabetes?

NCT ID NCT04596631

Completed Disease control Sponsor: Novo Nordisk A/S Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a daily pill called oral semaglutide helps children and teenagers (ages 10 to under 18) with type 2 diabetes control their blood sugar better than a placebo. All participants also took standard diabetes medicines like metformin or insulin. The trial lasted about 66 weeks and involved 132 participants. The main goal was to see if semaglutide lowered HbA1c (a measure of blood sugar control) more than the placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: oral semaglutide
What this could lead to: If it works, this could provide a new daily pill option to help children and teenagers better manage their type 2 diabetes.
What could go wrong: This is a relatively small trial in a specific age group, and the drug may not work better than placebo or could cause side effects. Long-term benefits and risks are still unknown.

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Conditions

The condition(s) this trial relates to.

type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETES MELLITUS, TYPE 2

Contacts and locations

Locations

"AHEPA" University General Hospital of Thessaloniki

Thessaloniki, 54636, Greece
"Verum clinic" LLC

Kyiv, 03039, Ukraine
All India Institute of Medical Sciences

New Dehli, New Delhi, 110029, India
Athens Paediatric Center

Athens, 15125, Greece
Barry J. Reiner, MD LLC

Baltimore, Maryland, 21229, United States
Birmingham Children's Hospital

Birmingham, B4 6NH, United Kingdom
CHU - UCL Namur - Site Sainte Elisabeth_Namur_1

Namur, 5000, Belgium
CNPE "City Clinical Hospital #9 Dnipro City Council"

Dnipro, 49023, Ukraine
Centro Hospitalar de Vila Nova de Gaia

Vila Nova de Gaia, 4400-129, Portugal
Chang Gung Memorial Hospital Linkou-Dept of Pediatrics

Taoyuan, 333, Taiwan
Children's Healthcare Atlanta

Atlanta, Georgia, 30329, United States
Children's Hospital Los Angeles - Endocrinology

Los Angeles, California, 90027, United States
Chronic Care Center

Hazmiyeh, 21211, Lebanon
City Clinical Hospital #9 (Dnipro) - Endocrinology department

Dnipro, 49023, Ukraine
Cliniques Universitaires Saint-Luc - Serv. Pédiatrie

Brussels, 1200, Belgium
Columbus Research Foundation

Columbus, Georgia, 31904, United States
Consultorio de Endocrinología y Pediatría

Puebla City, 72190, Mexico
De Kinderkliniek

Almere Stad, 1315 RC, Netherlands
Diabet Center SRL

Brasov, 500260, Romania
Dr P V Rao - Diabetes Research Centre

Hyderabad, Telangana, 50082, India
EUROMEDICA Gen Clinic The/ki, Endocrin,Metabolism,Diabetes

Thessaloniki, 54645, Greece
Emergency County Hospital Constanta

Constanța, 900591, Romania
Endolife Specialty Hospitals

Guntur, Andhra Pradesh, 522001, India
Eternal Heart Care Centre

Jaipur, Rajasthan, 302017, India
Excel Endocrine Centre

Kolhāpur, Maharashtra, 416008, India
Fakultní Nemocnice Ostrava

Ostrava-Poruba, 708 00, Czechia
GFHI Omsk Region "Regional Children's Clinical Hospital"

Omsk, 644001, Russia
General Hospital of Lamia

Lamia, 35100, Greece
General Hospital of Lamia

Lamia, GR35100, Greece
Gosford Hospital

Gosford, New South Wales, 2250, Australia
Henry Dunant Hospital Center,2nd Internal Medicine Clinic

Athens, 11526, Greece
Henry Dunant Hospital Center,2nd Internal Medicine Clinic

Athens, GR-11526, Greece
Hospital Putrajaya

Putrajaya, 62250, Malaysia
Hospital da Luz Lisboa, S.A.

Lisbon, 1500-650, Portugal
Hôpital d'Enfants

Rabat, 10000, Morocco
Iatriko Athinon (Athens Medical Canter)

Athens, 15125, Greece
Indiana Uni School of Med-Ped

Indianapolis, Indiana, 46202, United States
Jeroen Bosch Zkh

's-Hertogenbosch, 5223 GZ, Netherlands
Jothydev's Diabetes & Research Center

Thriruvananthapuram, 695 032, India
Kharkiv Regional Children's Clinical Hospital - Endocrinological department

Kharkiv, 61093, Ukraine
Komisarenko Institute of Endocrinology and Metabolism of NAMSU - Department of paediatric endocrine pathology

Kyiv, 04114, Ukraine
Liggins Institute

Grafton, 1023, New Zealand
Masarykova nemocnice v Usti nad Labem, o.z. - Detska klinika

