Brigham And Women's Hospital

This study is testing whether an oral medication called BRS201 can help control primary sclerosing cholangitis (PSC), a rare liver disease. For 8 weeks, 28 participants will take either the study drug or a placebo pill in a random order to see if it can normalize a key liver enzy…

This study tests whether teaching digital skills during a hospital stay helps Latino patients with type 2 diabetes manage their care after going home. Researchers will train patients on how to use online patient portals and telehealth services. They'll compare these patients to o…

This study is testing a new way to perform arm amputations. The goal is to help patients better control advanced prosthetic arms and regain a sense of where their limb is in space. Researchers will compare the new surgery in 10 patients to traditional amputations in 10 others. Th…

This study is testing whether using MRI scans during radiation treatment can help doctors target cancer more precisely while patients receive chemotherapy. Researchers want to see if this approach is safe and practical for treating gastric and breast cancers. The study involves 7…

This study is testing a drug called elranatamab in people with AL amyloidosis that has returned or hasn't responded to previous treatments. The first part finds the safest dose, and the second part checks how well it works at that dose. About 49 participants will receive the drug…

This study is testing whether a combination of two drugs, atomoxetine and DAW2020, can reduce the severity of obstructive sleep apnea. Researchers will compare the effects of the drugs to a placebo during overnight sleep studies. The goal is to see if this drug combination can be…

This study is testing a faster version of a non-invasive brain stimulation treatment for people experiencing depression during pregnancy or within a year after giving birth. Instead of daily treatments for 6-8 weeks, participants receive multiple sessions per day for just 5 days.…

This study is testing the safety of an experimental nasal spray called Foralumab in people with early Alzheimer's disease. The spray aims to reduce harmful inflammation in the brain by targeting the immune system. Sixteen participants will use the spray three times a week for eig…

This study is testing whether giving magnesium through an IV during surgery can help protect the kidneys of people with mesothelioma. Patients receiving a specific heated chemotherapy treatment during surgery are at risk for sudden kidney injury. Researchers will compare magnesiu…

This study is testing if a medication called sacubitril/valsartan, typically used for heart failure, can help people who are just starting dialysis. Researchers want to see if the drug helps control fluid buildup, protects any remaining kidney function, and is safe for this group…

This study is testing a new oral drug called BRS201 for adults experiencing a severe flare-up of ulcerative colitis who haven't gotten better with steroid treatment. Over 12 weeks, participants will take the study drug for 4 weeks and have several clinic visits for check-ups and …

This study is testing whether a minimally invasive procedure called lipiodol embolization, combined with physical therapy, works better than physical therapy alone for people with long-lasting, severe shoulder pain from tendon problems. The procedure involves injecting tiny parti…

This study aims to find the best treatment to help patients with multiple myeloma recover from severe kidney damage caused by the disease. It will compare three approaches: a blood-filtering procedure called plasma exchange, newer drug regimens based on daratumumab, and older dru…

This study is testing whether suddenly ill adults with conditions like infections, heart failure, or breathing problems can be safely treated at home instead of in a hospital. About 3,000 participants will receive hospital-level care at home with doctors, nurses, tests, and treat…

This study is testing if a cholesterol-lowering injection (Evolocumab) can improve blood flow to the heart in people with stable coronary artery disease. About 50 participants will receive the injection and have special heart scans before and after 12 months of treatment to measu…

This study is testing whether giving a higher daily dose of radiation over three weeks works better than the standard dose for older adults with a newly diagnosed aggressive brain tumor called glioblastoma. Researchers will compare survival, side effects, and quality of life betw…

This small, early-stage study is testing whether a weekly injection of tirzepatide, a medication currently used for diabetes and weight loss, can help people with alcohol use disorder. Twenty participants will receive either the real medication or a placebo for four weeks to see …

This study is testing if semaglutide, a medication currently used for diabetes and weight loss, can help people with opioid addiction. It will involve 46 adults who are already taking buprenorphine treatment. Participants will receive weekly injections of either semaglutide or a …

