New hope for kids with kidney disease: finerenone safety trial underway

NCT ID NCT05457283

Recruiting now Disease control Sponsor: Bayer Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests the long-term safety of finerenone, a drug that helps control a key system involved in kidney damage, in children aged 1 to 18 with chronic kidney disease and proteinuria. All 100 participants will take finerenone alongside their usual ACE inhibitor or ARB medication for up to 18 months. Researchers will monitor side effects, blood pressure, potassium levels, and kidney function to see if the combination is safe and may help protect the kidneys.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Finerenone (Kerendia)

What this could lead to

If successful, this could show that adding finerenone to standard treatment is a safe way to help control kidney disease in children.

What could go wrong

This is an extension study focused on safety, not a cure. It is still early in children, and results may not show clear benefit or may reveal side effects like high potassium levels.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

chronic kidney disease chronic renal failure syndrome proteinuria

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHILDREN CHRONIC KIDNEY DISEASE PROTEINURIA

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

A.O.U. Città della Salute e della Scienza di Torino_Regina Margherita - Nefrologia Pediatrica
RECRUITING

Torino, 10126, Italy
Aarhus Universitetshospital - Børn og Unge
COMPLETED

Aarhus N, Central Jutland, 8200, Denmark
Alberta Children's Hospital | Nephrology Clinic
NOT_YET_RECRUITING

Calgary, Alberta, T3B 6A8, Canada
All India Institute of Medical Sciences (AIIMS) - New Delhi
ACTIVE_NOT_RECRUITING

Delhi, National Capital Territory of Delhi, 110029, India
Azienda Ospedaliera Universitaria Meyer IRCCS - Nefrologia e Dialisi
RECRUITING

Florence, 50139, Italy
Azienda Ospedaliero-Universitaria Di Bologna IRCCS_Policlinico Sant'Orsola - Pediatria
RECRUITING

Bologna, Emilia-Romagna, 40138, Italy
Baskent Universitesi Tip Fakultesi Hastanesi
RECRUITING

Ankara, 6490, Turkey (Türkiye)
Birmingham Children's Hospital
NOT_YET_RECRUITING

Birmingham, West Midlands, B4 6NH, United Kingdom
Boston Children's Hospital - Main Campus - Nephrology
WITHDRAWN

Boston, Massachusetts, 02115, United States
CHC Montlégia - Pediatrics
NOT_YET_RECRUITING

Liège, 4000, Belgium
CHU Montpellier - Hopital Arnaud de Villeneuve
RECRUITING

Montpellier, Occitanie, 34059, France
CHU Strasbourg - Hopital Hautepierre
NOT_YET_RECRUITING

Strasbourg, Grand Est, 67200, France
CHU bordeaux - Hopital Pellegrin
NOT_YET_RECRUITING

Bordeaux, New Aquitaine, 33076, France
CHU de Lyon - Hopital Femme Mère Enfant
RECRUITING

Bron, Auvergne-Rhône-Alpes, 69677, France
CU Saint-Luc/UZ St-Luc
NOT_YET_RECRUITING

Brussels, Brussels Capital, 1200, Belgium
Cedars-Sinai Samuel Oschin Cancer Center
WITHDRAWN

Los Angeles, California, 90048, United States
Centre Hospitalier Universitaire Vaudois (CHUV)
RECRUITING

Lausanne, Canton of Vaud, 1012, Switzerland
Centre hospitalier universitaire Sainte-Justine | Cardiology
RECRUITING

Montreal, Quebec, H3T 1C5, Canada
Centro de Rehabilitacion Cardiovascular | San Luis, Argentina
RECRUITING

San Luis, D5700CGR, Argentina
Chang Gung Memorial Hospital (CGMH) - Kaohsiung Branch
NOT_YET_RECRUITING

Guishan, Taoyuan, 83301, Taiwan
Chang Gung Memorial Hospital at Linkou
RECRUITING

