New drug aims to reverse liver damage in MASH patients

NCT ID NCT07221227

Recruiting now Disease control Sponsor: GlaxoSmithKline Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 28, 2026 · Updated 2 times

Summary

This Phase 3 trial tests whether efimosfermin alfa can improve liver scarring and reduce inflammation in people with MASH (a type of fatty liver disease). About 1,200 adults with moderate-to-severe liver fibrosis will receive the drug or a placebo for 52 weeks. The goal is to see if the drug can reverse liver damage and prevent serious liver complications.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: efimosfermin alfa
What this could lead to: If successful, this drug could become a treatment that reverses liver scarring and prevents liver failure in people with MASH.
What could go wrong: This is a large Phase 3 trial, but the drug is still experimental. It may not work better than placebo, and side effects are possible. Results are expected after 52 weeks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for METABOLIC DYSFUNCTION-ASSOCIATED STEATOHEPATITIS WITH STAGE F2 OR F3 FIBROSIS are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

metabolic dysfunction-associated steatohepatitis metabolic dysfunction-associated steatotic liver disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-ALCOHOLIC FATTY LIVER DISEASE

Contacts and locations

Locations

GSK Investigational Site
RECRUITING

Chandler, Arizona, 85224, United States
GSK Investigational Site
RECRUITING

Tucson, Arizona, 85712, United States
GSK Investigational Site
RECRUITING

Little Rock, Arkansas, 72211, United States
GSK Investigational Site
RECRUITING

Arcadia, California, 91006, United States
GSK Investigational Site
RECRUITING

Covina, California, 91723, United States
GSK Investigational Site
RECRUITING

Folsom, California, 95630, United States
GSK Investigational Site
RECRUITING

Los Angeles, California, 90057, United States
GSK Investigational Site
RECRUITING

Montclair, California, 91763, United States
GSK Investigational Site
RECRUITING

Riverdale, California, 30274, United States
GSK Investigational Site
RECRUITING

San Diego, California, 92120, United States
GSK Investigational Site
RECRUITING

Santa Maria, California, 93458, United States
GSK Investigational Site
RECRUITING

Van Nuys, California, 91405, United States
GSK Investigational Site
RECRUITING

Colorado Springs, Colorado, 80907, United States
GSK Investigational Site
RECRUITING

Boynton Beach, Florida, 33435, United States
GSK Investigational Site
RECRUITING

Cape Coral, Florida, 33914, United States
GSK Investigational Site
RECRUITING

Clermont, Florida, 34711, United States
GSK Investigational Site
RECRUITING

Fort Myers, Florida, 33912, United States
GSK Investigational Site
RECRUITING

Hialeah, Florida, 33016, United States
GSK Investigational Site
RECRUITING

Hialeah, Florida, 33016, United States
GSK Investigational Site
RECRUITING

Homestead, Florida, 33033, United States
GSK Investigational Site
RECRUITING

Inverness, Florida, 34452, United States
GSK Investigational Site
RECRUITING

Jacksonville, Florida, 32216, United States
GSK Investigational Site
RECRUITING

Kissimmee, Florida, 34744, United States
GSK Investigational Site
RECRUITING

Lakeland, Florida, 33803, United States
GSK Investigational Site
RECRUITING

Maitland, Florida, 32751, United States
GSK Investigational Site
RECRUITING

Miami, Florida, 33135, United States
GSK Investigational Site
RECRUITING

Miami, Florida, 33144, United States
GSK Investigational Site
RECRUITING

Miami, Florida, 33155, United States
GSK Investigational Site
RECRUITING

Miami, Florida, 33156, United States
GSK Investigational Site
RECRUITING

Miami, Florida, 33173, United States
GSK Investigational Site
RECRUITING

Miami, Florida, 33176, United States
GSK Investigational Site
RECRUITING

Miami, Florida, 33184, United States
GSK Investigational Site
RECRUITING

Miami Lakes, Florida, 33014, United States
GSK Investigational Site
RECRUITING

Ocala, Florida, 34471, United States
GSK Investigational Site
RECRUITING

Palmetto Bay, Florida, 33157, United States
GSK Investigational Site
RECRUITING

Sarasota, Florida, 34201, United States
GSK Investigational Site
RECRUITING

Marietta, Georgia, 30060, United States
GSK Investigational Site
RECRUITING

Topeka, Kansas, 66606, United States
GSK Investigational Site
RECRUITING

Bastrop, Louisiana, 71220, United States
GSK Investigational Site
RECRUITING

Marrero, Louisiana, 70072, United States
GSK Investigational Site
RECRUITING

Kansas City, Missouri, 64131, United States
GSK Investigational Site
RECRUITING

Springfield, Missouri, 62703, United States
GSK Investigational Site
RECRUITING

St Louis, Missouri, 63141, United States
GSK Investigational Site
RECRUITING

Las Vegas, Nevada, 89106, United States
GSK Investigational Site
RECRUITING

East Syracuse, New York, 13057, United States
GSK Investigational Site
RECRUITING

