Brigham And Women's Hospital

This study tested whether adding a drug called bezlotoxumab to a fecal transplant (FMT) could better prevent repeat C. diff infections in people with inflammatory bowel disease (IBD). About 61 adults with both IBD and recurrent C. diff were randomly assigned to get FMT plus bezlo…

This study tested whether a combination of two drugs, atomoxetine and oxybutynin (called AtoOxy), can reduce the severity of obstructive sleep apnea (OSA) in adults who are not using CPAP. Over one month, researchers measured breathing pauses, oxygen levels, and sleep quality. Th…

This study tested whether personalized text messages can help people with type 2 diabetes take their daily pills more consistently. 28 adults who had trouble sticking to their medication schedule received either tailored or generic text messages for 6 months. The goal was to see …

This study tested two methods to reduce unnecessary antibiotic use in hospitalized patients treated for pneumonia who had normal breathing rates and oxygen levels. Over 600 patients were randomly assigned to usual care, an electronic alert, or pharmacist outreach. The goal was to…

This study tested a new approach to help people with substance use disorders take their daily HIV prevention pill (PrEP) consistently. Participants used a digital pill that tracks when it's swallowed, along with a smartphone app that provides reminders and support. The goal was t…

This study tested whether taking a low dose of the blood thinner apixaban for a longer time could prevent blood clots from returning in people who already had a clot caused by a temporary risk factor (like surgery or immobility). 600 adults at high risk for another clot were rand…

This study tested whether a smartphone app plus a monitoring system could help people with rheumatoid arthritis better manage sudden increases in disease activity (flares) between doctor visits. 190 adults with RA who owned a smartphone took part. The system used a web dashboard …

This study tested whether community health workers and home blood pressure monitors can help adults in rural South Africa better control their high blood pressure. 774 participants with high blood pressure were enrolled. The goal was to find the best way to lower blood pressure a…

This study looked at whether taking daily vitamin D or fish oil supplements could lower the risk of autoimmune diseases (like rheumatoid arthritis), reduce signs of inflammation in the blood, and ease chronic knee pain. Over 25,000 adults without prior cancer or heart disease too…

This study tested whether sulfasalazine, a drug used for arthritis and inflammatory bowel disease (IBD), can help people with primary sclerosing cholangitis (PSC), a rare liver condition. About 32 adults with both PSC and IBD took either sulfasalazine or a placebo for several mon…

This study looked at whether giving hospital-level care to acutely ill adults in their own homes in rural areas works well. 160 people with various conditions like infections, heart failure, or COPD took part. The main goal was to see if this approach could lower costs and keep p…

This study tested whether taking a magnesium supplement (480 mg daily for 12 weeks) could lower blood pressure in adults with untreated high blood pressure. 59 participants were randomly assigned to receive either magnesium or a placebo. The goal was to see if magnesium could hel…

This study tested a new way to remove small lung nodules using a CT scanner during surgery. 25 patients with small, outer-edge lung tumors were treated. The goal was to see if the approach is safe and can successfully remove the nodules. The technique aims to make surgery more pr…

This small study tested whether taking naltrexone (a medication that reduces alcohol cravings) only when needed could help people who want to cut back or stop drinking during Dry January. Nineteen adults who did not have severe alcohol problems took the pill before drinking or da…

This study looked at whether adding community health workers to regular care helps patients with type 2 diabetes and high blood pressure in rural Mexico. 168 adults took part. The goal was to see if their blood sugar and blood pressure improved and if they took their daily medici…

This study tested two medicines, methylergonovine and carboprost, to see which works better for heavy bleeding after a cesarean delivery caused by the uterus not contracting properly. 100 women who had bleeding despite standard treatment were randomly assigned to one of the two d…

This early-stage study tested a nasal spray called Protollin in 16 people with mild Alzheimer's. The main goal was to see if it is safe and tolerable. Researchers also looked at how the spray affects the immune system. This is not a cure, but a first step toward a possible new tr…

This study tested a drug called evolocumab (Repatha) to lower high cholesterol in kidney transplant recipients. High cholesterol is common after transplant and raises heart disease risk, but standard statin drugs can cause side effects in these patients. The study enrolled 81 adu…

