Massive diabetes trial aims to find which drug saves hearts and kidneys best

NCT ID NCT05390892

Recruiting now Disease control Sponsor: Brigham and Women's Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two common diabetes drug classes—SGLT2 inhibitors and GLP-1 receptor agonists—to see which better prevents heart attacks, strokes, kidney failure, and death in 6,000 people with type 2 diabetes and heart disease or high risk. Participants are randomly assigned to one drug class and followed for years. The goal is to guide doctors on the best treatment to reduce serious complications.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: SGLT2 inhibitors (empagliflozin, dapagliflozin, canagliflozin) or GLP-1 receptor agonists (dulaglutide, liraglutide, semaglutide)
What this could lead to: If it works, this could show which drug class is better at preventing serious heart and kidney complications in people with type 2 diabetes.
What could go wrong: This is a large, late-stage trial, but it's open-label (no placebo), so results may be influenced by patient or doctor expectations. Also, individual responses vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atherosclerotic cardiovascular disease type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ASCVD TYPE2DIABETES

Contacts and locations

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Locations

Atrium Health Family Medicine Research Department
RECRUITING

Charlotte, North Carolina, 28207, United States
Brigham and Women's Hospital
RECRUITING

Boston, Massachusetts, 02115, United States
Duke University Hospital
RECRUITING

Durham, North Carolina, 27710, United States
Eastside Clinical Research Associates
RECRUITING

Los Angeles, California, 90022, United States
Essentia Health
RECRUITING

Duluth, Minnesota, 55805, United States
Family Care Center at Kent Hospital
RECRUITING

Pawtucket, Rhode Island, 02860, United States
Geisinger Medical Center
RECRUITING

Danville, Pennsylvania, 17821, United States
Herman Clinical Research
RECRUITING

Suwanee, Georgia, 30024, United States
HonorHealth Research & Innovation Institute
RECRUITING

Scottsdale, Arizona, 85258, United States

Contact Email: •••••@•••••
Johns Hopkins School of Medicine
RECRUITING

Baltimore, Maryland, 21205, United States
Kendall South Medical Center, Inc
RECRUITING

Miami, Florida, 33185, United States
Kidney and Hypertension Specialists, PLLC
RECRUITING

Manassas, Virginia, 20110, United States

Contact Email: •••••@•••••
Longwood Research LLC
RECRUITING

Huntsville, Alabama, 35801, United States
MedStar Health Research Institute - Good Samaritan Hospital
RECRUITING

Baltimore, Maryland, 21239, United States
MedStar Union Memorial Hospital
RECRUITING

Baltimore, Maryland, 21218, United States
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Medical University of South Carolina
RECRUITING

Charleston, South Carolina, 29425, United States
NSC Research, Inc.
RECRUITING

Johns Creek, Georgia, 30024, United States

Contact Email: •••••@•••••
Naomi Berrie Diabetes Center at New York Presbyterian-Columbia University
RECRUITING

New York, New York, 10032, United States
North Dallas Research Associates
RECRUITING

McKinney, Texas, 75069, United States
Oregon Health & Science University
RECRUITING

Portland, Oregon, 97239, United States
Premier Internal Medicine Associates of Houston
RECRUITING

Katy, Texas, 77493, United States

Contact Email: •••••@•••••
Rush University Medical Center
RECRUITING

Hinsdale, Illinois, 60521, United States
South Carolina Clinical Research, LLC
RECRUITING

Orangeburg, South Carolina, 29118, United States
South Florida Research Solutions, LLC
RECRUITING

Pembroke Pines, Florida, 33028, United States
Temple University Lewis Katz School of Medicine
RECRUITING

Philadelphia, Pennsylvania, 19140, United States
UMass Chan Medical School
RECRUITING

Worcester, Massachusetts, 01655, United States
University of Illinois Chicago
RECRUITING

Chicago, Illinois, 60612, United States
University of Iowa
RECRUITING

Iowa City, Iowa, 52242, United States
University of Kansas Medical Center
RECRUITING

Fairway, Kansas, 66205, United States
University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of Minnesota
RECRUITING

Minneapolis, Minnesota, 55455, United States
University of Missouri-Columbia
RECRUITING

Columbia, Missouri, 65212, United States
University of Nebraska Medical Center
RECRUITING

Omaha, Nebraska, 68198, United States
Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37232, United States
Wooster Heart Group
RECRUITING

Wooster, Ohio, 44691, United States

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