TYPE 2 DIABETES MELLITUS

This study will see if a program led by community health workers (CHWs) can help people with type 2 diabetes in rural and low-income clinics. About 200 Spanish-speaking Hispanic adults will attend monthly diabetes classes and get weekly check-ins from CHWs. The goal is to see if …

This pilot trial tests whether a 4-week group education program that blends Chinese medicine concepts—like body constitution, dietary therapy, and acupressure—with standard diabetes self-management training is feasible and acceptable for adults with type 2 diabetes in Hong Kong. …

This trial is testing whether taking a daily Ceylon cinnamon supplement, combined with a structured educational program, can improve blood sugar control, cholesterol levels, and nerve pain in adults with type 2 diabetes and painful diabetic peripheral neuropathy. About 900 partic…

This phase II trial is testing whether an experimental oral medication, DA-302168S, can help people with type 2 diabetes control their blood sugar. The study will compare the drug against a placebo in about 272 adults who are already taking metformin. Researchers will measure cha…

This study tests whether using ultrasound to push propolis (a natural bee product) into the skin can help heal diabetic foot ulcers faster. Eighty adults with diabetes and foot ulcers will either get propolis plus ultrasound or standard wound care for 4 weeks. The goal is to see …

This study tests whether two low-calorie versions of the MIND-HK diet can improve blood sugar and heart health in adults with type 2 diabetes. 180 participants aged 40-70 will be split into three groups: one following a low-calorie diet, one a very low-calorie diet, and a control…

This trial investigates whether adding a PCSK9 inhibitor to a high-intensity statin can reduce liver fat—measured by a non-invasive FibroScan—in diabetic patients who have recently had a heart attack or unstable angina. Half the participants will receive the combination therapy, …

This trial explores whether starting transdermal estradiol (a skin gel or patch) soon after menopause can protect the heart and brain in women who have hot flashes and at least one cardiovascular risk factor. One hundred women will be randomly assigned to receive the hormone ther…

This study tests a smart computer system that helps primary care doctors screen for and manage diabetic kidney disease in adults with type 2 diabetes. The tool automatically calculates kidney function, reminds doctors to order urine tests, and gives personalized treatment advice.…

This study tests whether secukinumab, a drug that blocks inflammation, can reduce the risk of major heart problems and kidney decline in people with cardiorenal metabolic syndrome and hardened arteries. About 100 adults will receive either secukinumab injections plus standard car…

This study tests whether a home-based balance and strength program called Otago exercises can improve mobility, balance, and quality of life in adults with type 2 diabetes. Participants do the exercises 5 days a week for 4 weeks, plus walking. The trial measures how quickly they …

This early-stage trial is testing whether injecting placental stem cells into and around non-healing diabetic foot ulcers is safe. The study involves 12 people with Type 2 diabetes who have a foot ulcer that has not healed for at least four weeks despite standard care. Researcher…

This study tests whether adding blood flow restriction (BFR) training to standard exercise helps adults aged 50-60 with type 2 diabetes improve balance, muscle strength, and physical function. Participants wear compression cuffs on their limbs during low-intensity resistance exer…

This study tests a procedure called pulsENDO that uses mild electric pulses to regenerate the lining of the first part of the small intestine (duodenum) in people recently diagnosed with type 2 diabetes. The goal is to see if this can help control blood sugar levels without needi…

This study tests whether a deep dental cleaning (subgingival instrumentation) can slow the progression of chronic kidney disease in 40 adults with diabetes and stage IV-V kidney disease. The cleaning aims to reduce inflammation that may worsen kidney function. Researchers will me…

This study tests a new injectable drug called SRSD384 in 78 overweight or obese adults. In the first part, participants receive a single dose of SRSD384 alone. In the second part, they receive SRSD384 combined with another weight-loss drug, tirzepatide. The main goal is to check …

This study tests a modified oral rehydration salts (ORS) drink designed for diabetic pilgrims at risk of heat stress and dehydration during the Hajj. The modified ORS has adjusted electrolytes and carbohydrates to avoid raising blood sugar. Researchers will compare it to standard…

This study tests whether starting treatment with two experimental drugs together (DWP16001 and DWC202518) works better than either drug alone for people with type 2 diabetes. About 510 adults will take the combo or a single drug for 24 weeks, and researchers will measure changes …

This study will compare three approaches before gastric bypass surgery for severe obesity: taking the medication tirzepatide for 60 days, following a ketogenic diet for 4 weeks, or receiving standard care. The goal is to see which method leads to the most weight loss one year aft…

