Salt and genes: new study probes why some blood pressure patients are Salt-Sensitive

NCT ID NCT01426529

Ongoing Knowledge-focused Sponsor: Brigham and Women's Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how a gene called Caveolin-1 affects blood vessel function in people with mild to moderate high blood pressure. Researchers will measure kidney blood flow, artery flexibility, and blood pressure after low- and high-salt diets, as well as after an infusion of angiotensin II. The goal is to understand why some people are salt-sensitive, which could lead to better, more personalized ways to manage hypertension.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Para-aminohippuric acid and angiotensin II
What this could lead to: If successful, this study could help explain why some people with high blood pressure are salt-sensitive, potentially pointing toward more personalized treatments.
What could go wrong: This is an early-phase observational study, not a treatment trial. It is designed to gather knowledge, not to test a new therapy, so there is no direct benefit to participants.

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Conditions

The condition(s) this trial relates to.

hypertensive disorder Insulin Resistance

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPERTENSION INSULIN RESISTANCE

Contacts and locations

Locations

Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States

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