Could a probiotic supplement help reverse fatty liver?

NCT ID NCT05804422

Completed Disease control Sponsor: Bogomolets National Medical University Source: ClinicalTrials.gov ↗

First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time

Summary

This study tests whether a daily probiotic lysate supplement can reduce fat and stiffness in the liver of adults with non-alcoholic fatty liver disease (NAFLD). Participants take either the supplement or a placebo for three months, and doctors measure changes using MRI and ultrasound. The goal is to see if this simple, over-the-counter-style approach can improve liver health without major side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Probiotic lysate (postbiotic and metabiotic) from L. rhamnosus DV
What this could lead to: If effective, this supplement could offer a simple, safe way to reduce liver fat and improve liver health in people with NAFLD.
What could go wrong: This is a small, short-term study with only 39 participants. Results may not apply to everyone, and the supplement may not outperform placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

fatty liver disease metabolic dysfunction-associated steatotic liver disease Obesity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FATTY LIVER HEPATIC STEATOSIS NON ALCOHOLIC FATTY LIVER NON-ALCOHOLIC FATTY LIVER DISEASE

Contacts and locations

Locations

Bogomolets National Medical University

Kyiv, 01601, Ukraine
Center for Innovative Medical Technologies of the National Academy of Sciences of Ukraine

Kyiv, 02000, Ukraine
Danylo Halytsky Lviv National Medical University

Lviv, 79010, Ukraine
Kyiv City Clinical Endocrinology Center

Kyiv, 01601, Ukraine

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