Can a weekly shot help obese teens avoid diabetes and fatty liver?
NCT ID NCT05067621
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether semaglutide (Wegovy), a once-weekly injection, can preserve the pancreas's ability to produce insulin and reduce liver fat in 60 obese youth with prediabetes or early type 2 diabetes and fatty liver disease. Participants receive either semaglutide or a placebo for 6 months, and researchers measure changes in beta-cell function and liver fat content. The goal is to see if this drug can slow disease progression in this high-risk group.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Semaglutide (Wegovy), a once-weekly injection
- What this could lead to
- If successful, this could point toward a treatment that slows or prevents progression from prediabetes to type 2 diabetes and reduces liver fat in obese youth.
- What could go wrong
- This is an early phase 2 trial with only 60 participants, so results may not apply broadly. The benefits may be modest or not sustained after stopping the drug.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Pediatric Diabetes Center
New Haven, Connecticut, 06511, United States
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