Nerve-Cutting surgery may boost diabetes remission after gastric bypass

NCT ID NCT07278115

Recruiting now Disease control Sponsor: University Research Institute for the Study of Genetic & Malignant Disorders in Childhood Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares standard gastric bypass surgery to bypass plus a nerve-cutting procedure (truncal vagotomy) in 40 adults with obesity and type 2 diabetes. The goal is to see if the added nerve cut helps more people achieve diabetes remission without medication for at least a year. Participants will be followed for 12 months after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Roux-en-Y gastric bypass with or without truncal vagotomy
What this could lead to: If it works, this could point toward a more effective surgical approach for lasting diabetes remission in people with obesity.
What could go wrong: This is a small, early-phase trial with only 40 participants. The added vagotomy may not improve outcomes and could increase surgical risks or side effects.

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Conditions

The condition(s) this trial relates to.

hyperglycemia Insulin Resistance Obesity type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETES MELLITUS, TYPE 2

Contacts and locations

Locations

Diabetes Surgery
RECRUITING

Athens, Attica, 11527, Greece
Diabetes Surgery
NOT_YET_RECRUITING

Athens, Attica, 11527, Greece

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