Brigham And Women's Hospital

This early-phase trial tests whether MIB-626, a drug that activates sirtuin-NAD pathways, can reach the brain and affect aging-related markers in people with mild Alzheimer's. 22 participants will take either MIB-626 or a placebo for 90 days. The study primarily checks if the dru…

This phase II trial tested whether inhaling low doses of carbon monoxide (200 ppm for 90 minutes daily for 3 days) is safe and helpful for people with acute respiratory distress syndrome (ARDS), a severe lung condition. Only 4 intubated adults participated, making this a very sma…

This study tested a drug called sacubitril/valsartan (a heart failure medication) in 45 adults who had just started hemodialysis. The goal was to see if it could improve heart function and help preserve any remaining kidney function compared to a placebo. Participants took the dr…

This study looked at 351 people with knee arthritis and a torn meniscus to see if surgery or physical therapy works better. Participants were randomly assigned to have knee surgery or follow a physical therapy program. The main goal was to measure changes in knee function and pai…

This completed study looked at two diabetes drugs, tirzepatide and sitagliptin, to see which one better prevents heart attacks, strokes, or death in people with type 2 diabetes and heart disease. Researchers analyzed data from over 49,000 patients. The goal was to learn how well …

This study tested a special digital pill and smartphone app to help HIV-negative men who have sex with men and who also have substance use disorder take their daily HIV prevention medication (PrEP) consistently. Forty participants took a PrEP pill with a sensor that recorded when…

This study tested the drug evolocumab (Repatha) in 81 kidney transplant recipients with high cholesterol. The goal was to see if it could safely lower cholesterol levels, since standard statin drugs often cause side effects in these patients. The results could lead to a better wa…

This study tested whether adding lacosamide (Vimpat) to a low dose of levetiracetam works better than a high dose of levetiracetam alone for controlling seizures. Fifty-six adults with epilepsy who had seizures on low-dose levetiracetam took part. The main goal was to see how man…

This completed trial tested a computer program that learns which reminders work best for each doctor to help them reduce high-risk medications in older patients. The study involved 70 primary care providers and over 1,200 patients aged 65 and older. The program personalized elect…

This study tested whether personalized text messages can improve medication adherence in adults with type 2 diabetes. 28 participants received either tailored or generic daily texts for 6 months. The goal was to see if custom messages help people take their diabetes pills more co…

This completed study tested whether community health workers (CHWs) and home blood pressure monitoring could help adults in rural South Africa control their high blood pressure. Over 770 participants were assigned to different levels of CHW support. The goal was to see if this ap…

This study tested whether sulfasalazine, a drug used for arthritis, can improve liver health and symptoms in people with primary sclerosing cholangitis (PSC) who also have inflammatory bowel disease. 32 adults across the US took either the drug or a placebo for a set time. Resear…

This study tested two remote care strategies to help heart failure patients get the right medications. 503 adults with heart failure were randomly assigned to either immediate medication start or education first. The goal was to see which approach led to more patients using recom…

This completed study looked at over 28,000 people with type 2 diabetes and a type of heart failure called HFpEF. Researchers compared two drugs, tirzepatide and semaglutide, to see which one better reduces the risk of death or hospitalization for heart failure. The study used rea…

This study looked at whether adding community health workers to regular care helps people with type 2 diabetes and high blood pressure in rural Mexico take their medicines as prescribed. 168 adults from local clinics took part. Researchers measured changes in blood sugar and bloo…

This large study looked at whether taking daily vitamin D or fish oil supplements could lower the risk of developing autoimmune diseases (like rheumatoid arthritis), reduce signs of inflammation in the blood, and ease chronic knee pain. Over 25,000 adults without prior cancer or …

This phase 2 trial tested whether using a CT scanner during lung surgery (VATS) helps surgeons safely remove small lung nodules. 25 patients with nodules smaller than 3 cm took part. The main goals were to see if the approach is safe and feasible. Results could lead to more preci…