This study is testing a smartphone app designed to help older adults with multiple chronic conditions like heart failure, diabetes, and kidney disease manage their care after leaving the hospital. The goal is to see if the app can reduce complications and readmissions by providin…

This study aims to determine which of two common blood pressure medications works better to improve blood flow to the heart muscle and make the heart pump more efficiently. Researchers will compare eplerenone against chlorthalidone in 75 adults who have high blood pressure and a …

This study is testing whether colchicine, a low-cost anti-inflammatory medication, can help protect the heart in people with chronic kidney disease. It will involve about 20 participants to see if the drug improves heart function and reduces inflammation. The goal is to find a ne…

This study aims to find out which of two common types of diabetes medication is better at preventing serious heart and kidney problems in people with type 2 diabetes who are at high risk. It will enroll 6,000 participants and randomly assign them to take either an SGLT2 inhibitor…

This study is testing a new care program called OPTIONS for older adults recovering from a broken hip or leg in a nursing facility. The program provides coordinated support for exercise, healthy eating, and bone-strengthening medication during rehab and after going home. Research…

This study is testing a new, low-dose method to help people with opioid addiction start a medication called buprenorphine. Researchers want to see if giving it as a single, long-acting injection is safe and prevents severe withdrawal symptoms. They are enrolling 30 adults who are…

This study is testing if a short course of the blood pressure medication losartan can help people recover better after surgery for severe, multi-ligament knee injuries. The trial will involve 90 patients who will take either losartan or a placebo pill for 30 days after surgery. R…

This study is testing whether a computer alert in the medical record system can help doctors prescribe cholesterol-lowering medications to patients with peripheral artery disease (PAD) who are not currently on treatment. The alert reminds both doctors and patients about guideline…

This study is testing whether a dietary supplement called NMN can help protect the kidneys in older adults with type 2 diabetes. About 140 participants will take either NMN or a placebo pill twice daily for six months to see if it reduces signs of kidney damage. The main goal is …

This early-phase trial is testing whether a shorter, more intense course of radiation is safe for people with retroperitoneal sarcoma, a rare cancer in the abdomen. The study will enroll 6 adults to monitor side effects like nausea and diarrhea in the first month after treatment.…

This study is testing whether using a lower level of bicarbonate in dialysis fluid is safer for the heart during hospital stays. Researchers will compare two different bicarbonate levels in 141 adults who are on long-term dialysis and hospitalized. The goal is to see if the lower…

This study is testing a faster version of a non-invasive brain stimulation treatment for Post-Traumatic Stress Disorder (PTSD). It aims to see if giving 10 treatments per day for 5 days can reduce PTSD symptoms more effectively than a sham (fake) treatment. The study will enroll …

This study is testing a new support program to help people with HIV stay on their medication. It will compare a 'club' model—where participants pick up 6 months of medicine and get peer support—to standard clinic visits. The main goal is to see if this approach helps people maint…

This study is testing a new surgical technique for people who have already had a leg amputation. The surgery aims to modify the remaining limb to allow for better control of advanced prosthetic limbs, restore the sense of where the limb is in space (proprioception), and potential…

This study is testing a new computer tool that uses artificial intelligence to help primary care doctors safely reduce or stop high-risk medications for patients aged 65 and older. The tool learns what advice works best for each doctor and provides personalized suggestions in the…

This small pilot study is testing whether a non-invasive, painless ultrasound treatment can help control seizures in adults with epilepsy that doesn't respond to medication. Participants will receive six ultrasound sessions over three weeks while tracking their seizures. The main…

This study is testing whether adding real-time imaging guidance to lung surgery helps surgeons work more efficiently. Researchers will compare two surgical approaches for removing small lung nodules in 200 patients with suspected lung cancer. The goal is to see if the image-guide…

This study is testing whether a special type of MRI scan can accurately tell the difference between a brain tumor growing back versus harmless swelling caused by previous radiation treatment. Researchers are enrolling 101 adults with brain metastases who need surgery to remove a …

