Higher-Dose semaglutide shows promise for weight loss in diabetes patients
NCT ID NCT05649137
First seen Nov 01, 2025 · Last updated May 16, 2026 · Updated 29 times
Summary
This study tested a high dose (7.2 mg) of semaglutide, a once-weekly injection, in 512 adults with obesity and type 2 diabetes. The goal was to see how much weight participants lost and how well their blood sugar was controlled over 72 weeks, compared to a lower dose or a placebo. All participants also received counseling on healthy eating and physical activity. The study is complete and results are available.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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AMC Community Endocrinology
Albany, New York, 12203, United States
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APDP - Associação Protectora dos Diabéticos de Portugal
Lisbon, 1250-230, Portugal
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ARS- Deland CRU
DeLand, Florida, 32720, United States
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Amarillo Med Spec LLP
Amarillo, Texas, 79106, United States
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Bajcsy-Zsilinszky Kórház
Budapest, 1106, Hungary
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Belinus Bt.
Debrecen, Hajdú-Bihar, 4025, Hungary
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Borbánya Praxis E.Ü. Kft.
Nyíregyháza, Szabolcs-Szatmar Varmegye, 4405, Hungary
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Centrum Medyczne Pratia Gdynia
Gdynia, Pomeranian Voivodeship, 81-338, Poland
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Chambliss Clinical Trials, LLC
Montgomery, Alabama, 36106, United States
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ClinDiab Egészségügyi Szolgáltató és Kereskedelmi Kft.
Budapest, 1089, Hungary
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DCC VII - Sofia EOOD, Endocrinology
Sofia, 1233, Bulgaria
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DCOL Ctr for Clin Res
Longview, Texas, 75605, United States
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DIABETOL, s.r.o.
Prešov, 080 01, Slovakia
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DIADA s.r.o.
Bardejov, 08501, Slovakia
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DIADA, s.r.o.
Bardejov, 08501, Slovakia
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Deepak Lakha
Johannesburg, Gauteng, 1820, South Africa
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Diab - Int, s.r.o.
Bytča, 014 01, Slovakia
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Diablo Clinical Research, Inc.
Walnut Creek, California, 94598, United States
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Dr N.K. Gounden Medical Centre
Durban, KwaZulu-Natal, 4093, South Africa
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Dr T Padayachee
eMkhomazi, KwaZulu-Natal, 4170, South Africa
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ENDOMED, s.r.o.
Košice, 04013, Slovakia
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Elligo Clin Res Centre
Austin, Texas, 78704, United States
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Fejér Megyei Szent György Oktatókórház
Székesfehérvár, 8000, Hungary
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Florida Inst For Clin Res LLC
Orlando, Florida, 32825, United States
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G.A. Research Associates Ltd.
Moncton, New Brunswick, E1G 1A7, Canada
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Hemant Makan
Johannesburg, Gauteng, 1827, South Africa
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Hope Clin Res & Wellness
Conyers, Georgia, 30094, United States
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Hospital da Luz Arrabida, S.A.
Vila Nova de Gaia, 4400-346, Portugal
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Hospital da Luz Lisboa, S.A.
Lisbon, 1500-650, Portugal
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IPSOMC - Dr. Georgi Marinov
Burgas, 8000, Bulgaria
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Jacksonville Ctr for Clin Res
Jacksonville, Florida, 32216, United States
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John Muir Physicians Network
Concord, California, 94520, United States
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Kresmed Sp. z o. o.
Bialystok, Podlaskie Voivodeship, 15-481, Poland
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Lausmed Kft.
Baja, Bács-Kiskun county, 6500, Hungary
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Lenmed Shifa Private Hospital
Durban, KwaZulu-Natal, 4901, South Africa
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MED-DIA CENTRUM s.r.o.
Považská Bystrica, 01701, Slovakia
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MED-TIMA Kft.
