Brigham And Women's Hospital

This study tested a drug called inotersen in 31 adults with TTR amyloid cardiomyopathy, a condition where abnormal protein builds up in the heart and causes progressive damage. The drug works by reducing the production of that protein in the liver. The goal was to see if it could…

This study looked at whether a rapid blood test called ROTEM can help doctors manage transfusions better when women have severe bleeding after childbirth. The test detects early clotting problems, allowing targeted treatment. The goal was to reduce the amount of blood products ne…

This study tested a daily pill called deucravacitinib for people with palmoplantar pustulosis, a condition that causes painful, pus-filled blisters on the palms and soles. Only 3 adults with moderate-to-severe symptoms took the drug for 24 weeks. The goal was to see if it improve…

This study looked at two ways to treat paroxysmal atrial fibrillation (a type of irregular heartbeat). One method only isolates the pulmonary veins, while the other also isolates the back wall of the left atrium using a special energy called pulsed-field ablation. The goal was to…

This study tested whether shining a special narrow-band UVB light inside the mouth could help people with chronic graft-versus-host disease (cGVHD) who have painful mouth sores. Eleven participants, aged 4 and older, received the light treatment to see if it would improve their s…

This early-stage study tested whether a daily 20 mg dose of tasimelteon, a drug that mimics melatonin, could reduce dream-enacting behaviors in people with REM behavior disorder. Twenty participants tracked their sleep and symptoms using daily logs and questionnaires. The study w…

This study aimed to see if the drug ozanimod could help reduce fatigue in people with multiple sclerosis (MS). Researchers planned to track 26 adults with MS over three months using fatigue questionnaires and brain scans. The study was terminated early, so results are limited.

This study aimed to understand how a natural brain chemical called allopregnanolone influences depression in women going through perimenopause. Researchers planned to measure changes in mood and thinking patterns. However, the study was stopped early and only enrolled 2 participa…

This study tested a method to guide surgical biopsies of lymph nodes in the abdomen using real-time imaging. The goal was to make the procedure safer and more accurate. Only 11 people took part before the study was stopped early.

This study aimed to see if pairing rheumatoid arthritis patients for one-on-one support could improve their health and understanding of the disease. About 65 adults with RA were to be matched with a buddy. The study was terminated early, so results are limited.