New weekly shot could help millions shed pounds and control diabetes

NCT ID NCT07284901

Recruiting now Disease control Sponsor: Kailera Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 16, 2026 · Updated 2 times

Summary

This Phase 3 trial tests a new drug called KAI-9531, given as a weekly injection, in 1700 adults who are overweight or obese and have type 2 diabetes. The study compares KAI-9531 to a placebo to see if it leads to greater weight loss and better blood sugar control over 76 weeks. Participants must have tried and failed to lose weight before.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: KAI-9531
What this could lead to: If successful, this could offer a new once-weekly injection to help people with obesity and diabetes lose weight and improve blood sugar control.
What could go wrong: This is a large Phase 3 trial, but the drug is still experimental. It may not prove superior to placebo, and side effects are possible. Results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

diabetes mellitus Obesity obesity disorder Overweight type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY WITH DIABETES OVERWEIGHT WITH DIABETES

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Kailera Clinical Site
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Cullman, Alabama, 35055, United States
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Phoenix, Arizona, 85012, United States
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Sun City, Arizona, 85351, United States
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Little Rock, Arkansas, 72205, United States
Kailera Clinical Site
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Escondido, California, 92025, United States
Kailera Clinical Site
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Montclair, California, 91763, United States
Kailera Clinical Site
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Northridge, California, 91325, United States
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Oceanside, California, 92058, United States
Kailera Clinical Site
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Toluca Lake, California, 91602, United States
Kailera Clinical Site
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Stamford, Connecticut, 06905, United States
Kailera Clinical Site
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Jupiter, Florida, 33458, United States
Kailera Clinical Site
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Miami, Florida, 33135, United States
Kailera Clinical Site
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Orange City, Florida, 32763, United States
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Orlando, Florida, 32801, United States
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Orlando, Florida, 32803, United States
Kailera Clinical Site
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The Villages, Florida, 32162, United States
Kailera Clinical Site
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Lilburn, Georgia, 30047, United States
Kailera Clinical Site
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Skokie, Illinois, 60077, United States
Kailera Clinical Site
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Springfield, Illinois, 62702, United States
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Newton, Kansas, 67114, United States
Kailera Clinical Site
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Shreveport, Louisiana, 71105, United States
Kailera Clinical Site
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Columbia, Maryland, 21045, United States
Kailera Clinical Site
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Farmington Hills, Michigan, 48334, United States
Kailera Clinical Site
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Missoula, Montana, 59804, United States
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Lincoln, Nebraska, 68516, United States
Kailera Clinical Site
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Las Vegas, Nevada, 89148, United States
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Albany, New York, 12203, United States
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Laurelton, New York, 11413, United States
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Greensboro, North Carolina, 27405, United States
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Morehead City, North Carolina, 28557, United States
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Chickasha, Oklahoma, 73018, United States
Kailera Clinical Site
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Spartanburg, South Carolina, 29303, United States
Kailera Clinical Site
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Chattanooga, Tennessee, 37405, United States
Kailera Clinical Site
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Amarillo, Texas, 79124, United States
Kailera Clinical Site
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Brownsville, Texas, 78526, United States
Kailera Clinical Site
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DeSoto, Texas, 75115, United States
Kailera Clinical Site
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Tomball, Texas, 77375, United States
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Pleasant View, Utah, 84404, United States
Kailera Clinical Site
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Salt Lake City, Utah, 84117, United States
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Manassas, Virginia, 20110, United States
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Richmond, Virginia, 23236, United States
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Ciudad Autonoma de Buenos Aires, Buenos Aires, 1120, Argentina
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Mar del Plata, Buenos Aires, 7600, Argentina
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San Nicolás de los Arroyos, Buenos Aires, 2900, Argentina
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Zárate, Buenos Aires, 2800, Argentina
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Buenos Aires, Buenos Aires F.D., 1060, Argentina
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Godoy Cruz, Mendoza Province, 5501, Argentina
Kailera Clinical Site
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Rosario, Sante Fe, 2000, Argentina
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CABA, 1061, Argentina