Taipei, 10507, Taiwan
Charité / Pädiatrie
ACTIVE_NOT_RECRUITING

Berlin, 13353, Germany
Children's Hospital of Athens Agia Sofia - Pediatric Nephrology Department
RECRUITING

Athens, 11527, Greece
Children's Hospital of Athens P&A Kyriakou - Pediatric Nephrology Department
RECRUITING

Athens, 11526, Greece
Children's Hospital of Philadelphia - Nephrology
NOT_YET_RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Children's Mercy Hospital Kansas City - Nephrology
NOT_YET_RECRUITING

Kansas City, Missouri, 64108, United States
Children's National Hospital - Nephrology
NOT_YET_RECRUITING

Washington D.C., District of Columbia, 20010, United States
Cincinnati Children's Hospital Medical Center | Division of Nephrology and Hypertension
NOT_YET_RECRUITING

Cincinnati, Ohio, 45229, United States
Clalit Health Services Schneider Children's Medical Center
COMPLETED

Petah Tikva, 4920235, Israel
Clalit Health | Soroka Medical Center- Nephrology Department
RECRUITING

Beersheba, 8410101, Israel
Cleveland Clinic | Pediatric Nephrology
RECRUITING

Cleveland, Ohio, 14013, United States
Clinica de Nefrologia, Urologia y Enfermedades Cardiovascualares | Santa Fe, Argentina
NOT_YET_RECRUITING

Santa Fe, Santa Fe Province, S3000, Argentina
Cukurova Univ. Tip. Fak. Balcali Hastanesi
NOT_YET_RECRUITING

Adana, 01790, Turkey (Türkiye)
Dana-Dwek Children's Hospital
RECRUITING

Tel Aviv, 6423906, Israel
Debreceni Egyetem Klinikai Kozpont
COMPLETED

Debrecen, Hajdú-Bihar, 4032, Hungary
Eccles Primary Children's Outpatient Services - Nephrology
RECRUITING

Salt Lake City, Utah, 84113, United States
Emory University Hospital/Children's Healthcare of Atlanta - Nephrology
WITHDRAWN

Atlanta, Georgia, 30322, United States
Fakultní nemocnice Motol a Homolka, Pracovište MOTOL
RECRUITING

Prague, Prague, 150 06, Czechia
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Nefrologia e Dialisi Pediatrica, Trapianti di Rene
RECRUITING

Milan, Lombardy, 20122, Italy
Gazi Universitesi Tip Fakultesi
NOT_YET_RECRUITING

Ankara, 6560, Turkey (Türkiye)
Great Ormond Street Hospital for Children NHS Foundation Trust | Great Ormond Street Hospital - Clinical Research Facility
ACTIVE_NOT_RECRUITING

London, Greater London, WC1N 3JH, United Kingdom
HUS-Yhtymä, Helsingin yliopistollinen sairaala (HUS) - Uusi lastensairaala, nefrologia
RECRUITING

Helsinki, Uusimaa, 00290, Finland
Hacettepe Universitesi Tip Fakultesi
NOT_YET_RECRUITING

Ankara, 06230, Turkey (Türkiye)
Health Corporation of Galilee Medical Center
COMPLETED

Nahariya, 2210001, Israel
Hopital Robert Debre
RECRUITING

Paris, Île-de-France Region, 75019, France
Hopital des Enfants HUG
RECRUITING

Geneva, 1211, Switzerland
Hosp Clínicas Facult. Med. de Ribeirão Preto / USP
NOT_YET_RECRUITING

Ribeirão Preto, São Paulo, 14051-140, Brazil
Hospital General de Ninos Pedro de Elizalde | Nephrology Department
RECRUITING

Buenos Aires, C1270AAN, Argentina
Hospital General de Ninos Ricardo Gutierrez | Pediatric Nephrology Department
RECRUITING

Buenos Aires, C1425EFD, Argentina
Hospital Infantil Sabará - Instituto PENSI - Pesquisa e Ensino em Saúde Infantil
NOT_YET_RECRUITING

