NON-ALCOHOLIC FATTY LIVER DISEASE

This study tests a new medicine called efimosfermin alfa in people with MASH, a liver disease linked to metabolic issues. The goal is to see if the drug is safe and tolerable for patients with moderate liver scarring (stage F2 or F3). About 1,250 adults will receive either the dr…

This study tests a new medicine called efimosfermin alfa in 1200 adults with MASH (a type of fatty liver disease) and moderate-to-severe liver scarring. The goal is to see if the drug can improve scarring and reduce liver inflammation without making the disease worse. Participant…

This study tests whether a medicine called an SGLT2 inhibitor (a type of diabetes drug) can safely reduce liver fat in teenagers with obesity and non-alcoholic fatty liver disease (NAFLD). About 40 teens aged 16 to 21 will receive either the drug or a placebo for 26 weeks. The ma…

This study tests if eating only during an 8-hour window each day, along with a healthy diet and exercise, can reduce liver fat in people with non-alcoholic fatty liver disease. About 40 adults will be assigned to either the time-restricted eating plan or standard lifestyle advice…

This study looks at how the liver responds to eating in people with non-alcoholic fatty liver disease (NAFLD) and whether the drug semaglutide can reduce liver fat and damage. About 84 adults with NAFLD and healthy volunteers will take part. Participants with NAFLD will receive w…

This study tests whether a minimally invasive stomach-shrinking procedure (endoscopic sleeve gastroplasty) combined with lifestyle changes is better than lifestyle changes alone for treating a serious liver condition called MASH in people with obesity. The procedure reduces stoma…

This study tests if carbocisteine, a drug already used for coughs, can safely reduce fat buildup in the liver for people with nonalcoholic fatty liver disease (NAFLD). About 46 adults with fatty liver will take the drug, and doctors will measure changes using ultrasound. The goal…

This study looks at whether a healthy diet and regular walking can improve memory and thinking in people with non-alcoholic fatty liver disease (NAFLD). 45 adults aged 18-42 will be split into three groups: one gets general health advice, another follows a Mediterranean diet, and…

This study tests whether time-restricted intermittent fasting can reduce liver fat in non-obese adults (BMI 23-30) with non-alcoholic fatty liver disease (NAFLD). Researchers will enroll 25 participants to follow a fasting schedule and measure changes in liver fat using MRI. The …

This study aims to improve early diagnosis of liver fibrosis (scarring) by combining standard blood tests with new markers, genetic analysis, and gut bacteria profiles. Researchers will enroll 1,200 adults referred to a liver clinic. The goal is to identify advanced fibrosis soon…

This study aims to find new blood-based markers that can accurately detect liver scarring (fibrosis) in people with fatty liver disease. Currently, the best way to check for scarring is a liver biopsy, which is painful and risky. Researchers will collect blood samples from 575 ad…

This study looks at whether a special ultrasound technique, called endoscopic ultrasound shear wave elastography (EUS-SWE), can better detect liver scarring in people with obesity and fatty liver disease. Standard non-invasive tests are often less accurate in this group. Research…

This study looks at gut bacteria in 3,000 adults with chronic liver diseases like autoimmune hepatitis and fatty liver. Researchers want to find which bacteria are linked to each disease and how they affect disease progression. Participants provide stool samples for analysis, but…

This study aims to understand how insulin controls sugar and fat production in the liver, comparing healthy adults to those at risk for type 2 diabetes. Participants will receive a single dose of the drug alpelisib or a placebo during two overnight hospital stays. Researchers wil…

This early-stage study looks at how a single dose of the experimental drug efimosfermin alfa behaves in the body and whether it is safe for people with different stages of fatty liver disease. About 32 adults with liver cirrhosis will take part. The goal is to gather information,…

This study aims to find genetic and immune system clues that may lead to liver cancer in people with fatty liver disease or alcohol-related liver damage. Researchers will study 710 adults, both with and without cirrhosis, to understand early changes that happen before cancer deve…

This study looks at whether a one-week course of the drug diazoxide can reduce how much fat the liver makes in people with obesity, insulin resistance, and a type of fatty liver disease called MASLD. About 25 adults will take either the drug or a placebo, and researchers will mea…

This early-stage study tests a single dose of efimosfermin alfa in 30 healthy adults of Chinese, Japanese, and White/European ancestry. The goal is to check the drug's safety and how the body processes it. Participants will be monitored for side effects and drug levels in the blo…

This study aims to find out how common non-alcoholic fatty liver disease (NAFLD) and its more serious form, NASH, are in Olmsted County. Researchers will follow 800 adults over time to improve diagnosis and track long-term health issues like liver damage, heart problems, and canc…

This study looks at how liver cells produce energy in people who have both type 2 diabetes and nonalcoholic fatty liver disease. Researchers will measure liver metabolism before and after 16 weeks of treatment with the diabetes drug pioglitazone. The goal is to understand how the…

This study looks at how common fatty liver disease is in children with celiac disease and whether a gluten-free diet helps. Researchers will review medical records of 91 children to track liver health before and after starting the diet. The goal is to better understand the connec…

This study looks at whether people born with a low birth weight have a higher chance of developing non-alcoholic fatty liver disease (NAFLD) as adults. Researchers will compare 250 low-birth-weight adults with 50 normal-birth-weight adults using liver scans and other health tests…

This study collects tissue and blood samples from 800 people with chronic liver disease or liver cancer. Researchers will use these samples to create lab models, such as cell clusters and mouse models, to test new treatments in the future. Participants do not receive any experime…

This study follows 35 people with severe obesity who are having mini-gastric bypass surgery as part of their routine care. Researchers want to see how the surgery helps improve related health problems like type 2 diabetes, sleep apnea, high blood pressure, and fatty liver disease…