This study is testing a new, standardized method for finding lymph nodes in lung tissue removed during cancer surgery. Researchers want to see if this method helps doctors find more lymph nodes than current techniques, which could lead to more accurate cancer staging. More accura…

This study is testing whether a computer alert can help doctors identify patients with a genetic form of high cholesterol called Familial Hypercholesterolemia (FH). The alert will pop up in the patient's electronic health record during clinic visits. Researchers will compare how …

This study is testing a new type of imaging scan to see if it can accurately detect and measure scar tissue (fibrosis) in the hearts of people with cardiac amyloidosis, a serious condition where abnormal proteins build up in the heart muscle. Researchers will compare scans from 3…

This study is testing a new type of imaging scan to see if it can clearly show where prostate cancer has spread in the body. It will compare this new scan to another type of scan that is already used. The goal is to see if the new scan is a good tool for patients who are schedule…

This study is testing whether regular MRI brain scans can help find breast cancer that has spread to the brain earlier than usual. It involves patients with certain aggressive or metastatic breast cancer types where brain screening is not currently standard. The goal is to see if…

This study is testing a new needle-holder frame designed to improve the accuracy of MRI-guided prostate biopsies. It aims to see if this tool helps doctors take tissue samples more precisely from suspicious areas seen on an MRI scan. The research involves 15 men already scheduled…

This study is testing a new type of PET scan to see if it can better detect aggressive forms of advanced prostate cancer that are difficult to find with current standard scans. Researchers will enroll about 30 men with this specific type of cancer to compare the new scan against …

This study is testing a new portable X-ray machine that takes moving pictures of the lungs. It aims to see if this technology is safe and practical to use at the bedside in the Intensive Care Unit (ICU) and if it gives doctors more useful information than standard chest X-rays. R…

This study aims to see if detailed measurements of blood flow to the heart during a special MRI scan can better diagnose heart disease and predict future heart problems. It will enroll 1,000 adults with chest pain or other symptoms suggesting possible heart issues. Researchers wi…

This study is testing a new, quick ultrasound method to check for liver scarring (fibrosis) in overweight patients with fatty liver disease (NAFLD/NASH). Researchers want to see if this method, done during a routine stomach scope, is more accurate than other non-invasive tests fo…

This study is testing a computer alert system in hospital electronic records. The goal is to remind doctors to prescribe medication that helps prevent dangerous blood clots for high-risk patients after they go home. The trial will enroll 400 hospitalized patients with conditions …

This study is testing if a medication called naltrexone can help people who want to drink less or stop drinking for Dry January. It's for adults who don't have a severe alcohol problem but want to cut back. Participants will take the pill either daily or just before they think th…

This study is testing whether a specific diet can prevent or reduce the negative health effects of working night shifts, like an increased risk of diabetes. Healthy adults will stay in a research facility twice, eat provided meals, and give blood and other samples. Researchers wi…

This study is testing whether using artificial intelligence (AI) to analyze existing chest CT scans for early signs of heart artery calcium can help doctors start or adjust preventive medications sooner. It will enroll 1,500 adults aged 40-75 who have had a chest CT in the last t…

This study tests a new prevention approach for C. difficile, a serious hospital infection that causes over 29,000 deaths yearly. Researchers will identify patients carrying the bacteria without symptoms and give them a personalized prevention package. The goal is to stop these ca…

This study is testing whether playing specially designed music, sometimes with a parent's recorded voice, can help very premature babies in the hospital. Researchers want to see if this reduces the babies' stress, helps their brains develop better, and improves their language ski…

This study is testing a new pain management plan for men recovering from robotic prostate cancer surgery. The plan uses multiple non-opioid pain medications first, with opioids available only if patients call to request them. Researchers want to see if this approach safely reduce…

This study is testing whether an intravenous infusion of the hormone oxytocin can help reduce pain and the need for opioid painkillers after a minimally invasive hysterectomy. 152 women will be randomly assigned to receive either oxytocin or a placebo (saltwater) infusion during …