New York, New York, 10036, United States
GSK Investigational Site
RECRUITING

New York, New York, 10036, United States
GSK Investigational Site
RECRUITING

Fayetteville, North Carolina, 28304, United States
GSK Investigational Site
RECRUITING

Morehead City, North Carolina, 28557, United States
GSK Investigational Site
RECRUITING

Akron, Ohio, 44320, United States
GSK Investigational Site
RECRUITING

Springboro, Ohio, 45066, United States
GSK Investigational Site
RECRUITING

Westlake, Ohio, 44145, United States
GSK Investigational Site
RECRUITING

Chattanooga, Tennessee, 37421, United States
GSK Investigational Site
RECRUITING

Arlington, Texas, 76012, United States
GSK Investigational Site
RECRUITING

Austin, Texas, 78704, United States
GSK Investigational Site
RECRUITING

Austin, Texas, 78757, United States
GSK Investigational Site
RECRUITING

Austin, Texas, 78759, United States
GSK Investigational Site
RECRUITING

Bellaire, Texas, 77401, United States
GSK Investigational Site
RECRUITING

Brownsville, Texas, 78526, United States
GSK Investigational Site
RECRUITING

Dallas, Texas, 75243, United States
GSK Investigational Site
RECRUITING

DeSoto, Texas, 75115, United States
GSK Investigational Site
RECRUITING

Houston, Texas, 77004, United States
GSK Investigational Site
RECRUITING

Irving, Texas, 75061, United States
GSK Investigational Site
RECRUITING

Richmond, Texas, 77406, United States
GSK Investigational Site
RECRUITING

San Antonio, Texas, 78209, United States
GSK Investigational Site
RECRUITING

San Antonio, Texas, 78215, United States
GSK Investigational Site
RECRUITING

San Antonio, Texas, 78229, United States
GSK Investigational Site
RECRUITING

Seabrook, Texas, 77586, United States
GSK Investigational Site
RECRUITING

Sugar Land, Texas, 77479, United States
GSK Investigational Site
RECRUITING

Tomball, Texas, 77375, United States
GSK Investigational Site
RECRUITING

Waco, Texas, 76710, United States
GSK Investigational Site
RECRUITING

Waco, Texas, 76712, United States
GSK Investigational Site
RECRUITING

West Jordan, Utah, 84088, United States
GSK Investigational Site
RECRUITING

Manassas, Virginia, 20110, United States
GSK Investigational Site
RECRUITING

Norfolk, Virginia, 23502, United States
GSK Investigational Site
RECRUITING

Seattle, Washington, 98105, United States
GSK Investigational Site
RECRUITING

Broadmeadow, New South Wales, 2292, Australia
GSK Investigational Site
RECRUITING

Heidelberg, Victoria, 3084, Australia
GSK Investigational Site
RECRUITING

Québec, Quebec, G1N 4V3, Canada
GSK Investigational Site
RECRUITING

Pokfulam, Hong Kong
GSK Investigational Site
RECRUITING

Gifu, 503-8502, Japan
GSK Investigational Site
RECRUITING

Kanagawa, 215-0026, Japan
GSK Investigational Site
RECRUITING

Kyoto, 602-8566, Japan
GSK Investigational Site
RECRUITING

Musashino, 180-8610, Japan
GSK Investigational Site
RECRUITING

Yokohama, 236-0004, Japan
GSK Investigational Site
RECRUITING

Wellington, 6021, New Zealand
GSK Investigational Site
RECRUITING

San Juan, 00927, Puerto Rico
GSK Investigational Site
RECRUITING

Riyadh, 11472, Saudi Arabia
GSK Investigational Site
RECRUITING

Chiayi City, 600, Taiwan
GSK Investigational Site
RECRUITING

Kaohsiung City, 80756, Taiwan
GSK Investigational Site
RECRUITING

Kaohsiung City, 83301, Taiwan

More trials for these conditions

Other studies related to the condition(s) this trial covers.