NON-ALCOHOLIC FATTY LIVER DISEASE

This study tests whether a daily probiotic lysate supplement can reduce fat and stiffness in the liver of adults with non-alcoholic fatty liver disease (NAFLD). Participants take either the supplement or a placebo for three months, and doctors measure changes using MRI and ultras…

This study tested a new medication called efinopegdutide in 124 adults with fatty liver disease (also called MASLD). The goal was to see if taking the drug every two weeks or every week could safely reduce liver fat. After 28 weeks, the drug helped lower liver fat, and researcher…

This study tested whether a device that measures liver fat at home can motivate people with non-alcoholic fatty liver disease (NAFLD) to stick with diet and exercise. Ten adults with NAFLD used the device and received standard care. The goal was to see if home monitoring leads to…

This study looked at whether changing the amount of methyl donor nutrients (like folate and choline) in the diet could help people with non-alcoholic fatty liver disease (NAFLD). The goal was to reduce liver fat and improve liver function. 51 participants completed the study, and…

This study tested whether ornithine aspartate granules work better than silymarin capsules for non-alcoholic fatty liver disease (NAFLD). 237 adults with NAFLD and elevated liver enzymes took one of the two treatments for a period. The main goal was to see if liver fat levels imp…

This study tested three different probiotics (Pediococcus pentosaceus, Lactobacillus lactis, and Lactobacillus helveticus) in 89 adults with non-alcoholic fatty liver disease. Participants took probiotic capsules or a placebo daily for 8 weeks, along with a standard liver supplem…

This study tested whether a probiotic called L. lactis CKDB001 can improve liver enzyme levels in people with nonalcoholic fatty liver disease (NAFLD). 95 adults with mildly elevated liver enzymes took either the probiotic or a placebo daily for 12 weeks. The goal was to see if t…

This study tested an experimental drug called efinopegdutide in 381 adults with non-alcoholic steatohepatitis (NASH), a serious form of fatty liver disease. The main goal was to see if the drug could help the liver heal (resolve NASH) without making scarring worse. Participants r…

This early-stage trial tested an experimental drug called BI 3006337 in 64 adults who are overweight or obese and have fatty liver disease. Participants received weekly injections of either the drug or a placebo for about 4 months. The main goal was to check safety and tolerabili…

This study tested a drug called tesamorelin in 51 obese adults with nonalcoholic fatty liver disease (NAFLD). The drug is designed to increase growth hormone levels, which may help reduce liver fat and inflammation. Researchers measured changes in liver fat using special scans an…

This study tested a single dose of the experimental drug GSK4532990 in 61 adults with NASH, a type of fatty liver disease. Researchers measured how the drug moves through the body and affects liver proteins, while also checking for safety. The goal is to see if the drug can help …

This study tested whether motivational interviewing, a type of counseling that boosts a person's own desire to change, can help people with non-alcoholic fatty liver disease (NAFLD) lose weight. Over 200 adults with NAFLD and a BMI of 25 or higher took part. Some received four mo…

This study tested whether alternate day fasting (eating only 600 calories on fast days) combined with regular aerobic exercise can reduce liver fat in people with non-alcoholic fatty liver disease (NAFLD). Eighty obese adults aged 18–65 with NAFLD participated. The goal was to se…

This completed trial tested whether drinking Jing-Si Herbal Tea twice daily for 24 weeks can improve markers of non-alcoholic fatty liver disease (NAFLD). 108 adults with moderate NAFLD were randomly assigned to receive the tea or a placebo. Researchers measured changes in blood …

This study tests whether a device called Fibroscan can diagnose fatty liver disease (steatosis) without needing a biopsy. Researchers will measure liver stiffness and viscosity in 72 people, including healthy volunteers and patients with confirmed fatty liver. Results will be com…

This study tested a new ultrasound software that measures liver fat in children and teens aged 5 to 21 with or at risk for fatty liver disease. Researchers compared the ultrasound results to standard MRI scans to see if the ultrasound could accurately detect liver fat. If it work…

This study tested how well a special MRI scan called LiverMultiScan can measure liver fat, iron, and scarring. 61 adults with various liver diseases had up to 6 scans on different machines. The goal was to see if the results are consistent when repeated on the same scanner or on …