This study looked at whether adding a low dose of lacosamide to levetiracetam works better than a high dose of levetiracetam alone for people with epilepsy who still had seizures on low-dose levetiracetam. 56 adults took part. The main goal was to see how many became seizure-free…

This study tested whether eplerenone, a drug that blocks a hormone called aldosterone, can improve blood flow to the heart and reduce scarring better than a standard blood pressure drug (chlorthalidone) in people with obesity and high blood pressure. About 79 adults took part. Th…

This study tested two remote care approaches to help heart failure patients get the right medications. Over 500 adults with heart failure took part, and the goal was to see if these strategies could increase use of recommended drugs. The focus was on optimizing existing treatment…

This pilot study tested whether a special PET scan tracer called F-18 florbetapir can safely and accurately measure amyloid protein deposits in the heart. Researchers enrolled 23 people with known cardiac amyloidosis and compared their scans to those without the condition. The go…

This study tested whether radiologists can quickly decide a mammogram is normal by looking only at the 2D image, skipping the more detailed 3D scan. 16 radiologists viewed cases for up to 5 seconds, rated their confidence, and then saw an AI opinion. The goal is to see if this "s…

This study looked at whether giving pregnant women extra vitamin D could stop their children from developing asthma or wheezing in early childhood. 876 pregnant women with a personal or family history of allergies took part. The main goal was to see if the children had asthma or …

This study tested whether taking a daily vitamin D3 supplement for 4 weeks could help people recently diagnosed with COVID-19 feel less sick and avoid needing doctor visits or hospital care. It also looked at whether the same supplement could protect their household members from …

This study tested a short in-class program to teach children aged 7-12 how to prevent Lyme disease. The program covered personal protection, early detection, and reducing ticks around homes. Researchers compared Lyme disease cases and prevention behaviors between groups to see if…

This large study looked at whether taking daily vitamin D or fish oil supplements can help prevent type 2 diabetes. Over 22,000 adults without diabetes took part. Researchers tracked who developed diabetes over time to see if these supplements lower the risk.

This large study involved over 25,000 healthy U.S. adults to see if taking daily vitamin D3 (2000 IU) and omega-3 fish oil supplements could lower the risk of bone fractures. Researchers tracked participants for several years and checked medical records for any broken bones. The …

This study tested a program that uses a computer algorithm to identify older adults at risk for falls and helps their doctors create personalized exercise plans. Over 11,000 people aged 65 and older from primary care clinics took part. The goal was to see if these tailored exerci…

This study looked at whether taking daily vitamin D or fish oil supplements could prevent depression in over 18,000 healthy adults. Participants had no major depression history and took supplements or placebos for about 5 years. The results showed that neither vitamin D nor fish …

This large study aimed to find out if taking daily cocoa extract or a standard multivitamin could help prevent heart disease and cancer in older adults. Over 21,000 men aged 60+ and women aged 65+ were randomly assigned to take either the real supplements or look-alike placebo pi…

This early study tested whether palmitoylethanolamide (PEA), a natural molecule available as a supplement, can help people with opioid use disorder feel less stress, craving, and pain. Twelve adults already on stable medication (buprenorphine or methadone) took PEA or a placebo t…

This study tested three doses of dextromethorphan, a common cough medicine, against a placebo to see if it could reduce nerve pain in people with spinal cord injuries. 26 adults with chronic central neuropathic pain took part. The goal was to measure changes in pain intensity and…

This small study tested whether people with Parkinson's disease can safely use a brain-stimulation device called tDCS at home. Six participants aged 40 to 70 used the device for 20 minutes each day for a week, with video call support. The main goal was to see if it was practical …

This study looked at over 3,000 adults with recent back or neck pain (less than 3 months) to compare three treatment approaches: usual care from a primary care doctor, care guided by a special decision-making model (ICE), and care using individualized postural therapy (IPT). The …

This study tested whether a mindfulness program could help people with chronic low back pain reduce their opioid dose and feel less pain interference. 121 adults who were already planning to taper their opioids were randomly assigned to either a mindfulness group or a standard ed…

