Can a nasal spray of insulin shield the aging brain from Post-Surgery confusion?

NCT ID NCT07720479

Not yet recruiting Prevention Sponsor: Weidong Mi Source: ClinicalTrials.gov ↗

First seen Jul 22, 2026 · Last updated Jul 23, 2026 · Updated 1 time

Summary

This trial investigates whether a nasal spray containing insulin can prevent postoperative delirium—a sudden, temporary state of confusion—in older adults (65+) with type 2 diabetes who are undergoing liver tumor surgery. Participants are randomly assigned to receive one of two doses of intranasal insulin or a placebo spray before and after surgery. The study aims to see if improving the brain's response to insulin can reduce the risk of delirium and early cognitive decline.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: intranasal insulin (human insulin given as a nasal spray)
What this could lead to: If it works, this could offer a simple, non-invasive way to prevent postoperative delirium in older adults with diabetes.
What could go wrong: This is an early-stage trial with a small sample size. The optimal dose is unknown, and intranasal insulin may cause nasal irritation or hypoglycemia.

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Conditions

The condition(s) this trial relates to.

Emergence Delirium type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POSTOPERATIVE DELIRIUM (POD)

Contacts and locations

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Study contacts

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Phone: •••-•••-•••• Email: •••••@•••••

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