Tiny study probes Insulin's role in fatty liver – could it lead to new treatments?
NCT ID NCT05724134
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed Phase 1 study from Columbia University enrolled 18 overweight or obese adults with insulin resistance and non-alcoholic fatty liver disease (NAFLD). Researchers used a technique called a pancreatic clamp to carefully control insulin levels and measure how blood sugar responds. The goal was to understand the link between high insulin and NAFLD, not to test a new treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Insulin, Octreotide, Glucagon
- What this could lead to
- If successful, this could help researchers understand the role of high insulin in fatty liver disease, potentially pointing toward new treatment strategies.
- What could go wrong
- This is a very small, early-phase feasibility study (18 people) designed to test a procedure, not to treat disease. Results may not apply to broader populations.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Columbia University Irving Medical Center
New York, New York, 10032, United States
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