This study tested a biofeedback device that uses muscle sensors and a smartphone app to help people with chronic low back pain, pain after breast surgery, or migraines learn to relax tense muscles. About 330 adults were randomly assigned to use the device or receive usual care. T…

This small study tested a mindfulness and exposure therapy program in 13 adults with atrial fibrillation (an irregular heartbeat) who also had high anxiety sensitivity. The goal was to see if the program could reduce heart-related anxiety, symptom burden, and AFib episodes. The a…

This study looked at whether a quick, 5-minute session of smelling lavender could help lower stress and anxiety for people in the emergency department. 60 adult patients took part, with some smelling a lavender-scented tube and others an unscented tube. The main goal was to see i…

This study tested whether a five-week program of positive psychology exercises—like writing a gratitude letter or recalling a past success—could help 30 people recently diagnosed with multiple sclerosis feel more hopeful and improve their emotional well-being and quality of life.…

This study tested whether giving mannitol (a type of sugar solution) during dialysis can help prevent low blood pressure and reduce symptoms like dizziness or nausea. It involved 31 adults who were prone to low blood pressure during their regular dialysis sessions. Each person re…

This study tested whether testosterone therapy could improve pain, physical function, and quality of life in 36 women aged 60 and older with chronic back pain, opioid use, and low testosterone. Participants received either testosterone or a placebo to compare effects on pain tole…

This study tested an 8-week smartphone-based cognitive behavioral therapy (CBT) program for 30 adults with psoriasis and mild to moderate depression. Participants used a coach-guided app to learn skills to manage their mood and skin condition. The goal was to see if the program w…

This study tested whether giving the sedative dexmedetomidine during chest surgery helps keep the lungs open and working well afterward. One hundred adults having lung surgery were randomly assigned to receive either the drug or a placebo. The main goal was to see if the drug imp…

This pilot study tested whether a smartphone app teaching mindfulness can help people with fibromyalgia manage pain and related symptoms. 54 adults used the app for 8 weeks, watching weekly videos and tracking symptoms daily. The goal was to see if the approach is feasible and re…

This study tested a mobile app called SCI-Lynx designed to help people with spinal cord injury support each other in physical activity. 33 adults who use wheelchairs used the app for one month. The goal was to see if the app was easy to use and if it helped improve exercise confi…

This study compared two types of ultrasound-guided nerve blocks for pain control in 20 women undergoing mastectomy. The goal was to see if a newer, more side-lying block (proximal intercostal) offers better needle visibility, faster setup, and improved safety compared to the stan…

This early-phase study tested whether the drug acetazolamide can reduce breathing pauses during REM sleep in people with obstructive sleep apnea. Eleven adults who could not use CPAP took part. The goal was to see if the drug improves breathing and muscle activity during sleep.

This study tested a brief, three-session program for adults with chronic pain and a history of stressful or traumatic experiences. The goal was to see if the program was practical and helpful. Fifty people took part in virtual sessions. The study focused on whether people would j…

This pilot study tested a device called Bioboosti to see if it could help people with insomnia sleep better. Twenty adults with insomnia used the device, and researchers measured changes in sleep quality and daytime sleepiness. The goal was to find a non-drug option for improving…

This study tested whether the sleep drug suvorexant could reduce insomnia severity and improve metabolic health in 31 midlife women (ages 40-65) who had insomnia and signs of metabolic syndrome. Participants took the medication for 4 weeks. The goal was to see if better sleep cou…

This study looked at whether adults who have weight-loss surgery (sleeve gastrectomy) can safely recover at home instead of in the hospital. 28 people took part, and the goal was to see if home care is just as good as hospital care. The main focus was on how long they stayed in t…

This study tested a home-based program for people with spinal cord injury that combines leg cycling with electrical stimulation, arm exercise, and a hormone treatment. The goal was to see if this approach improves aerobic capacity, muscle strength, and overall health better than …

This study tested a topical gel called MED3000 for men who have had erectile dysfunction for 1.5 to 4 years after prostate cancer surgery. 20 men used the gel on demand. The goal was to see if it improved erectile function enough to make a meaningful difference. The study is comp…