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Córdoba, 5002, Argentina
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Bruce, Australian Capital Territory, 2617, Australia
Kailera Clinical Site
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Blacktown, New South Wales, 2148, Australia
Kailera Clinical Site
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Kanwal, New South Wales, 2259, Australia
Kailera Clinical Site
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Leichhardt, New South Wales, 2040, Australia
Kailera Clinical Site
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Sydney, New South Wales, 2100, Australia
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Sydney, New South Wales, 2228, Australia
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Wollongong, New South Wales, 2500, Australia
Kailera Clinical Site
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Herston, Queensland, 4006, Australia
Kailera Clinical Site
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Morayfield, Queensland, 4506, Australia
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Camberwell, Victoria, 3124, Australia
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Melbourne, Victoria, 3025, Australia
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South Brisbane, 4101, Australia
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Kyustendil, Kyustendil Province, 2500, Bulgaria
Kailera Clinical Site
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Pleven, Pleven Province, 5800, Bulgaria
Kailera Clinical Site
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Plovdiv, Plovdiv Province, 4020, Bulgaria
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Rousse, Ruse Province, 7013, Bulgaria
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Sofia, Sofia, 1606, Bulgaria
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Sofia, Sofia, 1618, Bulgaria
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Stara Zagora, Stara Zagora Province, 6000, Bulgaria
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Varna, Varna Province, 9000, Bulgaria
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Montana, 3400, Bulgaria
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Brandýs nad Labem, Central Bohemia, 25001, Czechia
Kailera Clinical Site
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Náchod, Hradec Králové Region, 54701, Czechia
Kailera Clinical Site
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Trutnov, Hradec Králové Region, 54101, Czechia
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Brno, South Moravian, 60200, Czechia
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Holešov, Zlín, 76901, Czechia
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Hodonín, 69501, Czechia
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Pardubice, 53002, Czechia
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Uherské Hradiště, 68601, Czechia
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Falkensee, Brandenburg, 14612, Germany
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Cologne, North Rhine-Westphalia, 51069, Germany
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Essen, North Rhine-Westphalia, 45355, Germany
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Oldenburg in Holstein, Schleswig-Holstein, 23758, Germany
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Schwerin, 19055, Germany
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Grafton, Auckland, 1010, New Zealand
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New Lynn, Auckland, 0610, New Zealand
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Silverdale, Auckland, 0932, New Zealand
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Takapuna, Auckland, 0622, New Zealand
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Nawton, Hamilton, 3200, New Zealand
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Auckland, 1023, New Zealand
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Hastings, 4120, New Zealand
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Nelson, 7011, New Zealand
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Torun, Kuyavian-Pomeranian Voivodeship, 87-100, Poland
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Krakow, Lesser Poland Voivodeship, 30-033, Poland
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Siedlce, Masovian Voivodeship, 08-110, Poland
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Warsaw, Masovian Voivodeship, 00-872, Poland
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Gdynia, Pomeranian Voivodeship, 81-338, Poland
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Chorzów, Silesian Voivodeship, 41-500, Poland
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Gdynia, 81-338, Poland
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Krakow, 30-363, Poland
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Warsaw, 02-677, Poland
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Skierniewice, Łódź Voivodeship, 96-100, Poland
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Kielce, Świętokrzyskie Voivodeship, 25-338, Poland
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San Juan, 00907, Puerto Rico
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Ferrol, A Coruna, 15402, Spain
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Villamartín, Cadiz, 11650, Spain
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Madrid, 28003, Spain
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Valencia, 46014, Spain
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Truro, Cornwall, TR13LJ, United Kingdom
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Hull, East Yorkshire, HU32JZ, United Kingdom
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London, Greater London, EC1M6BQ, United Kingdom
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Leicester, Leicestershire, LE54PW, United Kingdom
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Nottingham, Nottinghamshire, NG72QW, United Kingdom
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Yate, South Gloucestershire, BS374AX, United Kingdom
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Bradford, West Yorkshire, BD96RJ, United Kingdom
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Manchester, M139WL, United Kingdom

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