Talking therapy may lower diabetes risk in depressed teen girls

NCT ID NCT03263351

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study looked at whether a type of talk therapy (cognitive-behavioral therapy) could improve how the body uses insulin in teenage girls at risk for type 2 diabetes. The 147 participants were girls aged 12-17 with depressive symptoms and a family history of diabetes. The therapy group was compared to a health education group over one year to see changes in insulin sensitivity and depression.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
cognitive-behavioral therapy
What this could lead to
If successful, this approach could offer a non-drug way to reduce diabetes risk in teens with depression.
What could go wrong
This is a small, early-stage study with 147 participants, and results may not apply to all groups. The therapy may not improve insulin sensitivity as hoped.

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder Insulin Resistance Pediatric Obesity type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Children's Hospital Colorado

    Aurora, Colorado, 80045, United States

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