Heart's energy use revealed by new MRI technique in early trial

NCT ID NCT02648009

Recruiting now Knowledge-focused Sponsor: Sunnybrook Health Sciences Centre Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase study tests a new MRI method that uses a special injection called hyperpolarized pyruvate to see how the heart uses energy. Researchers will scan the hearts of up to 112 people with high blood pressure, heart thickening, or heart failure. The goal is to see if this technique can show metabolic activity, which might help doctors better understand and manage heart conditions.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Hyperpolarized Pyruvate (13C) Injection
What this could lead to: If successful, this imaging technique could help doctors see how the heart uses energy, potentially leading to better diagnosis and treatment of heart failure.
What could go wrong: This is a very early Phase 1 study focused on imaging, not treatment. It may not lead to any direct patient benefit, and the new method might not work as hoped in larger groups.

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Conditions

The condition(s) this trial relates to.

heart failure hypertensive disorder hypertrophic cardiomyopathy Hypertrophy type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPERTENSION HYPERTROPHY

Contacts and locations

Locations

St. Michael's Hospital
NOT_YET_RECRUITING

Toronto, Ontario, Canada
Sunnybrook Health Sciences Centre
RECRUITING

Toronto, Ontario, M4N 3M5, Canada

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