Exercise plus supplement may boost muscle and blood sugar in older diabetics

NCT ID NCT07142941

Not yet recruiting Disease control Sponsor: Wu Shangling Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a supplement called HMB, combined with exercise, can improve muscle mass, strength, and insulin resistance in older adults (ages 60-80) with type 2 diabetes and low muscle mass. Participants will be randomly assigned to receive HMB, exercise, both, or placebo/education alone for several weeks. The goal is to find the best way to help this group stay stronger and healthier.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: HMB (beta-hydroxy-beta-methylbutyrate) dietary supplement and supervised exercise
What this could lead to: If successful, this could point toward a practical, non-drug way to help older adults with diabetes maintain muscle and improve blood sugar control.
What could go wrong: This is a relatively small, early-stage trial with 120 participants. The benefits may be modest, and results may not apply to all older adults with diabetes.

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Conditions

The condition(s) this trial relates to.

diabetes mellitus Motor Activity type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETES LOW MUSCLE MASS

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Other studies related to the condition(s) this trial covers.