Ústí nad Labem, 40011, Czechia
Monash Children's Hospital

Clayton, Victoria, 3168, Australia
Monument Health Clinical Rsrch

Rapid City, South Dakota, 57701, United States
Murdoch Children's Research Institute

Parkville, Victoria, 3052, Australia
NE Clin Res of San Antonio

San Antonio, Texas, 78233, United States
NSMU paediatric clinic

Novosibirsk, 630048, Russia
Nemours Children's Health

Pensacola, Florida, 32514, United States
Nemours Chld Clnc Jacksonville

Jacksonville, Florida, 32207, United States
P D Hinduja National Hospital and Medical Research Centre

Mumbai, Maharashtra, 400016, India
PHI University Clinic for Children's Diseases-Skopje

Skopje, 1000, North Macedonia
Pediatric Endo UVHS

Charlottesville, Virginia, 22908, United States
Pennington Biomed Res Ctr

Baton Rouge, Louisiana, 70808-4124, United States
Pentelis Children's Hospital - Pediatric Clinic

Penteli, Athens, 15236, Greece
Perth Children's Hospital

Nedlands, Western Australia, 6009, Australia
Ponce Med School Found Inc

Ponce, 00716, Puerto Rico
RMAPE

Moscow, 125373, Russia
Rambam MC - Department of Pediatrics A

Haifa, 31096, Israel
Ramdev Rao Hospital

Hyderabad, Telangana, 500072, India
Republic Children's Hospital of Ministry of Health of Udmurt

Izhevsk, 426009, Russia
SAHI Sverdlovsk Reg "Regional Children's Clinical Hospital"

Yekaterinburg, 620149, Russia
SPSBHI City Children out-patient clinic #44

Saint Petersburg, 191144, Russia
SSKM

Kolkata, West Bengal, 700020, India
Siberian State Medical University

Tomsk, 634050, Russia
Soroka MC - Pediatric Endocrinology

Beersheba, 84101, Israel
Spitalul Clinic de Urgenta pentru Copii "M.S.Curie"

Bucharest, 041451, Romania
Spitalul Judetean de Urgenta Targoviste

Targoviste, Dâmbovița County, 130083, Romania
Taipei Mackay Memorial Hospital

Taipei, 104, Taiwan
Texas Tech University HSC

Amarillo, Texas, 79106, United States
U.G.H. "Attikon", Pediatric Endocrinology Outpatient Clinic

Athens, 12462, Greece
UAB Ped Endo Children's Hosp

Birmingham, Alabama, 35233, United States
UBMD Peds-Div of Endo/Diabetes

Buffalo, New York, 14203, United States
UPMC Child Hosp-Pittsburgh

Pittsburgh, Pennsylvania, 15224, United States
UZ Brussel

Brussels, 1090, Belgium
Ukrainian scientific and practical center of endocrine surgery of MOH - department of paediatric endocrinology

Kiev, 01021, Ukraine
Unidade Local De Saúde De Santa Maria E.P.E.

Lisbon, 1649-035, Portugal
Univ Gen Hospital Larisa

Larissa, 41110, Greece
Univ Gen Hospital Larisa, Endocrinology & Metabolic Disease

Larissa, GR-41110, Greece
Univ Of Texas Hlth Science Cntr

San Antonio, Texas, 78207, United States
University General Hospital of Ioannina, Endocrinology

Ioannina, 45500, Greece
University Hospital of Athens ATTIKON

Athens, Attica, 12462, Greece
University Hospital of Athens ATTIKON

Haidari-Athens, Attica, GR-12462, Greece
University Malaya Medical Centre

Kuala Lumpur, Kuala Lumpur, 59100, Malaysia
University Malaya Medical Centre

Lembah Pantai, Kuala Lumpur, 59100, Malaysia
University Malaya Medical Centre

Kuala Lumpur, 59100, Malaysia
University Of Louisville Research Foundation

Louisville, Kentucky, 40202, United States
University of Mississippi Medical Center

Jackson, Mississippi, 39216, United States
University of South Florida Diabetes Center

Tampa, Florida, 33612, United States
Universitätsklinik für Kinder und Jugendheilkunde Haus E

Salzburg, 5020, Austria
Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States
Vinnytsia Regional Clinical Endocrinological Centre - Therapeutic department #2

Vinnytsia, 21010, Ukraine
Virginia Commonwealth Univ

Richmond, Virginia, 23298, United States
Virginia Commonwealth University_Richmond

Richmond, Virginia, 23298, United States
Westmead Children's Hospital- The Clinical Research Centre

Westmead, New South Wales, 2145, Australia
Women's & Children's Hospital

North Adelaide, South Australia, 5006, Australia
Yale School Of Medicine

New Haven, Connecticut, 06520, United States

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