This study is testing a phone-based program designed to improve mental health and quality of life for people who have had a stem cell transplant. It will involve 400 survivors and compare the new program, which focuses on positive activities, to standard care. The goal is to see …

This study is a small pilot trial to see if a yoga program is a practical and acceptable way to help people manage persistent pain that lasts more than 3 months after surgery. Researchers will enroll 50 adults who have had torso surgeries and are experiencing moderate pain. They …

This study is testing whether two existing medications, pyridostigmine and low-dose naltrexone, can help improve symptoms and function for people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long COVID. It will involve 160 adults who have these conditions …

This study is testing whether testosterone replacement therapy can improve pain, energy, sexual function, and overall quality of life for men. It focuses on men with long-term chronic back pain who are taking opioid pain medications and have developed low testosterone as a side e…

This study aims to find out which of three common insomnia treatments works best for women going through perimenopause and menopause. It will compare a prescription sleep medication (daridorexant), an antidepressant often used for sleep (trazodone), and an online behavioral thera…

This small pilot study is testing whether a mindfulness meditation app is a practical and acceptable way to help people with chronic insomnia. Thirty adults will be randomly assigned to use the app with guidance, use it without guidance, or just receive standard sleep tips for fo…

This study is testing whether combining chiropractic care with virtual group support sessions can help adults 65 and older manage chronic spine pain. Researchers want to see if this combined approach is practical and acceptable to participants. The small pilot study will enroll 1…

This study is testing whether people with Parkinson's disease can safely use a special brain stimulation device at home. Participants will learn to use the device, then try it daily for a week while being monitored remotely. Researchers want to see if it's practical and safe, and…

This study is testing whether a type of behavioral therapy called Acceptance and Commitment Therapy (ACT) can help reduce the life disruption caused by chronic migraine. Researchers will compare adding 8 virtual ACT classes to standard headache treatment against standard treatmen…

This study aims to understand multiple sclerosis (MS) better by looking at how the brain uses sugar (glucose). Researchers will use a special PET scan to measure glucose consumption in the brains of 50 people, including those with different types of MS and healthy volunteers. The…

This pilot study is testing whether adults experiencing acute mental health crises like severe anxiety, depression, or psychosis can safely receive hospital-level care at home instead of in a traditional hospital. Researchers will enroll 45 carefully screened, lower-risk patients…

This study aims to better understand multiple sclerosis (MS) by using a special type of brain scan called a PET scan. Researchers will compare brain images from 8 people with MS to images from 4 healthy volunteers. The goal is to see if specific changes in the brain are linked to…

This study aims to understand how stimulating different parts of the brain with magnetic pulses affects symptoms of several mental health conditions. Researchers will enroll 180 adults with depression, anxiety, OCD, or schizophrenia to receive non-invasive brain stimulation at ra…

This study aims to understand how a specific brain circuit influences feelings of fullness and food cravings. Researchers will use a safe, non-invasive magnetic stimulation technique on the brains of 150 healthy adults while they view food images. The goal is to learn how brain a…

This research study aims to understand how a noninvasive brain stimulation technique might affect the constant hunger experienced by people with Prader-Willi syndrome. Researchers will use magnetic pulses directed at the brain (transcranial magnetic stimulation) while measuring b…

This study is testing a new computer tool that helps surgeons plan operations for complex leg fractures. The tool creates a 3D model from a patient's CT scan and simulates how different plates and screws might hold the bone together. Researchers want to see if surgeons find this …

This study aims to better understand how a protein buildup called amyloid damages the heart in people with light chain amyloidosis. Researchers will use advanced PET and MRI scans to visualize the amyloid in the heart and measure how it affects heart function and metabolism. The …

This study aims to find better ways to spot people with rheumatoid arthritis who are at high risk for heart disease before they have any symptoms. Researchers will test 120 participants with rheumatoid arthritis using two heart health markers: a blood test and a special heart sca…

This study is testing a short, 15-minute health survey for adults 65+ with early-stage lung cancer. The goal is to see if using this survey makes it easier for doctors to connect patients with helpful support services like physical therapy or nutrition counseling. Researchers wil…

