Which drug stops Post-Birth bleeding best? new trial has answers
NCT ID NCT03584854
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested two medications, methylergonovine and carboprost, to treat heavy bleeding after a C-section when the first drug (oxytocin) doesn't work. 100 women with postpartum hemorrhage due to a relaxed uterus were randomly assigned to one drug. Doctors measured how well the uterus tightened up. The goal is to find which drug works better to stop dangerous bleeding.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- methylergonovine and carboprost
- What this could lead to
- If one drug works better, it could become the preferred second-line treatment for severe bleeding after childbirth, improving outcomes for mothers.
- What could go wrong
- This is a small, completed trial with only 100 participants, so results may not apply to all women. The drugs also have side effects like high blood pressure or breathing problems.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Brigham and Women's Hospital
Boston, Massachusetts, 02115, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Medical glue vs. internal bleeding: a new hope?
- Which drug stops Post-Birth bleeding better? a Head-to-Head test
- Could a simple calcium injection prevent dangerous bleeding after childbirth?
- Blood-Clotting showdown: which device best guides bleeding care in High-Risk patients?
- Simple C-Section techniques could slash postpartum bleeding risk