New hope for kids on dialysis: drug targets hormone imbalance

NCT ID NCT03633708

Recruiting now Disease control Sponsor: Amgen Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial tests etelcalcetide (Parsabiv) in 56 children aged 28 days to under 18 years who have secondary hyperparathyroidism and chronic kidney disease and are on hemodialysis. The drug aims to lower parathyroid hormone levels and improve mineral balance. Participants receive either etelcalcetide or standard care (vitamin D, calcium, phosphate binders) to compare effectiveness and safety.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: etelcalcetide (Parsabiv)
What this could lead to: If it works, this could provide a new treatment option to better control hormone levels and mineral balance in children with kidney disease on dialysis.
What could go wrong: This is a relatively small trial (56 kids) and the drug is already approved for adults, but children may respond differently or have unexpected side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

chronic kidney disease chronic renal failure syndrome secondary hyperparathyroidism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC KIDNEY DISEASE SECONDARY HYPERPARATHYROIDISM

Contacts and locations

Show contact details

Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

All India Institute of Medical Sciences
ACTIVE_NOT_RECRUITING

New Delhi, National Capital Territory of Delhi, 110029, India
Ankara Bilkent Sehir Hastanesi
RECRUITING

Ankara, 06800, Turkey (Türkiye)
Asan Medical Center
TERMINATED

Seoul, 05505, South Korea
Baskent Universitesi Ankara Hastanesi
RECRUITING

Ankara, 06490, Turkey (Türkiye)
Centro Infantil Del Rinon
RECRUITING

San Miguel de Tucumán, Tucumán Province, 4000, Argentina
Childrens Hospital Colorado
TERMINATED

Aurora, Colorado, 80045, United States
Childrens Hospital of Los Angeles
RECRUITING

Los Angeles, California, 90027, United States
Childrens Hospital of Philadelphia
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Childrens Medical Center Dallas
TERMINATED

Dallas, Texas, 75390, United States
Childrens Mercy Hospital
RECRUITING

Kansas City, Missouri, 64108, United States
Cincinnati Childrens Hospital Medical Center
COMPLETED

Cincinnati, Ohio, 45229, United States
Cleveland Clinic Foundation
RECRUITING

Cleveland, Ohio, 44195, United States
Ege Universitesi Tip Fakultesi Hastanesi
RECRUITING

Izmir, 35040, Turkey (Türkiye)
Erciyes Universitesi Tip Fakultesi Hastanesi
RECRUITING

Kayseri, 38039, Turkey (Türkiye)
Firat Universitesi Tip Fakultesi Hastanesi
RECRUITING

Elâzığ, 23200, Turkey (Türkiye)
Fortis Flt Lt Rajan Dhall Hospital
ACTIVE_NOT_RECRUITING

New Delhi, National Capital Territory of Delhi, 110 070, India
Fresenius Escobar
TERMINATED

Belen de Escobar, Buenos Aires, B1625DUG, Argentina
Gazi Universitesi Saglik Arastirma ve Uygulama Merkezi Gazi Hastanesi
RECRUITING

Ankara, 06500, Turkey (Türkiye)
Hacettepe Universitesi Tip Fakultesi Hastanesi
RECRUITING

Ankara, 06230, Turkey (Türkiye)
Hospital Italiano
RECRUITING

Cuidad Autonoma de Buenos Aires, Buenos Aires, C1199ABB, Argentina
Hospital Raja Perempuan Zainab II
TERMINATED

Kota Bharu, Kelantan, 15586, Malaysia
Hospital TuanKu Jaafar
TERMINATED

Seremban, Negeri Sembilan, 70300, Malaysia
Hospital Wanita Dan Kanak-Kanak Kuala Lumpur
TERMINATED

Kuala Lumpur, Kuala Lumpur, 50300, Malaysia
Istanbul Universitesi Cerrahpasa Tip Fakultesi
RECRUITING

Istanbul, 34098, Turkey (Türkiye)
KLES Dr Prabhakar Kore Hospital and Medical Research Centre
ACTIVE_NOT_RECRUITING

Belagavi, Karnataka, 590010, India
Kaohsiung Veterans General Hospital
TERMINATED

Kaohsiung City, 81362, Taiwan
Linkou Chang Gung Memorial Hospital
RECRUITING

Taoyuan, 33305, Taiwan
Manipal Hospital
ACTIVE_NOT_RECRUITING

Bangalore, Karnataka, 560 017, India
Marmara Universitesi Tip Fakultesi Hastanesi
RECRUITING

Istanbul, 34890, Turkey (Türkiye)
Mount Sinai Kidney Center - B1 Renal Treatment
COMPLETED

New York, New York, 10029, United States
NRS Medical College and Hospital
ACTIVE_NOT_RECRUITING

Kolkata, West Bengal, 700014, India
National Cheng Kung University Hospital
TERMINATED

Tainan, 70403, Taiwan
National Childrens Specializated Hospital Okhmadit
TERMINATED

Kyiv, 01135, Ukraine
National Taiwan University Hospital
RECRUITING

Taipei, 10041, Taiwan
National University Hospital
RECRUITING

Singapore, 119074, Singapore
Primary Childrens Hospital Outpatient Services
RECRUITING

Salt Lake City, Utah, 84113, United States
Pusan National University Yangsan Hospital
TERMINATED

Yangsan-si, Gyeongsangnam-do, 50612, South Korea
SBHI Children's City Multidisciplinary Clinical Specialized Center of High Medical Technologies
COMPLETED

Saint Petersburg, 198205, Russia
SBHI Pediatrics city clinical hospital of Saint Vladimir
TERMINATED

Moscow, 107014, Russia
Seoul National University Hospital
TERMINATED

Seoul, 110-744, South Korea
Sir Ganga Ram Hospital
ACTIVE_NOT_RECRUITING

New Delhi, National Capital Territory of Delhi, 110060, India
State Budgetary Healthcare Institution Samara Regional Clinical Hospital na V D Seredavin
TERMINATED

Samara, 443095, Russia
The Childrens Hospital at Oklahoma University Medical Center
COMPLETED

Oklahoma City, Oklahoma, 73104, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.