New drug aims to reverse liver damage in MASH patients
NCT ID NCT07221227
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 3 trial tests whether efimosfermin alfa can improve liver scarring and reduce inflammation in people with MASH (a type of fatty liver disease). About 1,200 adults with moderate-to-severe liver fibrosis will receive the drug or a placebo for 52 weeks. The goal is to see if the drug can reverse liver damage and prevent serious liver complications.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
efimosfermin alfa
What this could lead to
If successful, this drug could become a treatment that reverses liver scarring and prevents liver failure in people with MASH.
What could go wrong
This is a large Phase 3 trial, but the drug is still experimental. It may not work better than placebo, and side effects are possible. Results are expected after 52 weeks.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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GSK Investigational Site
RECRUITINGArcadia, California, 91006, United States
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GSK Investigational Site
RECRUITINGCovina, California, 91723, United States
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GSK Investigational Site
RECRUITINGLos Angeles, California, 90057, United States
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GSK Investigational Site
RECRUITINGSanta Maria, California, 93458, United States
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GSK Investigational Site
RECRUITINGVan Nuys, California, 91405, United States
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GSK Investigational Site
RECRUITINGBoynton Beach, Florida, 33435, United States
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GSK Investigational Site
RECRUITINGCape Coral, Florida, 33914, United States
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GSK Investigational Site
RECRUITINGHialeah, Florida, 33016, United States
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GSK Investigational Site
RECRUITINGHialeah, Florida, 33016, United States
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GSK Investigational Site
RECRUITINGInverness, Florida, 34452, United States
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GSK Investigational Site
RECRUITINGJacksonville, Florida, 32216, United States
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GSK Investigational Site
RECRUITINGKissimmee, Florida, 34744, United States
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GSK Investigational Site
RECRUITINGLakeland, Florida, 33803, United States
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GSK Investigational Site
RECRUITINGMaitland, Florida, 32751, United States
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GSK Investigational Site
RECRUITINGMiami, Florida, 33135, United States
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GSK Investigational Site
RECRUITINGMiami, Florida, 33144, United States
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GSK Investigational Site
RECRUITINGMiami, Florida, 33155, United States
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GSK Investigational Site
RECRUITINGMiami, Florida, 33156, United States
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GSK Investigational Site
RECRUITINGMiami, Florida, 33184, United States
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GSK Investigational Site
RECRUITINGMiami Lakes, Florida, 33014, United States
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GSK Investigational Site
RECRUITINGOcala, Florida, 34471, United States
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GSK Investigational Site
RECRUITINGPalmetto Bay, Florida, 33157, United States
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GSK Investigational Site
RECRUITINGTopeka, Kansas, 66606, United States
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GSK Investigational Site
RECRUITINGSpringfield, Missouri, 62703, United States
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GSK Investigational Site
RECRUITINGSt Louis, Missouri, 63141, United States
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GSK Investigational Site
RECRUITINGEast Syracuse, New York, 13057, United States
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GSK Investigational Site
RECRUITINGNew York, New York, 10036, United States
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GSK Investigational Site
RECRUITINGNew York, New York, 10036, United States
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GSK Investigational Site
RECRUITINGMorehead City, North Carolina, 28557, United States
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GSK Investigational Site
RECRUITINGAkron, Ohio, 44320, United States
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GSK Investigational Site
RECRUITINGSpringboro, Ohio, 45066, United States
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GSK Investigational Site
RECRUITINGChattanooga, Tennessee, 37421, United States
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GSK Investigational Site
RECRUITINGAustin, Texas, 78704, United States
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GSK Investigational Site
RECRUITINGAustin, Texas, 78759, United States
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GSK Investigational Site
RECRUITINGBellaire, Texas, 77401, United States
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GSK Investigational Site
RECRUITINGBrownsville, Texas, 78526, United States
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GSK Investigational Site
RECRUITINGDallas, Texas, 75243, United States
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GSK Investigational Site
RECRUITINGDeSoto, Texas, 75115, United States
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GSK Investigational Site
RECRUITINGRichmond, Texas, 77406, United States
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GSK Investigational Site
RECRUITINGSan Antonio, Texas, 78215, United States
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GSK Investigational Site
RECRUITINGSan Antonio, Texas, 78229, United States
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GSK Investigational Site
RECRUITINGSeabrook, Texas, 77586, United States
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GSK Investigational Site
RECRUITINGSugar Land, Texas, 77479, United States
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GSK Investigational Site
RECRUITINGTomball, Texas, 77375, United States
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GSK Investigational Site
RECRUITINGWaco, Texas, 76710, United States
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GSK Investigational Site
RECRUITINGWaco, Texas, 76712, United States
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GSK Investigational Site
RECRUITINGWest Jordan, Utah, 84088, United States
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GSK Investigational Site
RECRUITINGManassas, Virginia, 20110, United States
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GSK Investigational Site
RECRUITINGSeattle, Washington, 98105, United States
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