This study looked at whether a low dose of the blood thinner apixaban (2.5 mg twice daily for 12 months) can safely prevent blood clots from returning in people who already had a clot triggered by a temporary risk factor. 600 high-risk adults took either apixaban or a placebo. Th…

This study looked at whether giving hospital-level care to acutely ill adults in their own homes in rural areas works well. 160 people with various conditions like infections, heart failure, or COPD took part. The goal was to see if this approach could lower costs and help patien…

This study tested a new way to perform leg amputations that connects muscles in the residual limb to act as biological motors. The goal is to allow people to control advanced prosthetic legs more naturally and with better feeling. Fifty adults needing a leg amputation due to inju…

This study tested two medications, methylergonovine and carboprost, to treat heavy bleeding after a C-section when the first drug (oxytocin) doesn't work. 100 women with postpartum hemorrhage due to a relaxed uterus were randomly assigned to one drug. Doctors measured how well th…

This study tested whether taking a magnesium glycinate supplement (480 mg daily) for 12 weeks could lower blood pressure in adults with untreated high blood pressure. 59 participants were randomly assigned to get the supplement or a placebo. The goal was to see if this simple min…

This study tested a nurse-led care management program for lupus patients at high risk of missing appointments or ending up in the emergency room. Nurses received special training on lupus and social barriers to care, then reached out to patients to help them attend rheumatology v…

This completed study tested whether eplerenone, a drug that blocks a hormone called aldosterone, improves blood flow and reduces scarring in the heart more than another drug, chlorthalidone, in 79 people with obesity and high blood pressure. Participants took one of the two drugs…

This early study tested a nasal spray called Protollin in 16 people with early Alzheimer's disease. The main goal was to see if it is safe and tolerable. The spray is designed to boost the immune system in the brain, possibly helping to clear away harmful proteins linked to Alzhe…

This study tested a digital pill and smartphone app to help people with substance use disorders take their HIV prevention medication (PrEP) consistently. Thirty HIV-negative men who have sex with men and have moderate to severe substance use disorder participated. They used a dig…

This study tested a smartphone app and a web-based dashboard to help people with rheumatoid arthritis track their symptoms between doctor visits. 190 participants used the app to answer daily questions about pain and function, while study staff monitored the data and connected pa…

This pilot study tested whether a new radioactive tracer called 18F-fluciclovine, used with a PET/CT scan, can better determine the extent of muscle invasive bladder cancer before surgery. Sixteen participants with bladder cancer received the tracer and scan before their planned …

This pilot study tested whether a radioactive tracer called F-18 florbetapir (Amyvid) can detect amyloid protein buildup in the heart using a PET scan. Researchers enrolled 23 people with known cardiac amyloidosis and a control group without the condition. The goal was to see if …

This study tested whether giving pregnant women daily vitamin D supplements (4000 IU) could prevent asthma or recurrent wheezing in their children during the first three years of life. The trial enrolled 876 pregnant women with a personal or family history of asthma or allergies.…

This study looked at whether taking daily vitamin D or fish oil supplements can help prevent bone fractures in healthy adults. Over 25,000 men and women without prior cancer or heart disease took part. Researchers tracked fractures over time and also checked if genetics or starti…

This study looked at whether taking vitamin D or fish oil supplements every day can help prevent type 2 diabetes. Over 22,000 adults without diabetes took part. Researchers tracked who developed diabetes over time to see if the supplements made a difference.

