Could a Low-Calorie diet ease heart failure symptoms?
NCT ID NCT05887271
First seen Jun 27, 2026 · Last updated Jul 23, 2026 · Updated 2 times
Summary
This study tests whether a 12-week low-calorie meal replacement diet can improve heart function and exercise ability in people with heart failure with preserved ejection fraction (HFpEF) who are also obese. 63 adults will be randomly assigned to either the diet or standard care. The main goal is to see if they can walk farther in a 6-minute walk test after 12 weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- low-calorie meal replacement diet (850 kcal/day)
- What this could lead to
- If successful, this diet could become a simple, non-drug way to improve heart function and daily activity in people with heart failure and obesity.
- What could go wrong
- This is a small early-phase trial with only 63 participants, so results may not apply to everyone. The diet is very low in calories and may be hard to follow long-term.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of Leicester, Glenfield Hospital, Groby Road
Leicester, Leicestershire, LE3 9QP, United Kingdom
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University of Manchester, Wythenshawe Hospital, Southmoor Road
Manchester, M23 9LT, United Kingdom
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University of Oxford, John Radcliffe Hospital, Headley Way
Oxford, OX3 9DU, United Kingdom
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