This study tested whether a special ultrasound technique can accurately measure liver fat in children with non-alcoholic fatty liver disease (NAFLD). Researchers compared ultrasound results to MRI scans in 90 children aged 6 to 18. If it works, this could offer a faster, radiatio…

This study looked at 180 people with liver cancer (hepatocellular carcinoma) who also had cirrhosis caused by either fatty liver disease or alcohol use. Researchers compared immune cells and gut bacteria in the liver to understand why cancer develops. The goal was to gather knowl…

This completed study observed 40 people with type 2 diabetes to find blood markers that could identify those at risk for a serious liver condition called NASH. Researchers measured liver stiffness and calculated scores like FIB-4 and ELF to see which patients might have liver sca…

This completed study tested different ways to use an ultrasound machine to measure liver fat in 35 healthy adults. The goal was to find the most reliable technique for non-invasively diagnosing fatty liver disease, a common condition linked to obesity and diabetes. By standardizi…

This study tested whether a version of the Mediterranean diet made with Asian ingredients is acceptable to people with non-alcoholic fatty liver disease (NAFLD). 30 participants in Singapore tasted meals from a 4-week menu and rated them. The goal was to see if people liked the f…

This study looked at how consistent FibroScan, a non-invasive device that measures liver stiffness and fat, is when used by different operators on different days. 108 adults with fatty liver or alcohol-related liver disease had multiple scans and blood tests over two visits. The …

This study looked at 38 adults with non-alcoholic fatty liver disease to see if gut bacteria are getting too close to the gut lining, which might worsen liver health. Researchers used a sigmoidoscopy to take tissue samples and measured the distance of microbes from intestinal cel…

This completed study examined immune semaphorin proteins in the liver and fat tissue of 148 obese patients with non-alcoholic fatty liver disease (NAFLD). Researchers aimed to understand how these proteins relate to inflammation and liver damage. The study did not test any treatm…

This completed study looked at whether eating only during a specific daily window (time-restricted eating) can slow the aging process in 176 adults who are overweight or have early fatty liver disease. Participants followed a Mediterranean diet with or without calorie restriction…

This study looked at whether fatty liver disease can be an early warning sign for heart disease, separate from known risk factors. Researchers measured blood markers of blood vessel damage in 63 people aged 50-69 who were already at high risk for heart problems. The goal was to b…

This study examined medical records of 263 adults with NASH to see how factors like age, other health problems, and medications relate to the severity of liver scarring. The goal was to identify which patients are at higher risk for advanced fibrosis. The findings may help doctor…

This study tested a new ultrasound feature that measures liver fat and compared it to the standard MRI method. About 60 adults with or at risk for fatty liver disease had two ultrasounds and one MRI. The goal was to see if the ultrasound could accurately estimate liver fat, which…

This completed Phase 1 study from Columbia University enrolled 18 overweight or obese adults with insulin resistance and non-alcoholic fatty liver disease (NAFLD). Researchers used a technique called a pancreatic clamp to carefully control insulin levels and measure how blood sug…

This study tested whether a drug called diazoxide, which lowers high insulin levels, can help researchers understand how fatty liver disease develops. Twenty-four adults with overweight or obesity and insulin resistance took either a low or high dose of diazoxide or a placebo for…

This study looked at 1,000 people aged 40-80 with type 2 diabetes or obesity to find the best way to screen for advanced liver scarring (fibrosis) from fatty liver disease. Researchers tested combinations of blood tests and a special ultrasound (FibroScan) to see which approach m…

This study looked at 67 adults with type 2 diabetes and fatty liver disease who were starting a type of diabetes medication called SGLT2 inhibitors. Researchers used ultrasound and blood tests to measure changes in liver stiffness and fat after 6 months of treatment. The goal was…

This completed study looked at the economic burden of non-alcoholic fatty liver disease (NAFLD) in 73 adults in Flanders, Belgium. Researchers measured healthcare costs, patient expenses, and quality of life using questionnaires. The goal was to understand the financial impact of…

This study tested whether a personalized lifestyle program could be run in a family medicine clinic for people with insulin resistance and related conditions like obesity, diabetes, and high blood pressure. Forty participants were randomly assigned to start with either nutrition …