This study tested whether a combination of two drugs, dextromethorphan and lidocaine, can reduce nerve pain in people with spinal cord injuries. 26 adults received different doses of the drugs or a placebo to see which worked best. The goal was to find a better way to ease this t…

This study tested a type of mindfulness training called Acceptance and Commitment Therapy (ACT) for women who have migraines 4 to 14 days per month. Researchers wanted to see if it's possible to run a larger study and whether ACT can reduce how often migraines happen and how much…

This study looked at whether doing yoga online can help reduce chronic pain. 94 adults with pain lasting more than 6 months took part in 8 weekly virtual yoga classes and did daily 30-minute yoga videos at home. Researchers measured changes in pain intensity, how much pain interf…

This completed study looked at how oral opioids change pain sensitivity in 35 adults with chronic low back pain. Researchers measured pain responses using sensory tests to understand individual differences. The goal was to help doctors tailor opioid treatments more effectively fo…

This study looked at health records from over 887,000 people with type 2 diabetes and overweight to compare two drugs—tirzepatide and semaglutide—for preventing heart attacks, strokes, or death. The goal was not to test a new treatment but to see if analyzing real-world data can …

This study looked at medical records from over 163,000 older adults with high blood pressure to see if one type of blood pressure drug (dihydropyridine calcium channel blockers) was linked to a lower risk of developing dementia compared to another (hydrochlorothiazide). The goal …

This study looked back at data from over 2,300 people who had a stress cardiac MRI to check for heart disease. Researchers wanted to see if certain MRI findings could predict serious heart events like heart attacks or death. The goal was to better understand long-term risks for p…

This study tested two different diets—a vegan/low-sulfur diet and the specific carbohydrate diet—in 20 adults with primary sclerosing cholangitis (PSC), a rare liver disease. Participants followed their assigned diet for 8 weeks with support from dietitians. The main goal was to …

This study looked at how healthy children aged 6 months to 5 years in Bahir Dar, Ethiopia, typically develop. Researchers used a portable MRI to measure brain size and gave age-appropriate thinking and behavior tests. They also surveyed mothers about mental health, home environme…

This study looked at 800 multiple sclerosis patients to see if gender, race, or socioeconomic background affects how quickly they start Ocrelizumab treatment and how well it works. Researchers reviewed medical records from two large hospitals over four years. The goal is to ident…

This study tested a program to improve heart failure care for Black and Latinx patients who are often treated on general medicine floors instead of cardiology. The program included better treatment plans, cardiology checkups, and help with transportation. 79 patients took part to…

This study looked at how stress changes the way your nervous system works. Researchers gave healthy adults a stress hormone or a placebo and measured how well their body controls heart rate and blood pressure. The goal was to understand the link between stress and nervous system …

This study looked at how the sleep hormone melatonin and a specific gene (MTNR1B) work together to control blood sugar. Researchers tested 23 healthy adults in a controlled lab setting. The goal was to understand why some people may be more prone to diabetes based on their genes …

This study looked at how to return genetic test results to healthy adults who had already had their DNA sequenced as part of two large heart studies. Researchers tested a process to share actionable genetic findings and tracked how many people followed up with their doctors. They…

This early-stage study gave hydroxocobalamin (a form of vitamin B12a) to 10 healthy adults to see if it is safe and well-tolerated. The goal is to gather safety data before testing it as a treatment for ulcerative colitis, primary sclerosing cholangitis, and pouchitis. Participan…

This study looked at how a new gel form of the antibiotic azithromycin is absorbed in the body compared to the standard pill. Eighteen healthy adults took the drug in different forms (oral gel, rectal gel, and standard pill) on separate days. The goal was to see if the gel versio…

This study looked at medical records from over 740,000 older adults with diabetes to see if a drug called semaglutide (used for diabetes) might lower the risk of developing dementia or Alzheimer's disease. Researchers compared people taking semaglutide to those taking other diabe…

This study looked at 10 people with multiple sclerosis to understand why they feel tired. Researchers used special brain scans to measure inflammation and chemical activity. They did not test any new treatments. The goal was to learn more about what causes MS-related fatigue.