This study tested an electronic system that helps doctors create personalized exercise plans for older adults at risk of falling. Nearly 12,000 participants aged 65 and older from primary care clinics were involved. The goal was to see if tailored exercise guidance could reduce t…

This study tested whether combining a fecal microbiota transplant (FMT) with the drug bezlotoxumab could prevent repeat Clostridium difficile infections in people with inflammatory bowel disease (IBD). Sixty-one adults with at least two prior C. diff infections were randomly assi…

This study tested whether taking daily vitamin D or fish oil supplements could prevent depression in over 18,000 adults without significant mood issues at the start. Participants were followed for about 5 years. The results showed that neither supplement reduced the risk of devel…

This study tested a short in-class education program to teach children aged 7-12 how to prevent Lyme disease. The program covered personal protection, early detection, and reducing ticks around homes. Researchers compared Lyme disease cases and prevention behaviors between groups…

This large study tested whether taking daily cocoa extract (a source of flavanols) or a standard multivitamin could lower the risk of heart disease and cancer in over 21,000 older adults. Participants took the supplements or placebos for several years, and researchers tracked hea…

This large study tested whether high-dose vitamin D3 supplements could help people recently diagnosed with COVID-19 avoid severe illness and also prevent the virus from spreading to their household members. Over 2,000 participants across the U.S. and Mongolia took either vitamin …

This study tested whether applying timolol gel (a drug usually used for glaucoma) to small surgical wounds after skin cancer removal helps them heal faster and look better. Researchers compared timolol gel to plain Vaseline in 87 adults with wounds up to 1.5 cm. The main goal was…

This study tested a home-based program for people with spinal cord injury that combines leg cycling with electrical stimulation, arm exercise, and a hormone treatment. The goal was to see if this combination improves aerobic fitness, daily function, and overall health better than…

This study tested whether people with Parkinson's disease can safely use a brain stimulation device (tDCS) at home. Six participants aged 40 to 70 used the device for 20 minutes daily over a week, with video call support. The goal was to see if it's practical and safe, and to che…

This study tested whether a 5-minute session of smelling lavender essential oil can help reduce stress, anxiety, and improve satisfaction in emergency department patients. 60 adults admitted to the ER observation unit took part. Half received a lavender-scented tube to sniff, whi…

This pilot study tested whether taking naltrexone only when needed can help people who want to reduce or stop drinking during Dry January. Nineteen adults who did not have severe alcohol problems took a 50mg pill before drinking or daily as a precaution. The study checked if this…

This study tested whether giving testosterone to older women with chronic back pain and low testosterone could improve pain, physical function, and quality of life. 36 women received weekly injections of either testosterone or a placebo for several weeks. The goal was to see if t…

This study tested whether the sleep medication suvorexant (Belsomra) can reduce insomnia severity and improve metabolic health in midlife women who have both insomnia and signs of metabolic syndrome. Thirty-one healthy women aged 40-65 who were perimenopausal or postmenopausal to…

This study tested whether a type of mindfulness training called Acceptance and Commitment Therapy (ACT) could help women with frequent migraines. 75 women aged 18-65 with 4-14 migraine days per month took part. The main goal was to see if a larger study was possible, but research…

This study tested whether a smartphone-based cognitive behavioral therapy (CBT) program could help adults with psoriasis who also have depression symptoms. 30 participants used the app for 8 weeks with guidance from a coach. The goal was to see if people would engage with the pro…

This study tested a wearable device that uses mild electrical pulses to help people who have had a stroke walk more easily. Ten adults who had a stroke and lived in the community took part. The device was used in a lab and later at home to see if it could improve leg movement dur…

This study tested whether adults who have bariatric sleeve gastrectomy (a type of weight-loss surgery) can safely recover at home instead of in the hospital. Twenty-eight participants received acute care at home, including nurse and doctor visits, lab tests, and 24/7 urgent suppo…

This study tested a topical gel called MED3000 for men with erectile dysfunction that persisted 1.5 to 4 years after prostate cancer surgery. Twenty men who had nerve-sparing prostatectomy used the gel on demand. The goal was to see if it improved erectile function enough to make…

This study tested a brief, three-session program for people with chronic pain and a history of stressful or traumatic experiences. The goal was to see if the program was practical and helpful. Fifty adults participated, and the study focused on whether people would join, complete…

This study looked at whether listening to music can help lower cravings for opioids when people see drug-related cues. Twenty-eight adults with opioid use disorder, all on stable medication treatment, either listened to their favorite relaxing songs or sat in silence. Researchers…