São Paulo, São Paulo, 01227-200, Brazil
Hospital Infantil de México "Dr. Federico Gómez"
NOT_YET_RECRUITING

México D.F., Mexico City, 6720, Mexico
Hospital Italiano de Buenos Aires
RECRUITING

Buenos Aires, C1199ABB, Argentina
Hospital PUC-Campinas | Centro de Pesquisa Clínica Sao Lucas
RECRUITING

São Paulo, São Paulo, 13034-685, Brazil
Hospital Pequeno Principe
NOT_YET_RECRUITING

Curitiba, Paraná, 80250-060, Brazil
Hospital Sant Joan De Deu Barcelona | Nefrologia pediatrica
COMPLETED

Barcelona, 08950, Spain
Hospital Santa Maria | Centro de Investigacao Clinica
NOT_YET_RECRUITING

Lisbon, 1649-035, Portugal
Hospital Selayang
NOT_YET_RECRUITING

Shah Alam, Selangor, 68100, Malaysia
Hospital Tuanku Ja'afar
RECRUITING

Seremban, Negeri Sembilan, 70300, Malaysia
Hospital Tunku Azizah
RECRUITING

Wilayah Persekutuan Putrajaya, Kuala Lumpur, 50300, Malaysia
Hospital Universitari Vall D Hebron | Nefrologia pediatrica
RECRUITING

Barcelona, 08035, Spain
Hospital Universitario "José Eleuterio González"
NOT_YET_RECRUITING

Monterrey, Nuevo León, 64460, Mexico
Hospital Universitario 12 De Octubre | Nefrologia pediatrica
RECRUITING

Madrid, 28041, Spain
Hospital Universitario La Paz | Nefrologia pediatrica
RECRUITING

Madrid, 28046, Spain
Hospital Universitario Regional De Malaga | Nefrologia pediatrica
RECRUITING

Málaga, 29010, Spain
Hospital Universitario Virgen Del Rocio S.L. | Nefrologia pediatrica
COMPLETED

Seville, 41013, Spain
Hospital Universiti Sains Malaysia
RECRUITING

Kelantan, Kelantan, 16150, Malaysia
Hospital de Niños Sor María Ludovica
WITHDRAWN

La Plata, Buenos Aires, 1900, Argentina
Hospital de Pediatría Juan P. Garrahan
WITHDRAWN

Buenos Aires, C1249ABN, Argentina
Hospital of LT University of Health Sciences Kaunas Clinics
RECRUITING

Kaunas, Kaunas County, LT-50161, Lithuania
Huderf / Ukzkf
NOT_YET_RECRUITING

Brussels, Brussels Capital, 1020, Belgium
Hôpital des Enfants
RECRUITING

Toulouse, Occitanie, 31059, France
IRCCS Istituto Giannina Gaslini - Nefrologia e Trapianto Rene
RECRUITING

Genoa, Liguria, 16147, Italy
Instituto Nacional de Pediatría
NOT_YET_RECRUITING

México, D.F., Mexico City, 4530, Mexico
Instituto Veracruzano en Investigación Clinica SC
NOT_YET_RECRUITING

Veracruz, 91900, Mexico
Instituto da Crianca e do Adolescente
NOT_YET_RECRUITING

São Paulo, São Paulo, 05403 000, Brazil
Instytut "Pomnik - Centrum Zdrowia Dziecka"
RECRUITING

Warsaw, 04-730, Poland
Instytut Centrum Zdrowia Matki Polki
COMPLETED

Lodz, 93-338, Poland
Ippokratio General Hospital Of Thessaloniki-Pediatric Nephrology Unit, 3rd Department of Paediatrics
WITHDRAWN

Thessaloniki, 54642, Greece
Istanbul Faculty of Medicine, Department of Internal Medicine, Department of Pediatrics
RECRUITING

