NON-ALCOHOLIC FATTY LIVER DISEASE

This study looks at how the liver responds to food and a drug called semaglutide in people with non-alcoholic fatty liver disease (NAFLD). About 84 adults, including healthy volunteers, will take part. Researchers will check if semaglutide can reduce liver fat and damage over 30 …

This study tests whether a minimally invasive procedure called endoscopic sleeve gastroplasty (ESG), which reduces stomach size by 70%, can help reverse fatty liver disease (MASH) in people with obesity. Researchers will compare ESG plus lifestyle changes to lifestyle changes alo…

This study tests whether adding a physical activity program to standard care can improve health in older women who have three conditions: underactive thyroid (hypothyroidism), glaucoma (high pressure in the eyes), and fatty liver. Researchers will measure changes in eye pressure,…

This study tests whether carbocisteine, a drug already used for coughs, can safely reduce fat buildup in the liver of people with nonalcoholic fatty liver disease (NAFLD). About 46 adults with fatty liver will take the drug and be monitored for changes in liver fat via ultrasound…

This phase 3 trial tests a drug called efimosfermin alfa in 1250 adults with MASH (a fatty liver disease) and moderate liver scarring. The main goal is to check safety and side effects. Participants will receive either the drug or a placebo, and researchers will monitor liver hea…

This Phase 3 trial tests whether efimosfermin alfa can improve liver scarring and reduce inflammation in people with MASH (a type of fatty liver disease). About 1,200 adults with moderate-to-severe liver fibrosis will receive the drug or a placebo for 52 weeks. The goal is to see…

This study tests if eating only during an 8-hour window each day, along with a healthy diet and exercise, can reduce liver fat in people with non-alcoholic fatty liver disease. About 40 adults will be split into two groups: one follows the time-restricted eating plan plus standar…

This Phase 3 trial tests a drug called LAENNEC, made from human placenta, in people with chronic liver disease. It compares giving the drug as an intravenous drip versus a standard shot under the skin. The main goal is to see if the IV form lowers liver enzyme levels more effecti…

This study tests whether empagliflozin (Jardiance), a drug used for diabetes, can reduce liver fat in teenagers with obesity and non-alcoholic fatty liver disease (NAFLD). Forty participants aged 16 to under 21 will receive either the drug or a placebo for 26 weeks. The main goal…

This study looks at whether the diabetes drug pioglitazone can improve how the liver processes energy in people with nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes. Researchers will measure liver mitochondrial function using special tracers before and after 16 weeks…

This study tests whether a Mediterranean diet and regular walking can improve memory and thinking in adults with non-alcoholic fatty liver disease (NAFLD). 45 participants aged 18-42 will be split into three groups: general health advice, a structured Mediterranean diet, or the d…

This pilot study tests whether time-restricted intermittent fasting can lower liver fat in non-obese adults (BMI 23-30) with non-alcoholic fatty liver disease (NAFLD). Researchers will measure liver fat changes using advanced imaging and track quality of life. The goal is to find…

This study is collecting blood samples from 575 adults with fatty liver disease to find new, noninvasive tests that can detect liver scarring (fibrosis). Currently, doctors rely on a painful liver biopsy to check for scarring, but this research aims to replace that with a simple …

This study tests whether a special ultrasound done during an endoscopy can accurately detect liver scarring in people with obesity and suspected non-alcoholic fatty liver disease. Researchers will compare this new method to standard tests and liver biopsy in 150 adults. The proce…

This study is testing whether combining new blood tests and stool analysis can detect liver fibrosis earlier than current methods. Researchers will follow 1200 adults referred to a community liver clinic. The goal is to identify advanced liver disease sooner and reduce unnecessar…

This study looks at 20 adults with psoriatic arthritis and fatty liver disease to see if the drug guselkumab can improve liver fat, joint swelling, and skin plaques. Participants will have two visits over 24 weeks to track changes. The goal is to understand shared disease mechani…

This study looks at whether people born with a low birth weight have a higher chance of developing non-alcoholic fatty liver disease (NAFLD) as adults. Researchers will compare 250 low-birth-weight adults with 50 normal-birth-weight adults using liver scans and other tests. The g…

This early-stage study tests a single dose of an experimental drug called efimosfermin alfa in 32 adults with fatty liver disease and varying degrees of liver damage. The goal is to see how the drug moves through the body and whether it is safe. Participants must have liver cirrh…

This study compares people with non-alcoholic fatty liver disease (NAFLD) to healthy controls to understand how the immune system, metabolism, and gut bacteria differ. Researchers will also track what happens to liver health in NAFLD patients who undergo weight loss surgery. The …

This study looks at how often children with celiac disease also have fatty liver disease, and whether a gluten-free diet helps. Researchers will review medical records of 91 children to track changes before and after starting the diet. The goal is to better understand the link be…

This study is recruiting 710 adults with fatty liver disease or alcohol-related liver disease, with or without cirrhosis, to understand why some develop liver cancer. Researchers will analyze genetic markers, immune factors, and imaging data from routine liver biopsies and blood …

This early-stage trial is testing whether a one-week course of diazoxide can reduce the production of new fat in the liver. The study involves 25 adults with obesity, insulin resistance, and fatty liver disease. Participants will take either the drug or a placebo and undergo bloo…

This study looks at how the hormone insulin controls blood sugar and fat in healthy adults and those at risk for type 2 diabetes. Researchers will give participants a single dose of a drug called alpelisib, which blocks some of insulin's effects, to see if the liver can still mak…

This early-stage study tests a single dose of the experimental drug efimosfermin alfa in 30 healthy adults of Chinese, Japanese, and White/European ancestry. The goal is to check safety, how the body processes the drug, and immune reactions. Participants will not receive any trea…

This study looks at the gut bacteria of 3000 adults with chronic liver diseases like autoimmune hepatitis and fatty liver. Researchers want to find specific bacteria linked to each disease to better understand how the gut and liver interact. This is an observational study, not a …

This study follows 35 people with severe obesity who are having mini-gastric bypass surgery. Researchers want to see how the surgery changes body composition and improves related health issues like type 2 diabetes, sleep apnea, high blood pressure, and fatty liver disease. The go…

This study collects blood and tissue samples from 800 people with chronic liver disease or liver cancer. Researchers will use these samples to create lab models, such as cell clusters and mouse tumors, to study these diseases and test new treatments. The goal is to improve unders…

This study looks at how common non-alcoholic fatty liver disease (NAFLD) and its more serious form, NASH, are in Olmsted County, Minnesota. Researchers will follow 800 adults over time to better diagnose these conditions and see how they affect long-term health, including risks f…

This study looks at 1,000 people with alcohol-related liver disease to understand how their genes and drinking habits together raise the risk of liver cancer. Researchers will analyze DNA and lifestyle factors to create a risk score that could help doctors decide who needs regula…