This study is testing whether a special type of ultrasound therapy can improve blood flow and heart function in people with cardiac amyloidosis, a condition where abnormal proteins stiffen the heart muscle. Researchers will compare 60 patients with two types of the disease to 10 …

This study aims to understand brain inflammation in people with Multiple Sclerosis (MS) and Alzheimer's Disease by using special PET scans. Researchers will compare brain images from 250 people, including those with active MS, progressive MS, mild Alzheimer's, and healthy volunte…

This research aims to understand how healthy women's bodies and minds respond to sleep loss at different points in their menstrual cycle. The study will enroll 100 premenopausal women who will stay in a lab for about 1.5 weeks while researchers monitor their sleep patterns, hormo…

This study aims to find out if patients with a kidney drainage tube (nephrostomy) need to flush it daily with salt water to prevent clogs. Researchers will randomly assign 20 participants to either continue their normal flushing routine or to stop flushing for about three months.…

This study aims to understand how different types of food affect your body's internal clock, appetite, and energy use. Researchers will provide meals and closely monitor 24 healthy adults to see if diet patterns influence when people feel hungry and how they burn calories. The go…

This study aims to identify what factors help predict whether a person's thinking skills will improve after completing a six-month computerized brain training program. Researchers will enroll 30 adults with a past brain injury and mild thinking difficulties. They will measure cha…

This study aims to discover genetic factors that make some people develop severe chronic obstructive pulmonary disease (COPD) at a very young age. Researchers are enrolling 2,000 people who developed severe COPD before age 53, along with their family members, to collect health in…

This study aims to understand why people respond differently to GLP-1 weight loss medications like Wegovy or Ozempic. Researchers will test 30 overweight or obese adults to see if a specific genetic marker influences how much their blood pressure drops and how much weight they lo…

This study aims to understand how two key drugs, dolutegravir and rifampicin, interact in the bodies of young children who have both HIV and tuberculosis (TB). Researchers will measure drug levels in 20 children under 6 years old in Nigeria to see if a higher dose of the TB drug …

This study is trying to understand how a natural hormone might be connected to depression in women going through menopause. Researchers will give some participants a dietary supplement (pregnenolone) and others a placebo to see if it changes certain brain activities and repetitiv…

This study is testing a tiny, needle-tip-sized device that can be implanted into a head or neck cancer tumor. The device releases tiny amounts of up to 20 different drugs into the tumor for a few days before it is removed during the patient's scheduled surgery. The goal is to saf…

This study aims to understand how kidney transplant affects heart health in people with advanced kidney disease. Researchers will measure heart blood flow and function in 80 patients before and after transplant to see if improved kidney function reduces inflammation and helps the…

This study aims to better understand and identify early signs of Cerebral/Cortical Visual Impairment (CVI), a brain-based vision problem that is the leading cause of childhood visual impairment. Researchers will follow 60 high-risk infants—including those born very early or with …

This study aims to understand how developing an irregular heartbeat (atrial fibrillation) after heart surgery affects patients' quality of life. Researchers will follow 260 patients scheduled for heart surgery, asking them to complete surveys about their health and well-being bef…

This study aims to better understand how often and why patients develop an irregular heartbeat called atrial fibrillation after heart surgery. Researchers will monitor 150 patients using a small, wearable EKG patch to track their heart rhythms closely after their operation. The g…

This study aims to understand how progressive multiple sclerosis affects connections between brain cells. Researchers will use a new type of brain scan (PET) to measure these connections in 30 people with different types of MS and healthy volunteers. The goal is to see if changes…

This study explores whether people with fibromyalgia can learn to control their pain by seeing real-time images of their own brain activity. Participants use MRI brain scans for feedback while trying mental strategies, then receive either therapy or education sessions. The goal i…

Raynaud's phenomenon is a condition where the blood vessels in participants fingers and toes get too narrow when cold or stressed. This makes participants fingers and toes change colors - they might turn white, then blue, and finally red as blood flow returns. It can be painful a…