Diabetes duo: new combo shot shows promise for blood sugar

NCT ID NCT04982575

Completed Disease control Sponsor: Novo Nordisk A/S Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether combining two injectable drugs, cagrilintide and semaglutide, works better than either drug alone for lowering blood sugar in people with type 2 diabetes. 92 adults with type 2 diabetes and a BMI of 27 or higher took part. Participants received weekly injections of either the combo or one drug plus a placebo for 32 weeks. The main goal was to see how much HbA1c (a blood sugar measure) dropped from start to week 32.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: cagrilintide and semaglutide (injectable drugs)
What this could lead to: If it works, this combination could offer better blood sugar control for people with type 2 diabetes than either drug alone.
What could go wrong: This is a small, early-phase trial (Phase 2) with only 92 participants. Results may not apply to everyone, and side effects or lack of added benefit are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETES MELLITUS, TYPE 2

Contacts and locations

Locations

Accellacare

Wilmington, North Carolina, 28401, United States
Capital Clin Res Ctr,LLC

Olympia, Washington, 98502, United States
Clinical Trial Res Assoc,Inc

Plantation, Florida, 33324, United States
DCOL Ctr for Clin Res

Longview, Texas, 75605, United States
East West Med Res Inst

Honolulu, Hawaii, 96814, United States
Ellipsis Group

Alpharetta, Georgia, 30022, United States
Encompass Clinical Research_Spring Valley

Spring Valley, California, 91978, United States
FPA Clinical Research

Kissimmee, Florida, 34741, United States
Florida Inst For Clin Res

Orlando, Florida, 32825, United States
Holston Medical Group

Kingsport, Tennessee, 37660, United States
Lillestol Research LLC

Fargo, North Dakota, 58104, United States
MD Medical Research

Oxon Hill, Maryland, 20745, United States
Macoupin Research Group

Gillespie, Illinois, 62033, United States
New West Physicians,Inc.

Golden, Colorado, 80401, United States
Pacific Clinical Studies

Los Alamitos, California, 90720, United States
PharmQuest Life Sciences LLC

Greensboro, North Carolina, 27408, United States
Plains Clinical Research Center, LLC_Fargo

Fargo, North Dakota, 58104, United States
PlanIt Research, PLLC

Houston, Texas, 77079, United States
Selma Medical Associates

Winchester, Virginia, 22601-3834, United States
Uni of Alabama at Birmingham

Birmingham, Alabama, 35233, United States
Valley Research

Fresno, California, 93720, United States
Velocity Clin Res Los Angeles

Los Angeles, California, 90017, United States
Velocity Clinical Res-Dallas

Dallas, Texas, 75230, United States

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