This study tested a computer tool that forecasts a mother's blood pressure 1 to 3 minutes ahead during planned C-sections under spinal anesthesia. 20 women participated, and doctors used the forecasts alongside their usual care to manage blood pressure. The goal was to see how ac…

This study tested whether a 3D CT scan technique could measure changes in lung blood vessels after standard blood thinner treatment for pulmonary embolism (blood clots in the lungs). Ten adults with acute clots had a CT scan before and 48 hours after starting blood thinners. The …

This study tested a simple idea: sending gentle reminders (nudges) to doctors and caregivers to help reduce or stop certain high-risk medications in people with dementia. Researchers worked with 250 patients aged 65 and older to see if this approach was practical and could be mea…

This study looked at a program called COPE that helps Navajo people with diabetes and other chronic conditions. The program uses community health workers to support patients and connect them with doctors. Researchers compared people in the program to those not in it to see if it …

This study looked at how inflammation and cholesterol levels relate to heart disease risk in people with rheumatoid arthritis (RA). Researchers used a special heart scan to measure blood flow. The goal was to see if lowering inflammation could improve heart health. The study incl…

This study tested whether personalized electronic health record tools, powered by a smart computer program, could help primary care doctors reduce or stop risky medications in older adults aged 65 and over. The study involved 70 doctors and 1,249 patients over 30 weeks. The goal …

This study looked at how changing sleep schedules every day affects the body's internal clock, learning, and mood. 27 healthy adults stayed in a lab for 27 days and were randomly assigned to either a regular or irregular sleep schedule. Researchers measured melatonin levels, lear…

This study tested whether getting emergency care at home is as effective as going to the emergency department. 229 adults who needed emergency care were randomly assigned to receive care at home or in the hospital. The main goal was to see if home care led to fewer emergency visi…

This completed study used health insurance claims data from over 44,000 people with type 2 diabetes and heart disease to see if it could predict results from a major clinical trial. Researchers compared two diabetes drugs, tirzepatide and dulaglutide, to see which better prevente…

This study looked at whether taking daily vitamin D and fish oil supplements can improve bone density and structure in healthy adults. Researchers measured bone changes in 771 participants over time using scans and blood tests. The goal was to see if these common supplements help…

This study measured certain proteins in the blood and urine of 20 adults newly diagnosed with multiple myeloma who were starting treatment with daratumumab. The goal was to see if these markers could help detect acute kidney injury early. Participants provided samples at the star…

This study looked at health records from over 155,000 older adults with high blood pressure to see if one type of blood pressure medication might lower the risk of developing dementia or Alzheimer's disease. Researchers compared two drugs, amiloride and triamterene, by analyzing …

This study tested whether an on-screen alert in the electronic health record could remind doctors to screen for a rare but serious lung condition called chronic thromboembolic pulmonary hypertension (CTEPH) in patients who previously had a blood clot in the lungs. About 400 adult…

This study looked at insurance claims from 70,000 people with type 2 diabetes to compare two drugs, tirzepatide and dulaglutide, on heart health. The goal was to see which drug better prevents heart attacks, strokes, or death. The study did not give any treatments but analyzed ex…

This study looked at how a mild drop in blood sugar (hypoglycemia) affects the brain and the body's automatic stress response. Researchers used brain scans to see changes in brain networks that control heart rate, blood pressure, and breathing. The goal was to understand how a ph…

This study tested a special digital pill that sends a signal when taken, along with a phone app, to help HIV-negative men who have sex with men and struggle with substance use stick to their daily HIV prevention medication (PrEP). Forty participants took the digital pill for 60 d…

This study looked at how an AI tool changes the way people make decisions when looking at medical images, like mammograms. Twelve volunteers completed a task where they decided if a woman needed further testing, with AI providing suggestions. The goal was to understand how the fr…

This study looked at whether listening to music can lower cravings for opioids when people see drug-related images. Twenty-eight adults on stable medication for opioid use disorder took part. Researchers compared cravings before and after exposure to music versus silence to see i…

This study looked at whether real-world data can be used to compare two diabetes drugs, tirzepatide and sitagliptin, for preventing heart attacks, strokes, or death in people with type 2 diabetes and heart disease. Over 49,000 participants were included, but the goal was not to f…