This pilot study tested a non-drug device called Bioboosti to see if it could help people with insomnia sleep better. Twenty adults with insomnia used the device, and researchers measured changes in sleep quality and daytime sleepiness. The goal was to find a safe, drug-free opti…

This study looked at how oral opioids like oxycodone or morphine affect pain sensitivity in 35 adults with chronic low back pain. Participants received either the opioid or a placebo to measure changes in pain perception. The goal is to understand individual differences and impro…

This study tested a device that uses muscle sensors and a phone app to teach people how to relax tense muscles. It included 330 adults with chronic low back pain, recent breast surgery pain, or migraines. Half used the device plus usual care; the other half had only usual care. T…

This study tested whether a virtual yoga program could help people with chronic pain. 94 participants with pain lasting over 6 months took part in 8 weeks of remote yoga classes and daily 30-minute video-guided practice. Researchers measured how feasible the program was and wheth…

This completed pilot study tested whether a smartphone app teaching mindfulness could help people with fibromyalgia. Fifty-four adults used the app daily for pain tracking and weekly for mindfulness lessons, while a control group only tracked symptoms. The goal was to see if the …

This study tested whether a mindfulness program helps people with chronic low back pain reduce their opioid use and feel less pain interference. 121 adults who were already planning to taper their opioids were randomly assigned to either mindfulness training or a standard educati…

This study tested whether a 5-week program of positive psychology exercises—like writing a gratitude letter or recalling a past success—could help people newly diagnosed with multiple sclerosis feel more hopeful and happy. Thirty participants were split into two groups: one start…

This early study tested whether the drug acetazolamide can reduce breathing pauses during REM sleep in people with obstructive sleep apnea who cannot use a CPAP machine. Eleven participants took either the drug or a placebo for a few nights. Researchers measured breathing events …

This study tested a combination of two drugs, atomoxetine and oxybutynin (called AtoOxy), as a potential pill-based treatment for obstructive sleep apnea (OSA). 117 adults with OSA who were not using CPAP took the medication for one month. The goal was to see if the drug combo co…

This study tested whether gentle reminders (nudges) to doctors and caregivers could help reduce risky medications in people with dementia. Researchers enrolled 250 patients and their primary care providers. The goal was to see if this approach is practical and can be measured in …

This study tested whether combining two drugs—dextromethorphan (taken by mouth) and lidocaine (given through a vein)—can reduce central neuropathic pain in people with spinal cord injury. 26 adults with moderate or worse pain for at least 3 months took part. Each person received …

This study tested three doses of dextromethorphan (a common cough medicine) against a placebo to see if it could reduce nerve pain in people with spinal cord injuries. 26 adults with chronic central neuropathic pain took part. The goal was to measure pain relief and satisfaction …

This study compares two types of ultrasound-guided nerve blocks for controlling pain after mastectomy: the standard paravertebral block and a newer proximal intercostal block. Researchers want to see if the newer block offers better needle visibility, faster procedure time, and i…

This study tested whether giving mannitol during hemodialysis can prevent blood pressure drops and reduce symptoms like dizziness. Thirty-one adults prone to low blood pressure during dialysis received either mannitol or a saline placebo. The goal was to see if mannitol improves …

This study tested whether giving the sedative dexmedetomidine during lung surgery helps the lungs re-inflate better afterward. One hundred adults having a lung lobe removed received either the drug or a placebo. The goal was to see if the drug improves lung aeration and reduces c…

This study tested a short mindfulness and exposure therapy program in 13 adults with atrial fibrillation who also had high anxiety sensitivity. The goal was to see if the therapy could reduce heart-related anxiety, symptom burden, and AFib episodes. Participants attended 4-5 indi…

This small, early-stage study tested whether a dietary supplement called palmitoylethanolamide (PEA) could help people with opioid use disorder feel less stress, craving, and pain. Twelve adults already on stable medication for opioid use took PEA or a placebo for three weeks. Th…

