Salt and genes: new study probes why some blood pressure patients are Salt-Sensitive
NCT ID NCT01426529
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at how a gene called Caveolin-1 affects blood vessel function in people with mild to moderate high blood pressure. Researchers will measure kidney blood flow, artery flexibility, and blood pressure after low- and high-salt diets, as well as after an infusion of angiotensin II. The goal is to understand why some people are salt-sensitive, which could lead to better, more personalized ways to manage hypertension.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Para-aminohippuric acid and angiotensin II
What this could lead to
If successful, this study could help explain why some people with high blood pressure are salt-sensitive, potentially pointing toward more personalized treatments.
What could go wrong
This is an early-phase observational study, not a treatment trial. It is designed to gather knowledge, not to test a new therapy, so there is no direct benefit to participants.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Brigham and Women's Hospital
Boston, Massachusetts, 02115, United States