TYPE 2 DIABETES MELLITUS

This study looks at the safety and performance of the Endogenex System in 50 adults with type 2 diabetes. Participants previously received a sham (fake) procedure in an earlier study. The main goal is to track any serious side effects related to the device or procedure.

This study compares two types of weight-loss surgery (gastric bypass and gastric banding) with an intensive diet and exercise program for controlling type 2 diabetes in moderately obese adults aged 25 to 55. The goal is to see which approach works best for improving diabetes and …

This study looks at whether the amount of effort you put into strength training can improve blood sugar control and mental health in people with type 2 diabetes. About 48 adults with type 2 diabetes will do resistance exercises at different effort levels. Researchers will track b…

This early-stage study tests a new drug, maridebart cafraglutide, to see if it helps people with type 2 diabetes use insulin better. About 56 adults on metformin will receive either the drug or a placebo. The main goal is to measure changes in insulin sensitivity after 25 weeks.

This study looks at health records of 120,000 people with type 2 diabetes and overweight to compare two injectable drugs: semaglutide and dulaglutide. Researchers want to see which one better reduces the risk of death, heart attack, or stroke. The goal is to understand how these …

This study looks at whether 10 weeks of regular exercise (on land or in water) can lower blood sugar and blood pressure in people aged 60 and older who have several health conditions like diabetes, high blood pressure, and arthritis. 63 volunteers will be split into two exercise …

This study tests three different non-drug approaches to help older adults in nursing homes manage their type 2 diabetes. One group uses a device that sends mild electrical pulses to the leg muscles, another does supervised exercise, and the third receives health education. The ma…

This early-stage trial is studying whether an experimental drug called AZD6793 changes how the common diabetes medicine metformin works in people with type 2 diabetes. About 28 participants will take both AZD6793 and a placebo alongside their usual metformin to compare effects on…

This study tests whether semaglutide (Wegovy), a once-weekly injection, can preserve the pancreas's ability to produce insulin and reduce liver fat in 60 obese youth with prediabetes or early type 2 diabetes and fatty liver disease. Participants receive either semaglutide or a pl…

This early-stage trial tests whether a drug called RO7204239 can improve how the body uses insulin and affects muscle composition in 30 adults with type 2 diabetes who are overweight or obese. Participants will receive either the drug or a placebo, and researchers will measure ch…

This Phase 2 study tests a new once-daily pill called RO7795081 for people with type 2 diabetes. About 240 adults whose diabetes is not well controlled will take the drug, a placebo, or an existing medication (semaglutide) for 30 weeks. The main goal is to see if RO7795081 lowers…

This study is testing the safety of the FreeStyle Libre 2, a device that continuously checks blood sugar levels, in 550 children and young adults aged 4 to 30 with type 1 or type 2 diabetes. The goal is to see if using this monitor reduces severe low blood sugar events that need …

This study was designed to test whether a program called Lifestyle MIND can help people with serious mental illness (like schizophrenia or bipolar disorder) prevent or manage type 2 diabetes. The program includes group exercise and health classes twice a week for 10 weeks. Howeve…

This study compares two different three-drug combinations for people newly diagnosed with type 2 diabetes. 110 adults aged 30-55 will take one of the combos daily for 90 days. Researchers will check blood sugar, weight, and safety over 6 months to see which combo works better.

This study tests a new way for cancer doctors and primary care doctors to work together to help cancer survivors manage other health problems like high blood pressure, diabetes, and high cholesterol. About 800 adults with certain cancers and at least one of these conditions will …

This study tests if weight-loss surgery (sleeve gastrectomy) can help people with newly diagnosed type 2 diabetes and a BMI of 30-42 achieve diabetes remission without medication. About 30 adults will be randomly assigned to either surgery or standard medical care and followed fo…

This study tests whether adding omega-3 supplements to standard diabetes treatment can improve blood sugar control and cholesterol levels in people with type 2 diabetes. About 66 adults aged 25-75 will take either omega-3 or a placebo twice daily for 12 weeks. Researchers will mo…

This study tests whether ketorolac, an anti-inflammatory eye drop, can reduce inflammation in the eyes of people with diabetic retinopathy and slow the disease. About 164 adults with type 2 diabetes will use either the active drop or a placebo for up to 3 years. Researchers will …

This study tests whether combining an AI smartphone app, intermittent fasting (16 hours of fasting daily), and resistance training can improve blood sugar control and physical fitness in people with type 2 diabetes. Sixty adults with diabetes will either follow this program or re…

This study tests whether three diabetes medications—liraglutide, empagliflozin, and linagliptin—can help reverse mild cognitive impairment (early memory and thinking problems) in people with type 2 diabetes. About 396 participants will take one of the drugs for 48 weeks, with an …

This study compares two different doses of vitamin D supplements in 108 adults with type 2 diabetes who also have low vitamin D levels. Researchers will measure changes in blood sugar and HbA1c over time to see if higher doses improve diabetes control. Participants must be aged 4…

This study tests whether sending text message reminders and education to pregnant women with diabetes helps them follow their care plan—like keeping appointments, tracking blood sugar, and taking medications. About 185 participants will be randomly assigned to receive texts or st…

This study tests whether a cookie made from Golden Rice and red betel leaf can improve cholesterol and triglyceride levels in adults with type 2 diabetes. Over 28 days, 102 participants will eat the cookies daily, and their blood fat levels will be measured before and after. The …

This study tests a snack bar made from red beans and tomatoes, called GlycoBite, in 100 people with type 2 diabetes. Participants eat one 40-gram bar daily for three weeks. Researchers check if it helps lower fasting blood sugar and HbA1c levels. The goal is to see if this simple…