This study looked at how healthy women in their 20s and 30s respond to sleep loss at different points in their menstrual cycle. Researchers measured alertness, sleepiness, hormone levels, and body temperature in a controlled lab setting. The goal is to understand if menstrual pha…

This study checks if a program called COPE helps Navajo people with diabetes and related health problems. The program uses community health workers to support patients and connect them with doctors. Researchers compared nearly 29,000 people who took part in COPE with those who di…

This pilot study looked at factors that predict pain and function after total knee replacement. Researchers tested a brief mindfulness-based cognitive behavioral therapy in a small group of patients and compared them to those receiving usual care. The goal was to see if this appr…

This completed study looked at insurance claims data from 70,000 people with type 2 diabetes and established heart disease to compare the heart-related risks of three diabetes drugs: tirzepatide, dulaglutide, and semaglutide. The goal was to see if any of these drugs was linked t…

This study tested whether taking two common blood thinners (aspirin and clopidogrel) for two weeks can improve blood flow in the lungs of smokers with COPD. Fifteen current or former smokers with and without COPD participated. The goal was to see changes on a special CT scan, not…

This completed study looked at over 6,000 people with advanced breast cancer to see if information from electronic health records could match the results of a famous clinical trial called PALOMA-2. The goal was not to test a new drug, but to learn whether real-world data can be t…

This completed study looked at whether information from routine medical records can produce the same results as a gold-standard clinical trial. Researchers analyzed data from 3,883 women with advanced breast cancer to see if real-world analyses could match the findings of the MON…

This completed study at Brigham and Women's Hospital used special PET scans to look at brain inflammation and chemical activity in 10 people with multiple sclerosis. The goal was to understand what causes the severe fatigue many MS patients experience. Researchers measured brain …

This study looked at whether a special, graph-based genetic counseling method helps newly diagnosed breast cancer patients better understand their risk of cancer in the other breast and make more informed surgery choices. About 400 patients participated, comparing this new approa…

This study looked at whether taking daily vitamin D and omega-3 (fish oil) supplements can improve bone density and structure in healthy adults. Researchers measured bone changes in 771 participants over time using scans and blood tests. The goal was to see if these common supple…

This study tested a computer tool that forecasts a mother's blood pressure 1 to 3 minutes ahead during a planned C-section under spinal anesthesia. 20 pregnant women participated, and doctors used the forecasts alongside their usual care to manage blood pressure. The goal was to …

This study tested whether a special PET imaging probe called [68Ga]CBP8 can measure scarring (fibrosis) in the hearts of people with cardiac amyloidosis, a rare condition where abnormal proteins build up in the heart. Researchers compared 18 participants with cardiac amyloidosis …

This study tested a machine learning algorithm to predict if a patient being cared for at home would deteriorate. Researchers used data from over 500 patients to train the algorithm and compared its alerts to traditional vital sign alarms. The goal is to catch problems earlier an…

This study tested whether getting emergency care at home is as good as going to the emergency room. 229 adults were randomly assigned to receive care at home from a paramedic and remote doctor, or to go to a standard ER. The main goal was to see how many needed an ER visit or hos…

This study looked at data from 372 patients to see if a computer program could predict who would need to be readmitted to the hospital within 30 days. Researchers used information like age and health history to train the computer model. The goal was to find patterns that could he…

This study tested a program called ED GOAL that helps older adults with serious illnesses like heart failure or cancer discuss their end-of-life wishes with doctors and family, starting in the emergency department. Researchers enrolled 141 patients and measured whether the progra…

This completed study looked at how the brain and behavior normally develop in 471 healthy children aged 6 months to 5 years living in Bahir Dar, Ethiopia. Researchers used a portable MRI scanner and age-appropriate tests to measure brain volume, early learning skills, and social …