Budapest, 1132, Hungary
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MHAT - Blagoevgrad AD, Department of Internal Diseases
Blagoevgrad, 2700, Bulgaria
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MHAT Hadzhi Dimitar OOD
Sliven, 8800, Bulgaria
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MHAT Sveta Karidad EAD
Plovdiv, 4004, Bulgaria
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MHAT Sveti Panteleimon - Yambol AD
Yambol, 8600, Bulgaria
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Maxwell Centre
Durban, KwaZulu-Natal, 4001, South Africa
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Med. Cent. Diabet. Endo. Metabol. DIAB-ENDO-MET
Krakow, Lesser Poland Voivodeship, 31-261, Poland
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Medi-Clinic Bloemfontein
Bloemfontein, Free State, 9301, South Africa
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Medical Center Viva Feniks OOD
Dobrich, 9300, Bulgaria
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Milestone Research
London, Ontario, N5W 6A2, Canada
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NBR Polska Tomasz Klodawski
Warsaw, 00-710, Poland
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NZOZ "CenterMed Lublin" Sp. z o.o.
Lublin, Lublin Voivodeship, 20-044, Poland
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NZOZ Przychodnia Specjalistyczna Medica
Lublin, Lubelski, 20-538, Poland
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National Clin Res Inc.
Richmond, Virginia, 23294, United States
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New West Physicians PC
Golden, Colorado, 80401, United States
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Nova Scotia Hlth Halifax
Halifax, Nova Scotia, B3H 1V7, Canada
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Ocean West Research Clinic
Surrey, British Columbia, V3Z 2N6, Canada
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Oviedo Medical Research, LLC
Oviedo, Florida, 32765, United States
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PANSTWOWY INSTYTUT MEDYCZNY MSWiA
Warsaw, 02-507, Poland
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PharmQuest Life Sciences LLC
Greensboro, North Carolina, 27408, United States
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Phoenix Pharma
Port Elizabeth, Eastern Cape, 6001, South Africa
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PlanIt Research, PLLC
Houston, Texas, 77079, United States
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Precise Clinical Solutions (Pty) Ltd
Durban, KwaZulu-Natal, 4092, South Africa
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Premier Clinical Trial Research Network (PCTRN)
Hamilton, Ontario, L8L 5G4, Canada
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Selma Medical Associates
Winchester, Virginia, 22601-3834, United States
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Soweto Clinical Trial Centre
Johannesburg, Gauteng, 1818, South Africa
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Sugar Lakes Family Practice PA
Sugar Land, Texas, 77479, United States
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ULS De Matosinhos E.P.E.- Hospital Pedro Hispano
Senhora Da Hora, Matosinhos, Matosinhos, 4464-513, Portugal
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ULS De São João, E.P.E. - Hospital de São João
Porto, 4200-319, Portugal
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UMHAT Prof. Dr. Stoyan Kirkovich AD
Stara Zagora, 6003, Bulgaria
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UMHAT Pulmed OOD - Pazardzhik, Department of Internal Diseases
Pazardzhik, 4400, Bulgaria
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UT Southwestern Medical Center - Lingvay
Dallas, Texas, 75390, United States
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Unidade Local De Saúde De Lisboa Ocidental E.P.E. - Hospital Egas Moniz
Lisbon, 1349-019, Portugal
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Univ of Alabama Birmingham
Birmingham, Alabama, 35222, United States
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University of North Carolina
Chapel Hill, North Carolina, 27514, United States
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Uniwersyteckie Centrum Kliniczne SUM w Katowicach
Katowice, 40-752, Poland
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Velocity Clin Res, Dallas
Dallas, Texas, 75230, United States
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Velocity Clinical Research Westlake
Los Angeles, California, 90057, United States
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Wharton Medical Clinic Clinical Trials (Hamilton)
Hamilton, Ontario, L8L 5G8, Canada
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Wits Bara Clinical Trial Site
Johannesburg, Gauteng, 2013, South Africa
Conditions
Explore the condition pages connected to this study.