This study tests a new way to deliver insulin for type 2 diabetes: a spray applied to the skin instead of an injection. Thirty adults who already use insulin will try the spray for 21 days. Researchers will check if it keeps blood sugar in a safe range and causes less skin irrita…

This study compares two glucose monitoring methods—continuous glucose monitors (CGM) and traditional finger-prick tests—in adults with type 2 diabetes who are taking the drug dapagliflozin. The 120 participants will be split into two groups and followed for 12 weeks to see which …

This study compares a two-drug combination (dapagliflozin plus finerenone) against dapagliflozin alone in 88 adults with type 2 diabetes and chronic kidney disease. The goal is to see if the combo better reduces protein in urine, a key sign of kidney damage. Participants take pil…

This study tests a 12-week home exercise program combining aerobic and resistance training for older adults (60+) with type 2 diabetes and early muscle weakness. The goal is to see if short, regular workouts can improve physical activity levels and muscle strength. About 73 parti…

This study tests whether tributyrin, a dietary supplement that turns into butyrate in the body, can improve blood sugar control, reduce inflammation, and lower heart disease risk in people with type 2 diabetes. Sixty participants at high risk for heart problems will receive eithe…

This study tests whether a supplement called HMB, combined with exercise, can improve muscle mass, strength, and insulin resistance in older adults (ages 60-80) with type 2 diabetes and low muscle mass. Participants will be randomly assigned to receive HMB, exercise, both, or pla…

This study will test the safety and effectiveness of tirzepatide, a once-weekly injection, in 300 adults with obesity or overweight plus related health problems. Participants will receive increasing doses over 12 months while doctors track side effects, weight loss, and improveme…

This study tests a procedure that uses radiofrequency energy to disable certain nerves near the kidneys and abdomen. The goal is to see if this can safely lower blood pressure and improve blood sugar control in 20 adults with resistant hypertension and type 2 diabetes who have no…

This study tests a new approach to managing type 2 diabetes that combines an AI smartphone app with support from family doctors. About 1200 adults in China will use the app to track their meals and get personalized feedback, while also receiving regular check-ins from their docto…

This study tests a community-based exercise program for people aged 50 and older who have at least two chronic conditions, such as heart disease, diabetes, arthritis, or obesity. The program is designed to improve muscle strength, heart and lung fitness, and overall well-being. R…

This study looks at whether two common diabetes drugs, GLP-1 analogs and SGLT2 inhibitors, can reduce osteoarthritis symptoms like joint pain and stiffness in people with type 2 diabetes. Researchers will follow 390 adults over 50 who have been on one of these drugs for at least …

This study tests whether the drug finerenone can slow kidney function decline and lower heart failure risk in 120 adults with type 2 diabetes and chronic kidney disease. Participants must already be on standard blood pressure medications. The study will measure changes in kidney …

This study tests an experimental drug, DA-2811, in 288 adults with type 2 diabetes whose blood sugar is not well controlled despite taking two other diabetes medications. Participants will receive either DA-2811 or a placebo added to their current treatment. The main goal is to s…

This study tests whether a diabetes drug called sentagliptin (a DPP4 inhibitor) can improve thinking and memory in people who have had a mild stroke and also have type 2 diabetes. About 312 participants will receive either the drug or a placebo daily for 180 days. Researchers wil…

This study looks at whether common diabetes drugs called SGLT2 inhibitors (like empagliflozin and dapagliflozin) can improve the structure and function of the heart's left atrium in people with type 2 diabetes. Researchers will use advanced ultrasound to measure heart changes in …

This study tests whether eating four GlucoBites cookies daily for 12 weeks can improve blood sugar control and reduce the risk of diabetic foot ulcers in adults with type 2 diabetes. The cookies contain an herb called Gynura procumbens. Researchers will compare blood sugar, insul…

This trial investigates whether a nasal spray containing insulin can prevent postoperative delirium—a sudden, temporary state of confusion—in older adults (65+) with type 2 diabetes who are undergoing liver tumor surgery. Participants are randomly assigned to receive one of two d…

This study tests whether a structured cognitive training program can improve memory, attention, and other thinking skills in older adults who have type 2 diabetes and mild cognitive impairment. Participants will be randomly assigned to either the cognitive intervention or a contr…

This study investigates whether a device called FREMS, which delivers rhythmic electrical pulses to the legs, can improve blood flow, reduce nerve pain and numbness, and enhance quality of life in people with type 2 diabetes who have peripheral neuropathy and poor leg circulation…

