Can a cholesterol-lowering combo also shrink fatty liver in diabetic heart patients?
NCT ID NCT07736313
First seen Jul 30, 2026 · Last updated Jul 31, 2026 · Updated 1 time
Summary
This trial investigates whether adding a PCSK9 inhibitor to a high-intensity statin can reduce liver fat—measured by a non-invasive FibroScan—in diabetic patients who have recently had a heart attack or unstable angina. Half the participants will receive the combination therapy, while the other half receive the statin alone. The goal is to see if the combination offers additional benefits for liver health and cholesterol control.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- a PCSK9 inhibitor (a cholesterol-lowering drug) plus rosuvastatin 20 mg tablet
- What this could lead to
- If it works, this could point toward a way to both lower cholesterol and reduce liver fat in diabetic heart patients, potentially lowering their risk of future heart problems.
- What could go wrong
- This is a small, early-phase trial (120 people) focused on a liver fat measurement, not on actual heart events. The added benefit over statins alone may be modest, and PCSK9 inhibitors can cause injection-site reactions or muscle pain.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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