This pilot study looked at how two different diets affect people with primary sclerosing cholangitis (PSC), a rare liver disease. Twenty adults were randomly assigned to either a vegan/low-sulfur diet or the specific carbohydrate diet for 8 weeks, with support from dietitians. Th…

This completed Phase 1 study gave hydroxocobalamin (a form of vitamin B12a) to 10 healthy adults to see how well it is tolerated. The goal was to gather safety and symptom data before testing the drug in people with ulcerative colitis, primary sclerosing cholangitis, or pouchitis…

This study looked at whether whole genome sequencing can help screen healthy babies for genetic health risks. Researchers enrolled 500 infants and their parents from three U.S. cities, took a small blood sample from each baby, and sequenced the DNA of half the group. After three …

This study looked at whether using a forward-viewing scope during a procedure called ERCP helps doctors find more important gut problems than the usual side-viewing scope. 163 adults who needed ERCP had two back-to-back exams with different scopes. The goal was to see how often t…

This study measured certain proteins in the blood and urine of 20 newly diagnosed multiple myeloma patients before and 30 days after starting daratumumab. The goal was to see if these markers could help detect early kidney injury. Participants provided samples during routine lab …

This study looked at health records from nearly 295,000 older adults with gout to see if two common gout medications, probenecid and allopurinol, affect the risk of developing dementia or Alzheimer's disease. The goal was to find out if one drug might be better at protecting the …

This study tested whether a pop-up alert in the electronic health record could remind doctors to screen for a rare but serious lung condition called chronic thromboembolic pulmonary hypertension (CTEPH) in patients who previously had a blood clot in the lungs. The trial involved …

This study looked at how the sleep hormone melatonin and a specific gene (MTNR1B) work together to control blood sugar. Researchers tested 23 healthy adults in a controlled lab setting. The goal was to understand why some people may have higher diabetes risk, which could lead to …

This study looked at how a new gel version of the antibiotic azithromycin is absorbed by the body compared to the standard pill. Eighteen healthy adults took the drug in different forms (oral gel, rectal gel, and standard pill) on separate days. The goal was to measure drug level…

This completed study looked at healthcare claims data from over 58,000 people to see if it could reproduce the results of the STEP-HFpEF DM trial, which tested semaglutide for heart failure with preserved ejection fraction in people with type 2 diabetes. Researchers compared new …

This completed study looked at whether information from healthcare claims (like insurance records) can be used to get similar results as a real clinical trial. Researchers compared people with type 2 diabetes and heart failure who started taking tirzepatide to those who started t…

This completed study looked at nearly 5,000 people with non-small cell lung cancer to see if information from electronic health records could produce the same results as a famous clinical trial called FLAURA. Researchers compared patients who started taking osimertinib to those o…

This study followed 10 adults with relapsing multiple sclerosis for 9 months to see how the drug ofatumumab affects microglia, the brain's immune cells. Researchers used special PET scans and blood tests to track changes. The goal was to understand how the drug works in the brain…

This study tested a simple tool—a standardized electronic note—to improve communication when patients are moved from one hospital to another. Researchers tracked medical errors and safety events in over 1,600 adults transferred to a large hospital. The goal was to see if better i…

This study looked at how a simulated AI helper changes the way people make decisions in tasks like deciding whether to recall a woman for more breast cancer tests. Researchers tested 12 volunteers to see how often the disease appeared affected their choices when using AI as a sec…

This study looked at 10 people hospitalized with a blood clot in the lung (pulmonary embolism). Researchers used a special 3D CT scan technique to compare lung blood vessels before and 48 hours after standard blood thinner treatment. The goal was to measure changes in blood flow …

This study looked at how reducing inflammation might lower heart disease risk in people with rheumatoid arthritis. Researchers measured heart blood flow in 74 patients before and after treatment with certolizumab, a drug that fights inflammation. The goal was to see if better con…

This study looked at how changing your sleep schedule every day affects your body's internal clock, learning, and mood. 27 healthy adults stayed in a lab for 27 days and were assigned to either a regular or irregular sleep-wake routine. Researchers measured changes in melatonin (…

