Could a Low-Calorie diet ease heart failure symptoms?
NCT ID NCT05887271
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a 12-week low-calorie meal replacement diet can improve heart function and exercise ability in people with heart failure with preserved ejection fraction (HFpEF) who are also obese. 63 adults will be randomly assigned to either the diet or standard care. The main goal is to see if they can walk farther in a 6-minute walk test after 12 weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
low-calorie meal replacement diet (850 kcal/day)
What this could lead to
If successful, this diet could become a simple, non-drug way to improve heart function and daily activity in people with heart failure and obesity.
What could go wrong
This is a small early-phase trial with only 63 participants, so results may not apply to everyone. The diet is very low in calories and may be hard to follow long-term.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University of Leicester, Glenfield Hospital, Groby Road
RECRUITINGLeicester, Leicestershire, LE3 9QP, United Kingdom
Contact Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Manchester, Wythenshawe Hospital, Southmoor Road
RECRUITINGManchester, M23 9LT, United Kingdom
Contact Email: •••••@•••••
Contact
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University of Oxford, John Radcliffe Hospital, Headley Way
RECRUITINGOxford, OX3 9DU, United Kingdom
Contact Email: •••••@•••••
Contact