Electric pulses to the gut: a new hope for diabetes?
NCT ID NCT05014204
First seen Dec 24, 2025 · Last updated Jun 22, 2026 · Updated 32 times
Summary
This early study tested a device that uses mild electric pulses to regenerate the lining of the upper small intestine in 20 adults with type 2 diabetes. The goal was to see if the procedure is safe and could help lower blood sugar. Participants were on 2-3 diabetes pills and had the procedure done through an endoscope, without surgery.
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the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Cuyuna Regional Medical Center
Crosby, Minnesota, 56441, United States
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Mayo Clinic
Rochester, Minnesota, 55905, United States
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University of Southern California
Los Angeles, California, 90033, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Endogenex device (uses pulsed electric fields to regenerate the duodenal lining)
What this could lead to
If it works, this could offer a non-surgical, one-time procedure to help control blood sugar in type 2 diabetes, potentially reducing the need for multiple medications.
What could go wrong
This is a very small, early feasibility study with only 20 participants and no control group. The device may not improve blood sugar meaningfully, and there are risks from the endoscopic procedure itself.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.