Could a diabetes drug before bariatric surgery supercharge weight loss?
NCT ID NCT07622992
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study will compare three approaches before gastric bypass surgery for severe obesity: taking the medication tirzepatide for 60 days, following a ketogenic diet for 4 weeks, or receiving standard care. The goal is to see which method leads to the most weight loss one year after surgery. The trial will also track safety and improvements in related health issues like diabetes and high blood pressure.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- tirzepatide
- What this could lead to
- If successful, this could show that a short course of tirzepatide before surgery leads to greater weight loss and better control of obesity-related conditions like diabetes and high blood pressure.
- What could go wrong
- This is a small, early-stage study with only 96 participants, so results may not apply to everyone. The benefits of tirzepatide may not persist long-term, and the drug can cause side effects like nausea or vomiting.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University Federico II of Naples
Naples, Italy, 80131, Italy
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