This completed study at Brigham and Women's Hospital looked at how a moderately low blood sugar stress affects the brain and nervous system in 74 healthy adults. Participants underwent a procedure to lower blood sugar while brain scans measured changes in key brain regions. The g…

This study looked at how low blood sugar (hypoglycemia) affects the body's automatic nervous system, which controls heart rate and blood pressure. Researchers tested whether the drug spironolactone could block these effects in 28 healthy adults. Participants underwent controlled …

This study looked at how low blood sugar (hypoglycemia) affects the body's ability to control heart rate in people with well-controlled type 2 diabetes. Fourteen adults underwent two sessions of low blood sugar while their heart rate regulation was measured. The goal was to under…

This study looked at how two drugs, atomoxetine and oxybutynin, affect throat muscles in people with obstructive sleep apnea (OSA). The goal was to understand why the combination works better than either drug alone. 27 adults with OSA took part, and researchers measured muscle ac…

This study looked at 209 adults with moderate to severe sleep apnea to better understand how the condition affects the body. Instead of just counting breathing pauses, researchers used special measures like oxygen drops, heart rate changes, and sleep disruption. Participants used…

This study tested whether radiologists can safely skip looking at detailed 3D breast scans when a quick 2D image or an AI score suggests the case is normal. Sixteen radiologists briefly viewed each case and rated how likely it was normal, then saw the AI's opinion. The goal is to…

This study tested a new care plan for heart failure patients admitted to general medicine, who are often Black or Latinx and receive less specialized care. The plan included standard treatments, cardiology checkups, and help with transportation and follow-up. The goal was to see …

This completed study tracked 290 people who had sleeve gastrectomy surgery to see how their eating habits in the first year after surgery affected weight loss. Participants recorded their diet before surgery and at 2, 6, and 12 months after. The main goal was to measure changes i…

This study looked at how stress changes the way your nervous system controls your heart rate. Researchers gave 23 healthy adults a hormone called cosyntropin or a placebo to see if it caused delayed changes in heart rate control. The goal was to understand the link between stress…

This study looked at 130 women having laparoscopic hysterectomy with same-day discharge. Half had an active voiding trial (catheter filled and removed) and half had a passive trial (catheter removed and waited to pee). The goal was to see which method gets patients home faster. T…

This study reviewed medical records of 800 multiple sclerosis patients to see if gender, race, or socioeconomic status affected how quickly they started Ocrelizumab or how well it worked. Researchers looked at relapse rates and MRI changes over 12 to 24 months. The goal was to id…

This study followed 168 women with Multiple Sclerosis who were pregnant or planning pregnancy. Researchers collected information through phone interviews every three months during pregnancy and tracked the baby's growth for up to three years after birth. The goal was to understan…

This study looked at how a molecule called IL-5 affects different cells in the sinuses of people with nasal polyps and a related condition called aspirin-exacerbated respiratory disease. Researchers analyzed tissue samples from 30 participants to understand how IL-5 contributes t…

This study tested whether giving money to hospital employees would encourage them to be more physically active. 292 participants who exercised less than 30 minutes per week were given Fitbits and could earn up to $860 over 24 weeks by increasing their activity. The goal was to se…

This study tested ways to reduce unnecessary antibiotic use in hospitalized patients being treated for pneumonia, but who had normal breathing and oxygen levels. Over 600 patients were randomly assigned to usual care, an electronic alert, or pharmacist outreach. The goal was to s…

This completed study enrolled over 1,000 people in the Dominican Republic to track how COVID-19 spreads and how to control it. Researchers provided some households with alcohol-based hand sanitizer and monitored handwashing habits, virus exposure, and vaccine attitudes. The goal …

This study looked at how to return important genetic findings to people who had already had their genomes sequenced as part of two large heart studies. Researchers contacted 48 participants who had consented to receive results, offering them a chance to confirm and discuss any ac…

