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New obesity drug ARO-INHBE enters human trials

NCT ID NCT06700538

Recruiting now Disease control Sponsor: Arrowhead Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests an experimental drug called ARO-INHBE in 180 adults with obesity, some of whom also have type 2 diabetes. The drug is given as a shot under the skin, either alone or combined with the existing weight-loss drug tirzepatide. The main goal is to check safety and how the body processes the drug, while also looking at weight changes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
ARO-INHBE (an experimental drug given as a shot under the skin)
What this could lead to
If successful, this could lead to a new weight-loss treatment that works alone or alongside existing drugs like tirzepatide.
What could go wrong
This is an early-phase trial with only 180 participants, so safety and effectiveness are not yet proven. The drug may cause side effects or fail to show meaningful weight loss.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY

Contacts and locations

Locations

  • Research Site 1

    RECRUITING

    Grafton, Auckland, 1010, New Zealand

  • Research Site 2

    RECRUITING

    Christchurch, 8011, New Zealand

  • Research Site 3

    RECRUITING

    Auckland, 2025, New Zealand

  • Research Site 4

    RECRUITING

    Hamilton, 3216, New Zealand

  • Research Site 5

    RECRUITING

    Auckland, 0632, New Zealand

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