Istanbul, 34093, Turkey (Türkiye)
Istanbul Universitesi Cerrahpasa - Cocuk Nefrolojisi
RECRUITING

Istanbul, 34098, Turkey (Türkiye)
Kaohsiung Veterans General Hospital
WITHDRAWN

Kaohsiung City, 813414, Taiwan
Karolinska University Hospital
WITHDRAWN

Stockholm, Stockholm County, 141 86, Sweden
Kepler Universitätsklinikum Campus IV
COMPLETED

Innsbruck, Tyrol, 6020, Austria
Kindernierenzentrum Bonn
WITHDRAWN

Bonn, North Rhine-Westphalia, 53127, Germany
Kindernierenzentrum Bonn
ACTIVE_NOT_RECRUITING

Bonn, North Rhine-Westphalia, 53127, Germany
Klaipeda Children's Hospital
NOT_YET_RECRUITING

Klaipėda, Klaipėda County, LT-92140, Lithuania
Korea University Guro Hospital
WITHDRAWN

Seoul, 08308, South Korea
Kyungpook National University Hospital
COMPLETED

Daegu, 41944, South Korea
Lucille Packard Children's Hospital Stanford - Pediatric Nephrology
RECRUITING

Palo Alto, California, 94304, United States
MHAT prof. Stoyan Kirkovitch AD
WITHDRAWN

Stara Zagora, Stara Zagora Province, 6003, Bulgaria
Manchester University NHS Foundation Trust | Royal Manchester Children's Hospital - Clinical Research Facility
RECRUITING

Manchester, Greater Manchester, M13 9WL, United Kingdom
Many Locations
NOT_YET_RECRUITING

Multiple Locations, Argentina
Many Locations
RECRUITING

Multiple Locations, Austria
Many Locations
RECRUITING

Multiple Locations, Belgium
Many Locations
RECRUITING

Multiple Locations, Czechia
Many Locations
RECRUITING

Multiple Locations, Denmark
Many Locations
RECRUITING

Multiple Locations, Finland
Many Locations
RECRUITING

Multiple Locations, France
Many Locations
RECRUITING

Multiple Locations, Germany
Many Locations
RECRUITING

Multiple Locations, Greece
Many Locations
RECRUITING

Multiple Locations, Hungary
Many Locations
RECRUITING

Multiple Locations, Israel
Many Locations
RECRUITING

Multiple Locations, Italy
Many Locations
RECRUITING

Multiple Locations, Lithuania
Many Locations
NOT_YET_RECRUITING

Multiple Locations, Netherlands
Many Locations
RECRUITING

Multiple Locations, Poland
Many Locations
RECRUITING

Multiple Locations, South Korea
Many Locations
RECRUITING

Multiple Locations, Spain
Many Locations
NOT_YET_RECRUITING

Multiple Locations, Sweden
Many Locations
RECRUITING

Multiple Locations, Switzerland
Many Locations
RECRUITING

Multiple Locations, Turkey (Türkiye)
Many Locations
RECRUITING

Multiple Locations, United Kingdom
Marmara University Medical Faculty | Pediatric Nephrology
RECRUITING

Istanbul, 34899, Turkey (Türkiye)
Mavani Kidney Care
NOT_YET_RECRUITING

Ahmedabad, Gujarat, 380052, India
Medizinische Hochschule Hannover (MHH) | Zentrum Innere Medizin | Klinik fuer Kardiologie und Angiologie
WITHDRAWN

Hanover, Lower Saxony, 30625, Germany
Medizinische Universität Graz
NOT_YET_RECRUITING

Graz, Styria, 8036, Austria
Memorial Transplant Institute - Pediatric Nephrology
NOT_YET_RECRUITING

Hollywood, Florida, 33021, United States
Monash Children's Hospital
WITHDRAWN

Clayton, Victoria, 3168, Australia
NHS Greater Glasgow and Clyde | Royal Hospital for Children - Glasgow Clinical Research Facility
RECRUITING