This study looked at health records from over 800,000 older adults to see if certain blood pressure medicines (propranolol or carvedilol) might lower the risk of developing dementia or Alzheimer's compared to other similar drugs. The goal was to find new uses for existing medicat…

This study looked at over 28,000 people with type 2 diabetes and a specific type of heart failure (HFpEF) to compare two drugs: tirzepatide and semaglutide. The goal was to see which one better prevents death or hospitalization due to heart failure. The research used existing med…

This study looked at how having low blood sugar affects the body's automatic control of the heart and blood vessels. Researchers tested 28 healthy adults to see if a drug called spironolactone could block these effects. The goal was to better understand the risks of low blood sug…

This study looked at health records from nearly 4,000 women with advanced breast cancer to see if they could recreate the results of a previous clinical trial called MONARCH-3. The goal was to learn when real-world data can be trusted to answer medical questions. No new treatment…

This study looked at health records from over 58,000 people to see if using real-world data can produce the same results as a controlled clinical trial. The researchers focused on the drug semaglutide for patients with type 2 diabetes and a type of heart failure. The goal was to …

This study looked at whether being exposed to artificial light at night, on top of not getting enough sleep, harms how the body handles sugar. 14 healthy adults spent over a month in a lab to compare sleep restriction with and without extra light. The goal was to understand how l…

This small study looked at whether taking two common blood thinners (aspirin and clopidogrel) for two weeks could improve blood flow in the lungs of current or former smokers, some with COPD and some without. Fifteen people participated in a crossover design where each person rec…

This study tested a simple tool—a standardized electronic note—to improve communication when patients are moved from one hospital to another. Over 1,600 adults transferred to a large hospital's medical, heart, cancer, or ICU units took part. The goal was to see if the note reduce…

This study tracked 11,000 COVID-19 patients to see how often they developed dangerous blood clots in arteries or veins. Researchers looked at risk factors, treatments, and outcomes over 30 and 90 days. The goal was to better understand and prevent these complications.

This study looked at data from 372 patients who were part of a home hospital program. Researchers used a computer program (machine learning) to see if it could predict which patients would need to be readmitted to the hospital within 30 days. The goal was to learn if this approac…

This study looked at 290 people who had sleeve gastrectomy surgery for obesity. Researchers wanted to see how what they ate during the first year after surgery affected their weight loss. The main goal was to measure changes in body mass index (BMI) one year after the operation.

This study tested a program called ED GOAL that helps older adults with serious illnesses like heart failure or cancer talk about their care wishes while in the emergency department. Researchers worked with 141 patients to see if the program increased their engagement in advance …

This study looked at whether certain gene changes make sudden cardiac death more likely. Researchers checked DNA from 2500 people for links to heart rhythm problems. The goal was to find genetic clues that could help predict risk, not to test a treatment.

This study looked at 163 adults having a procedure called ERCP, which examines the bile and pancreatic ducts. Doctors used two different scopes one after the other to see if a forward-viewing scope finds more important problems (like ulcers or bleeding) than the usual side-viewin…

This study looked at whether whole genome sequencing can help screen healthy babies for genetic conditions that might affect their health now or later. Researchers enrolled 500 infants and their families from three U.S. cities, took a small blood sample, and sequenced the DNA of …

This study looked at how the body processes buprenorphine, a medication used to treat opioid use disorder, when given by mouth in low doses. Healthy adults with past opioid use received single doses of buprenorphine in different forms, and blood samples were taken to measure drug…

This study looked at whether offering money can encourage people to exercise more. 292 hospital employees who were not very active wore a Fitbit for 24 weeks. Some received financial rewards for reaching step goals. The goal was to see if this approach helps people become more ph…

This study looked at how ofatumumab, a multiple sclerosis (MS) drug, affects immune cells in the brain called microglia. Ten adults with relapsing MS had special brain scans and blood tests over 9 months. The goal was to understand how the drug works in the brain, not to test if …

This study looks at over 158,000 people with type 2 diabetes to see if injectable semaglutide reduces the risk of heart attacks, strokes, or death. Researchers are using existing medical records to mimic a previous clinical trial. The goal is to learn how well real-world data can…