This study tests a new insulin called GZR4 that is given once a week, compared to a standard daily insulin, in adults with type 2 diabetes who have never used insulin before. About 580 participants will receive either the weekly shot or daily insulin, along with their usual diabe…

This study tests a new insulin (GZR4) given just once a week, compared to a standard daily insulin (glargine), in 580 adults with type 2 diabetes who already use mealtime insulin. The goal is to see if the weekly shot controls blood sugar as well or better, with fewer injections …

This phase 3 study tests a new insulin called GZR4 that is injected just once a week, compared to the standard daily insulin degludec. About 620 adults with type 2 diabetes who already use basal insulin will take part. The goal is to see if the weekly shot controls blood sugar ju…

This study tests a new medication, SHR-3167, against a standard long-acting insulin (insulin degludec) in people with type 2 diabetes who already use basal insulin. The goal is to see which one controls blood sugar better and is safer. About 173 adults aged 18-65 with type 2 diab…

This phase 3 trial compares two doses of an experimental drug called JY09 against the approved drug dulaglutide in 600 adults with type 2 diabetes not well controlled by metformin alone. Participants receive either JY09 every two weeks or dulaglutide once a week for 54 weeks. The…

This phase 3 trial tests a new drug called JY09 in 270 adults with type 2 diabetes whose blood sugar is not well controlled by diet and exercise alone. Participants receive either JY09 or a placebo injection every two weeks for up to 54 weeks. The main goal is to see if JY09 lowe…

This study is looking at whether enavogliflozin, a diabetes medication, can help people with type 2 diabetes lose weight. Researchers will track 200 adults over 24 weeks in regular doctor visits. The main goal is to see changes in body weight and BMI, along with safety.

This study tests a new device called LabPatch that measures blood sugar from fluid just under the skin. About 60 adults with type 1 or type 2 diabetes who use insulin will wear the patch for 6 hours. Researchers will compare its readings to standard lab tests and two commercial g…

This study tests a new way to screen for type 2 diabetes by measuring sugar levels in fingernails. Researchers will compare results from 100 adults (half with known diabetes, half without) to standard blood tests. The goal is to see if this simple, non-invasive method can accurat…

This study compares high-effort versus low-effort resistance exercise sessions to see which better controls blood sugar in people with prediabetes or type 2 diabetes. Fifteen participants will complete both types of sessions plus a no-exercise control day, with blood sugar monito…

This study tests whether linaclotide (Linzess) can improve bowel movement frequency in people with type 2 diabetes who have chronic constipation. About 23 participants will receive either the drug or a placebo for two weeks, then switch after a break. The goal is to see if the dr…

This observational study follows 150,000 people with chronic kidney disease and type 2 diabetes to see how finerenone (Kerendia) works in everyday medical care. Researchers will compare those taking finerenone to those not taking it, looking at rates of heart attacks and heart fa…

This observational study follows over 4,600 adults with chronic kidney disease and type 2 diabetes who are starting finerenone, a drug that helps slow kidney damage. Researchers will collect data from routine doctor visits over 12 months to understand why doctors prescribe it, ho…

This study uses healthcare claims data from nearly 40,000 people to see if the results of a major clinical trial (EMPEROR-Preserved) can be reproduced in a real-world setting. Researchers are comparing two diabetes drugs, empagliflozin and sitagliptin, in patients with heart fail…

This study reviews medical records of 1200 Indian adults with chronic kidney disease and type 2 diabetes who started finerenone between August 2022 and April 2024. Researchers will analyze how doctors prescribed the drug, dose changes, and lab results like kidney function and pot…

This study uses healthcare claims data from nearly 24,000 people to see if it can reproduce the results of the EMPEROR-Reduced trial, which tested the diabetes drug empagliflozin against sitagliptin in heart failure patients. The goal is not to test a new treatment, but to learn …

This study looks at how the liver burns fat and makes sugar in people with NASH (a serious liver disease linked to obesity) who are planning to have weight-loss surgery. Researchers will use special scans to measure liver function before and after surgery in 30 adults. The goal i…

This study checks if a Turkish version of a questionnaire about managing low blood sugar (hypoglycemia) is accurate and reliable. Researchers will ask 200 adults with type 2 diabetes who have had low blood sugar to fill out the questionnaire. The goal is to make sure the scale wo…

This study looks at over 1,200 adults with type 2 diabetes and heart muscle problems to see if diabetic cardiomyopathy is a unique condition. Researchers will use detailed medical tests, imaging, and biological data to find patterns. The goal is to better understand and diagnose …

This study aimed to learn more about using a CT scan to check for calcium buildup in the heart arteries of people with diabetes. The goal was to improve screening and treatment decisions. However, the study was withdrawn before enrolling any participants, so no new information wa…

This study looks at how being overweight and having type 1 or type 2 diabetes may change genetic markers in sperm. Researchers will test if a 3-month lifestyle or blood sugar program can improve these markers. About 40 men will provide sperm samples before and after the program.

This study looks at how the sugars, fats, and proteins in breast milk change from mother to mother and over time. Researchers want to see how these differences, along with the mother's diet and health, affect the development of the baby's gut bacteria. About 395 pregnant women wh…

This study looks at how low blood sugar (hypoglycemia) affects blood vessel function in people with type 2 diabetes and healthy adults. Researchers want to learn if a natural gut hormone called GLP-1 can change these effects. The study involves 28 participants and measures change…

This study looks at whether 6 months of aerobic exercise can improve blood vessel health and cell function in older veterans with impaired glucose tolerance, a pre-diabetic condition. Researchers will measure changes in endothelial progenitor cells and muscle blood flow. The goal…