Brigham And Women's Hospital

This study tested whether applying 0.25% timolol gel (a beta-blocker eye drop used for glaucoma) to skin grafts could improve healing and appearance after skin cancer surgery. Researchers planned to enroll 82 patients but stopped early with only 10 participants. The goal was to s…

This early-phase trial tested whether inhaling low doses of carbon monoxide could be safe for people with severe lung injury caused by sepsis. Only 5 participants were enrolled before the study was stopped early. The goal was to see if a personalized dosing formula could safely a…

This study tested a daily pill called deucravacitinib in 3 adults with palmoplantar pustulosis (PPP), a painful skin condition causing blisters on palms and soles. The goal was to see if the drug could reduce disease severity by at least 50% over 24 weeks. However, the trial was …

This study tested a drug called inotersen in 31 people with a rare condition where a faulty protein builds up in the heart, causing damage. The drug is designed to lower levels of that protein. The trial was stopped early, so it's unclear if it works, but researchers hoped to see…

This study tested whether shining a special UV light inside the mouth could help people with painful mouth sores caused by graft-versus-host disease after a stem cell transplant. Only 11 people took part, and the study was stopped early. The goal was to see if the light treatment…

This study aimed to see if the drug ozanimod could help reduce fatigue in people with multiple sclerosis (MS). Researchers planned to follow 26 adults with MS for three months, measuring fatigue using special questionnaires and brain scans. The study was terminated early, so resu…

This pilot study tested whether the sleep drug tasimelteon (Hetlioz) could reduce dream-enactment events in people with REM behavior disorder. Twenty participants took a nightly 20 mg capsule and tracked their symptoms in a daily diary. The study was terminated early, so results …

This study tested a program where people with rheumatoid arthritis (RA) were paired with a trained peer supporter for up to 6 months. The goal was to see if sharing experiences and support could improve daily function, medication adherence, and symptoms like pain and fatigue. The…

This study looked at how allopregnanolone, a natural brain chemical, affects mood and thinking in perimenopausal women with depression. Researchers gave participants either the drug brexanolone (a form of allopregnanolone) or a placebo to see how it changed their tendency to rumi…

This study looked at whether a rapid blood test called ROTEM can help doctors better manage blood transfusions in women with severe bleeding after childbirth. The test detects early clotting problems, allowing targeted treatment. The goal was to reduce the amount of blood product…

This study tested a method that uses real-time imaging to guide a minimally invasive surgical tool for taking lymph node samples from the abdomen. The goal was to see if this approach could make the biopsy more accurate and reduce risks compared to standard surgery. The study inc…