This study tests whether taking vitamin D supplements can reduce nerve pain, improve sleep, and boost quality of life in people with type 2 diabetes who have nerve damage. Researchers will give vitamin D to 150 adults with low vitamin D levels and track their pain and sleep over …

This study will test whether a single dose of beetroot juice can improve blood pressure and heart rate recovery after light cycling in adults with type 2 diabetes. About 20 participants aged 40-65 will receive either beetroot juice or a placebo in random order. The goal is to see…

This study will test a virtual reality program called 'Health for My Feet' for people with type 2 diabetes. The program aims to teach foot care through VR goggles and includes weekly reminder messages. Researchers will compare foot care knowledge, self-care habits, and foot healt…

This pilot study looks at whether it is safe and practical for pregnant women with type 1 or type 2 diabetes to continue using their insulin pump during labor, instead of switching to IV insulin. About 30 women who already use an insulin pump will be allowed to keep using it whil…

This study tests whether low-level laser therapy or muscle energy techniques work better for reducing pain and improving shoulder movement in people with type 2 diabetes who have frozen shoulder. Thirty-six adults aged 18 to 65 will receive one of the two treatments plus standard…

This study compares using an injection port versus standard needles for insulin delivery in pregnant women with diabetes. The port stays on the skin for three days, allowing insulin to be given without repeated needle sticks. Researchers want to see if this approach helps women s…

This observational study is investigating whether vitamin D levels are linked to cholesterol and other blood fats in obese adults with type 2 diabetes. Researchers will measure vitamin D status and lipid profiles in 150 participants from a diabetes clinic in Cairo. No treatments …

This study investigates whether the speed at which blood sugar falls after starting a new diabetes medicine affects small blood vessels in the eye. Adults with type 2 diabetes who are beginning a GLP-1 receptor agonist or an SGLT2 inhibitor will undergo advanced eye scans and blo…

This study follows 425 adults with type 2 diabetes and chronic kidney disease who are taking finerenone, a standard medication. Researchers collect blood and urine samples over four months to look for biomarkers that predict whether the drug helps reduce kidney damage. The goal i…

This study investigates whether insulin resistance, measured by the TyG index, is linked to the no-reflow phenomenon—where blood flow fails to restore properly—after primary PCI (stenting) for heart attacks in people with type 2 diabetes. Researchers will also examine how insulin…

This study tests whether a large language model (LLM) — a type of AI — can help village doctors make better care plans for patients with type 2 diabetes and high blood pressure. About 20 rural doctors will review standardized patient cases, with half receiving AI-assisted decisio…

This study will test how accurate and safe two continuous glucose monitoring (CGM) systems, the Anytime 5Pro and Anytime 4Pro, are in adults with type 1 or type 2 diabetes. About 70 participants will wear both devices at the same time and have their blood sugar measured during cl…

This study uses the FreeStyle Libre 2, a small sensor worn on the arm, to track blood sugar changes in 120 people with rare forms of diabetes, including monogenic diabetes and hyperinsulinemia. Researchers will compare these patterns with data from healthy people and those with t…

This study looks at how ups and downs in blood sugar affect diabetic patients admitted to the coronary care unit. Researchers will track 120 adults with diabetes and heart disease to see if glucose variability increases the risk of death or major heart problems like heart attack …

This study looks at whether a substance in the blood called neurofilament light chain (NfL) is linked to how severe nerve damage is, how well people balance, and their risk of falling. Researchers will measure NfL levels in 80 adults with type 2 diabetes, some with and some witho…

This study looks at why some people with type 2 diabetes develop painful nerve damage while others do not. Researchers will measure how the central nervous system processes pain in 128 adults aged 18-80 who have had diabetes for at least one year. The goal is to better understand…

This 10-year observational study will follow 10,000 adults with diabetes, metabolic disorders, and related conditions like high blood pressure and fatty liver disease. Researchers will collect routine medical data to identify markers of disease severity and activity. The goal is …

This study will check heart disease risk scores in 238 adults with type 2 diabetes who are 40 or older. Researchers want to see if simple, non-invasive measures of belly fat (called LAP and VAI) are linked to higher cardiovascular risk. The goal is to find easier ways to identify…

This study will follow 460 diabetes patients who take semaglutide to see if those with nerve damage (neuropathy) are more likely to develop stomach retention, where food stays in the stomach too long. Participants will have a stomach exam to check for retained food or liquid. The…