Gut microbes linked to fatty liver – new study explores connection

NCT ID NCT05209100

Completed Knowledge-focused Sponsor: AdventHealth Translational Research Institute Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at 38 adults with non-alcoholic fatty liver disease to see if gut bacteria are getting too close to the gut lining, which might worsen liver health. Researchers used a sigmoidoscopy to take tissue samples and measured the distance of microbes from intestinal cells. The goal was to gather first human evidence on this 'microbiome encroachment' and create a biobank for future research.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could reveal how gut bacteria contribute to fatty liver disease, pointing toward new ways to diagnose or treat it.
What could go wrong: This is a small, early observational study with only 38 participants. It does not test any treatment, so results may not lead directly to therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for NON-ALCOHOLIC FATTY LIVER DISEASE are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

fatty liver disease Fibrosis metabolic dysfunction-associated steatotic liver disease Obesity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-ALCOHOLIC FATTY LIVER DISEASE

Contacts and locations

Locations

AdventHealth Translational Research Institute

Orlando, Florida, 32804, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.