This completed pilot study tested whether training doctors to ask personalized questions (individuation) could improve care for Black and lower-income patients with rheumatic diseases like lupus and arthritis. Over 200 patients and their rheumatologists took part. The goal was to…

This study tested a mobile app called SCI-Lynx designed to help people with spinal cord injury connect with others who have similar exercise goals. Over one month, 33 participants used the app to find exercise buddies, set goals, and track progress. The goal was to see if the app…

This completed study looked at medical records from over 740,000 older adults with diabetes to see if those taking semaglutide had a lower risk of developing dementia compared to those on other diabetes drugs (DPP4 inhibitors). The goal was to find out if semaglutide might help p…

This study looked at health records from over 800,000 older adults to see if certain blood pressure drugs (propranolol or carvedilol) are linked to a lower risk of dementia compared to other similar drugs (atenolol, bisoprolol, or sotalol). The goal was to find if repurposing exi…

This study looked at why some people feel a sharp increase in pain when a numbing injection (nerve block) wears off after surgery. Researchers gave 40 healthy adults a nerve block in one arm and measured pain sensitivity as the block faded. The goal was to understand if the block…

This study looked back at over 2,300 people with known or suspected heart disease who had a stress cardiac MRI. Researchers wanted to see if certain MRI findings could predict future heart attacks or death from heart disease. The goal is to better understand how these scans can h…

This study analyzed health records from over 163,000 older adults with high blood pressure to see if one type of medication (dihydropyridine calcium channel blockers) was linked to a lower risk of developing dementia compared to another (hydrochlorothiazide). The goal was to find…

This completed study looked at medical records from over 155,000 older adults with high blood pressure. Researchers compared two types of diuretics (amiloride and triamterene) to see if one was linked to a lower risk of developing dementia or Alzheimer's disease. The goal was to …

This completed trial tested whether an on-screen electronic alert in the doctor's computer system could increase testing for chronic kidney disease (CKD) in people with type 2 diabetes. About 400 patients who hadn't had a key kidney test in the past year took part. The alert remi…

This completed Phase 1 study tested how the body processes different doses of oral buprenorphine compared to an intravenous dose. Eighteen healthy adults with past opioid use received three different doses in separate visits. Researchers measured drug levels in the blood over 24 …

This study looked at real-world medical records from over 887,000 people with type 2 diabetes, overweight, and heart risk to compare two drugs: tirzepatide and semaglutide. The goal was to see which one better prevents serious heart problems like heart attack, stroke, or death. T…

This completed study analyzed health records from over 158,000 people with type 2 diabetes to see if injectable semaglutide reduces major heart problems like heart attacks and strokes. Researchers used real-world data to mimic a previous clinical trial, aiming to learn when such …

This completed study tested whether healthcare claims data can predict the results of a major heart trial (SURPASS-CVOT) comparing two diabetes drugs, tirzepatide and dulaglutide. Researchers analyzed records from over 44,000 people with type 2 diabetes and heart disease to see i…

This study looked at whether being exposed to artificial light at night, along with not getting enough sleep, harms how the body handles blood sugar more than just lack of sleep alone. Fourteen healthy adults stayed in a lab for over a month while their sleep and light exposure w…

This study aimed to find out if certain genes make people more likely to die suddenly from a heart problem. Researchers looked at the DNA of 2,500 people to see if specific gene variations were linked to sudden cardiac death. No treatments or interventions were given; the goal wa…

This completed study compared three approaches to treating recent back or neck pain: usual care from a primary care provider, usual care plus a coordinated decision-making model (ICE), and usual care plus individualized postural therapy (IPT). Over 3,000 adults with spine pain fo…

This completed study looked at 11,000 COVID-19 patients to understand how often they develop dangerous blood clots in arteries or veins. Researchers tracked clot rates, risk factors, and outcomes over 30 and 90 days. The goal was to learn more about these complications to improve…