Electric pulses to the gut: a new hope for diabetes?

NCT ID NCT05014204

Completed Disease control Sponsor: Endogenex, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early study tested a device that uses mild electric pulses to regenerate the lining of the upper small intestine in 20 adults with type 2 diabetes. The goal was to see if the procedure is safe and could help lower blood sugar. Participants were on 2-3 diabetes pills and had the procedure done through an endoscope, without surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Endogenex device (uses pulsed electric fields to regenerate the duodenal lining)
What this could lead to: If it works, this could offer a non-surgical, one-time procedure to help control blood sugar in type 2 diabetes, potentially reducing the need for multiple medications.
What could go wrong: This is a very small, early feasibility study with only 20 participants and no control group. The device may not improve blood sugar meaningfully, and there are risks from the endoscopic procedure itself.

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Conditions

The condition(s) this trial relates to.

diabetes mellitus endocrine system disorder glucose metabolism disease metabolic disease type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETES DIABETES MELLITUS DIABETES MELLITUS, TYPE 2 DIABETES TYPE 2 ENDOCRINE SYSTEM DISEASES GLUCOSE METABOLISM DISORDERS METABOLIC DISEASE

Contacts and locations

Locations

Cuyuna Regional Medical Center

Crosby, Minnesota, 56441, United States
Mayo Clinic

Rochester, Minnesota, 55905, United States
University of Southern California

Los Angeles, California, 90033, United States

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