TYPE 2 DIABETES MELLITUS

This early-stage study tests whether the drug RO7204239 can improve how the body uses insulin in people with type 2 diabetes who are also overweight or obese. About 30 participants will receive either the drug or a placebo for 24 weeks. The main goal is to measure changes in insu…

This study looks at how the weekly drug retatrutide affects recovery from low blood sugar (hypoglycemia) in people with type 2 diabetes. About 78 adults on metformin will receive either retatrutide or a placebo for 16 weeks. Researchers will measure how quickly blood sugar return…

This study compares two different three-drug combinations for adults newly diagnosed with type 2 diabetes. 110 people aged 30-55 will take one of the combos daily for 90 days. Researchers will check blood sugar, weight, and safety at regular visits to see which combo works better…

This study compares laparoscopic sleeve gastrectomy (a type of weight-loss surgery) with standard medical treatment in 30 adults who are newly diagnosed with type 2 diabetes and have a BMI between 30 and 42. The goal is to see if surgery can help more people achieve diabetes remi…

This study tracks 200 adults with type 2 diabetes to see if enavogliflozin helps them lose weight over 24 weeks. Participants take the drug as part of their normal care. The main goals are changes in body weight and BMI. This is an observational study, not a cure, but aims to imp…

This study tests whether the drug JY09 can help control blood sugar in people with type 2 diabetes who haven't been able to manage it with diet and exercise alone. About 270 adults will receive either JY09 or a placebo for up to 54 weeks. The main goal is to see if JY09 lowers Hb…

This study tests a new medicine, SHR-3167, against a standard long-acting insulin (insulin degludec) in 173 adults with type 2 diabetes who already use basal insulin. The goal is to see which treatment better controls blood sugar levels over time. Participants will continue their…

This study tests three ways to help older adults (60+) with type 2 diabetes who live in nursing homes manage their blood sugar. One group uses gentle electrical pulses on leg muscles, another does supervised exercise, and a third gets health education. The goal is to see which ap…

This study tests whether a weekly injection of semaglutide can help preserve the body's ability to make insulin and reduce fat buildup in the liver. It involves 60 obese youth with prediabetes or early type 2 diabetes who also have fatty liver disease. Participants receive the dr…

This study tests three common diabetes medications (liraglutide, empagliflozin, and linagliptin) to see if they can improve memory and thinking in people with type 2 diabetes who have mild cognitive impairment. About 396 adults aged 40-75 will take one of the drugs for 48 weeks, …

This study tests a new once-daily medicine called RO7795081 to see if it helps lower blood sugar in adults with type 2 diabetes. About 240 participants will take the study drug, a placebo (inactive pill), or an approved diabetes medicine (semaglutide) for 30 weeks. The main goal …

This study aimed to see if a lifestyle program called Lifestyle MIND could help people with serious mental illness manage or prevent type 2 diabetes. Participants would have been randomly assigned to join the program right away or wait. The study was withdrawn before any particip…

This study looks at whether the amount of effort during weightlifting changes blood sugar levels in people with prediabetes or type 2 diabetes. Fifteen adults will try a high-effort workout, a low-effort workout, and a rest day to compare blood sugar and how they feel. The goal i…

This study reviews medical records of 1,200 Indian adults with chronic kidney disease and type 2 diabetes who started taking finerenone between August 2022 and April 2024. Researchers will look at how doctors prescribed the drug, dose changes, and lab results like kidney function…

This study observes how sugars, fats, and proteins in breast milk differ among mothers and change over time. It also explores how these components, along with maternal diet and health, influence the development of the baby's gut bacteria. About 395 pregnant women who plan to brea…

This study looks at real-world data from 150,000 people with chronic kidney disease and type 2 diabetes to see how safe and effective the drug finerenone is in routine medical care. Researchers will compare heart problems like heart attacks and hospitalizations for heart failure …

This study looks at how an experimental drug called AZD6793 changes the way metformin works in people with type 2 diabetes. About 28 adults on a stable dose of metformin will take AZD6793 or a placebo for a short time, and researchers will measure blood sugar levels. The goal is …

This study looks at how exercise affects special cells that repair blood vessels in older veterans with pre-diabetes. Researchers will compare these cells in people with normal blood sugar, pre-diabetes, and type 2 diabetes. The goal is to see if aerobic exercise can improve cell…

This study looks at how low blood sugar (hypoglycemia) affects blood vessel function in people with type 2 diabetes and healthy adults. Researchers want to understand if a natural gut hormone called GLP-1 can change these effects. The goal is to learn more about the link between …

This study looks at whether being overweight or having diabetes changes certain chemical marks on sperm DNA. Researchers will check if a 3-month lifestyle or blood sugar program can improve these marks. The study involves 40 men aged 18-65 who are overweight, with or without diab…

This study watches how doctors prescribe finerenone to people with chronic kidney disease and type 2 diabetes in everyday care. It does not test a new treatment—just collects information from medical records and doctor visits over 12 months. About 4,600 adults will take part to h…