This study tested a training program for rheumatologists to help them break unconscious bias habits when treating Black and low-income patients. 201 patients and their doctors took part. The goal was to see if the training led to better quality care, communication, and patient tr…

This study looked at health records from nearly 5,000 people with non-small cell lung cancer to see if they could recreate the results of a famous clinical trial (FLAURA). The goal was to learn when real-world data can be trusted for research. No new treatments were given—just an…

This study followed 168 women with Multiple Sclerosis who were pregnant or planning pregnancy. Researchers conducted phone interviews every three months during pregnancy and tracked babies' growth for up to three years after birth. The goal was to understand how MS and its treatm…

This study looked at whether a special, quick form of genetic counseling (using charts and graphs) helps newly diagnosed breast cancer patients make more informed decisions about surgery. About 400 patients took part. The goal was to see if this method changes how patients unders…

This study looked at how low blood sugar (hypoglycemia) affects the body's ability to regulate heart rate in people with well-controlled type 2 diabetes. Researchers measured changes in baroreflex sensitivity—a key heart rate control mechanism—before and after inducing low blood …

This study tested a new surgical method for below- and above-knee amputations to help people use advanced prosthetic limbs more naturally. Researchers worked with 50 adults who needed a leg amputation due to injury, birth defects, or arthritis. The goal was to see if the new tech…

This study followed over 1,000 people in the Dominican Republic to understand how COVID-19 spreads and how to control it. Researchers tracked symptoms, tested for antibodies, and checked handwashing habits. The goal was to learn more about the virus and find better ways to preven…

This study tested whether a computer alert in the medical record system could prompt doctors to order a simple urine test for kidney disease in people with type 2 diabetes. Many patients with diabetes have early kidney damage but don't know it. The study involved 400 adults at on…

This study looked at why some people feel a sharp increase in pain after a local anesthetic (numbing shot) wears off, a phenomenon called rebound pain. Forty healthy volunteers received a nerve block in one arm and had their pain sensitivity measured as the block faded. The goal …

This study involved 209 adults with untreated moderate-to-severe sleep apnea. Researchers tested new ways to measure the condition's impact on the body, such as oxygen drops, heart rate changes, and sleep disruptions. The goal was to better understand why sleep apnea leads to hea…

This study tested a special PET scan to see if it can measure scarring (fibrosis) in the hearts of people with cardiac amyloidosis, a condition where abnormal proteins build up in the heart. Researchers also scanned people who had a heart attack or have hypertrophic cardiomyopath…

This study looked at medical records from nearly 295,000 older adults with gout to see if two different medications—probenecid and allopurinol—affect the risk of developing dementia or Alzheimer's disease. The goal was to find out if one drug might be better at protecting the bra…

This study looked at whether a computer program could predict when patients being treated at home might suddenly get worse. Researchers used data from 526 patients to train and test the program. The goal was to see if the program could alert doctors early, helping prevent serious…

This study looked at how two drugs, atomoxetine and oxybutynin, affect throat muscles in people with obstructive sleep apnea (OSA). 27 adults with OSA took part to help researchers understand why the combination improves breathing during sleep. The goal was not to test a new trea…

This study tested a care management program for 35 adults with lupus who were at high risk for emergency room visits or hospital stays. The program assigned a nurse manager to help patients get better outpatient care and stick with their appointments and medications. Researchers …

This study looked at how a protein called IL-5 affects different cells in the sinuses of people with nasal polyps and aspirin-exacerbated respiratory disease. Researchers analyzed tissue samples from 30 participants to understand how IL-5 contributes to immune problems. The goal …

This study looked at 130 women having a same-day hysterectomy for cancer or benign conditions. It compared an active voiding trial (where the bladder is filled and the patient tries to pee) to a passive one (just waiting to pee naturally). The goal was to see which method helps p…

This study looked at how a device that uses mild electrical pulses (FES) can help people who had a stroke walk better. Ten adults who had a stroke and lived at home took part. Researchers tested the device in a clinic and then at home to see if it could safely and effectively ass…

This study looked at whether large sets of health insurance claims can be used to get the same results as a traditional clinical trial for a heart failure drug. Researchers analyzed data from over 11,000 people with type 2 diabetes and a certain type of heart failure. The goal wa…