Glasgow, Scotland, G51 4TF, United Kingdom
NRS Medical college
ACTIVE_NOT_RECRUITING

Kolkata, West Bengal, 700014, India
National Cheng Kung University Hospital
WITHDRAWN

Tainan, 704, Taiwan
National Taiwan University Hospital
NOT_YET_RECRUITING

Taipei, 100229, Taiwan
Nottingham University Hospitals NHS Trust | Queens Medical Centre - Childrens Clinical Research Facility
WITHDRAWN

Nottingham, Nottinghamshire, NG7 2UH, United Kingdom
OBSOLETE_Uppsala University Hospital
WITHDRAWN

Uppsala, Uppsala County, 751 85, Sweden
OHSU Doernbecher Children's Hospital - Neurology
NOT_YET_RECRUITING

Portland, Oregon, 97239, United States
Odense Universitetshospital - HC Andersen Børne og Ungehospital
ACTIVE_NOT_RECRUITING

Odense, Region Syddanmark, 5000, Denmark
Ospedale Pediatrico Bambino Gesù - Nefrologia
RECRUITING

Rome, Lazio, 00165, Italy
Pecsi Tudomanyegyetem Klinikai Kozpont
COMPLETED

Pécs, Baranya, 7623, Hungary
Phoenix Children's Hospital | Main - Transplant Department
WITHDRAWN

Phoenix, Arizona, 85016, United States
Pusan National University Yangsan Hospital
RECRUITING

Yangsan, Gyeongsangnam-do, 50612, South Korea
Queensland Children's Hospital
RECRUITING

South Brisbane, Queensland, 4101, Australia
Rady Children's Hospital San Diego - Cardiology
NOT_YET_RECRUITING

San Diego, California, 92123, United States
Rigshospitalet - Børn og Unge
NOT_YET_RECRUITING

Copenhagen, Capital Region, 2100, Denmark
Royal Children's Hospital Melbourne
RECRUITING

Parkville, Victoria, 3052, Australia
SHATPD "Prof. Ivan Mitev"
NOT_YET_RECRUITING

Sofia, Sofia City Province, 1606, Bulgaria
Santa Casa de Misericórdia de Belo Horizonte
RECRUITING

São Paulo, São Paulo, 30150-221, Brazil
Seattle Children's Hospital - Nephrology
NOT_YET_RECRUITING

Seattle, Washington, 98105, United States
Semmelweis University
ACTIVE_NOT_RECRUITING

Budapest, 1083, Hungary
Seoul National University Bundang Hospital
COMPLETED

Seongnam-si, Gyeonggi-do, 13620, South Korea
Seoul National University Hospital
RECRUITING

Seoul, 03080, South Korea
Sitio Alfredo Chew Wong | Aguascalientes, Mexico
NOT_YET_RECRUITING

Aguascalientes, Agguascalientes, 20124, Mexico
Skånes Universitetssjukhus - Lund - Barnnefroenheten
ACTIVE_NOT_RECRUITING

Lund, Skåne County, 221 85, Sweden
St. John's National Academy of Health Sciences
RECRUITING

Bengaluru, Karnataka, 560034, India
Sunway Medical Centre
RECRUITING

Subang Jaya, Selangor, 47500, Malaysia
Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ
WITHDRAWN

Szeged, Csongrád-Csanád, 6720, Hungary
T.C. Saglik Bakanligi Ankara Bilkent Sehir Hastanesi Noroloji ve Ortopedi Hastanesi Noroloji Bolumu
RECRUITING

Ankara, 6800, Turkey (Türkiye)
Taipei Veterans General Hospital
NOT_YET_RECRUITING

Taipei, 11217, Taiwan
Tampere University Hospital, Tampereen yliopistollinen sairaala (TAYS) - Lasten lääketutkimuskeskus PeeTU
RECRUITING

Tampere, Pirkanmaa, 33521, Finland
The Charlotte R. Bloomberg Children's Center Building - Nephrology
RECRUITING

