Electric pulses to the gut could help control early diabetes without drugs
NCT ID NCT07376486
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tests a procedure called pulsENDO that uses mild electric pulses to regenerate the lining of the first part of the small intestine (duodenum) in people recently diagnosed with type 2 diabetes. The goal is to see if this can help control blood sugar levels without needing diabetes medications. The trial will enroll 40 participants and follow them for up to 24 months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- pulsENDO procedure (non-thermal pulsed electric field applied to the duodenum via endoscopy)
- What this could lead to
- If it works, this could offer a drug-free way to control blood sugar in early type 2 diabetes, potentially reducing or eliminating the need for daily medication.
- What could go wrong
- This is a very early, small trial (40 people) with no control group, so results may not be generalizable. The procedure carries risks from endoscopy and the electric pulses, and long-term safety and effectiveness are unknown.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Chinese University of Hong Kong
Shatin, Hong Kong
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