Baltimore, Maryland, 21287, United States
The Hospital for Sick Children (SickKids)
NOT_YET_RECRUITING

Toronto, Ontario, M5G 1X8, Canada
Turun yliopistollinen keskussairaala
WITHDRAWN

Turku, Southwest Finland, 20520, Finland
UMHAT Sveti Georgi
NOT_YET_RECRUITING

Plovdiv, Plovdiv Province, 4002, Bulgaria
UZ Gasthuisberg - Pediatric Nephrology
RECRUITING

Leuven, Flemish Brabant, 3000, Belgium
UZ Gent
RECRUITING

Ghent, East Flanders, 9000, Belgium
Unidade Local de Saúde de Braga E.P.E. - Centro Clínico Académico de Braga - Serviço de Pediatria
WITHDRAWN

Braga, 4710-243, Portugal
Unidade Local de Saúde de Coimbra, E.P.E. - Hospital Pediátrico - Serviço de Pediatria Ambulatória - Nefrologia
RECRUITING

Coimbra, 3000, Portugal
Unidade Local de Saúde de Santo António, E.P.E
RECRUITING

Porto, 4050-651, Portugal
Uniklinikum Salzburg - Landeskrankenhaus
NOT_YET_RECRUITING

Vienna, State of Vienna, 1090, Austria
Universitair Medisch Centrum Groningen
RECRUITING

Groningen, 9713 GZ, Netherlands
University General Hospital Of Ioannina-Child Health Sector
RECRUITING

Ioannina, 45500, Greece
University General Hospital of Heraklion
RECRUITING

Heraklion, 71110, Greece
University Hospital - San Antonio - Pediatric Nephrology
WITHDRAWN

San Antonio, Texas, 78207, United States
University Medical Center Utrecht
RECRUITING

Utrecht, 3584 CX, Netherlands
University of Iowa Health Care Medical Center - Nephrology
WITHDRAWN

Iowa City, Iowa, 52242, United States
Universitäts-Kinderspital UKBB
RECRUITING

Basel, Canton of Basel-City, 4031, Switzerland
Universitätsklinikum AKH Wien
NOT_YET_RECRUITING

Vienna, State of Vienna, 1090, Austria
Universitätsklinikum Erlangen
WITHDRAWN

Erlangen, Bavaria, 91054, Germany
Universitätsklinikum Essen
ACTIVE_NOT_RECRUITING

Essen, North Rhine-Westphalia, 45147, Germany
Universitätsklinikum Hamburg Eppendorf (UKE)
SUSPENDED

Hamburg, 20246, Germany
Universitätsklinikum Heidelberg
WITHDRAWN

Heidelberg, Baden-Wurttemberg, 69115, Germany
Universitätsklinikum Münster
WITHDRAWN

Münster, North Rhine-Westphalia, 48149, Germany
Uniwersytecki Dzieciecy Szpital Kliniczny im. L. Zamenhofa
COMPLETED

Bialystok, 15-274, Poland
Uniwersytecki Szpital Dzieciecy w Krakowie
WITHDRAWN

Krakow, 30-663, Poland
Uniwersytecki Szpital Kliniczny Im. Jana Mikulicza-Radeckiego We Wroclawiu
WITHDRAWN

Wroclaw, 50-556, Poland
Uniwersyteckie Centrum Kliniczne
RECRUITING

Gdansk, 80-952, Poland
Vilnius University Hospital Santaros Klinikos Children's Hospital Paediatrics Centre
RECRUITING

Vilnius, Vilnius County, LT-08406, Lithuania
Všeobecná fakultní nemocnice v Praze
RECRUITING

Prague, Prague, 128 08, Czechia
Wilf Children's Hospital Shaare Zedek Medical Center
RECRUITING

Jerusalem, 9103102, Israel
Wits Vaccines & Infectious Diseases Analytics (VIDA) Research Unit
NOT_YET_RECRUITING

Soweto, Gauteng, 1862, South Africa