MIGRAINE

This study tested whether a daily 10-minute biofeedback session using a phone app and sensors could help prevent migraine attacks. 279 adults with episodic migraines were assigned to either use the app daily for 12 weeks or to a waitlist group that tracked headaches. Researchers …

This study aimed to check the long-term safety and effectiveness of a monthly injection called fremanezumab for preventing migraines in children and teenagers aged 6 to 17. It involved 506 young participants who had already been in related studies, tracking them for up to 7 years…

This study tested whether monthly injections of a drug called fremanezumab could help prevent chronic migraines in children and teenagers aged 6 to 17. Researchers compared the drug to a placebo (inactive shot) in 292 participants to see if it safely reduced the number of migrain…

This Phase 3 study tested whether rimegepant, taken every other day, could help prevent migraines in Chinese adults with frequent episodes. The 787 participants were randomly assigned to receive either the active drug or a placebo pill for 12 weeks, with some continuing for anoth…

This study tested whether a medication called rimegepant, taken regularly, could help prevent migraines in Japanese adults who get them frequently. Nearly 500 participants were randomly assigned to receive either rimegepant or a placebo pill for 12 weeks to see if it safely reduc…

This study tested the long-term safety of taking rimegepant daily to prevent episodic migraine attacks. Researchers followed 441 adults with frequent migraines for up to a year to monitor side effects and how well they tolerated the medication. The goal was to understand the risk…

This study aimed to check the long-term safety of a migraine prevention medicine called eptinezumab. It involved 160 Japanese patients with migraine who received the medicine for 60 weeks, followed by 8 weeks of safety monitoring. The main goal was to see how well patients tolera…

This large, completed study tested whether a medication called eptinezumab could help prevent migraines in adults who get them very frequently. Nearly 1,000 participants with chronic migraine received either the drug at one of two doses or a placebo injection to see which was bet…

This study tested whether a monthly injection called erenumab could safely reduce the number of migraine days for adults with chronic migraine. Over 550 participants were randomly assigned to receive either the real injection or a placebo shot for 12 weeks. The main goal was to s…

This study tested whether a monthly injection called erenumab could safely reduce the number of migraine days in children and teenagers with chronic migraine. It involved 284 participants aged 6 to 18 who had frequent migraines. The goal was to see if the treatment was better tha…

This study tested whether a drug called fremanezumab, given as a shot under the skin, could safely prevent migraines in Chinese adults. About 365 people with frequent migraines received either the drug monthly, quarterly, or a placebo for 12 weeks, followed by a period where ever…

This study tested if adding a preventive migraine drug called eptinezumab to a brief educational program helps adults who have frequent migraines and also overuse pain medications for headaches. Over 600 participants were randomly assigned to receive either eptinezumab or a place…

This study tested the safety of a new migraine injection (Lu AG09222) when taken with an existing oral migraine medication (ubrogepant). It involved 43 adults with a history of migraine to see if the combination caused any new or worsening side effects. This was an early-stage tr…

This study tested whether taking the migraine prevention medication rimegepant daily or every other day was better than a placebo at reducing the number of migraine days. Over 1,400 adults with episodic migraine participated. The goal was to find the most effective and safe dosin…

This study tested a two-drug combination called AXS-07 for treating migraine attacks. It was for adults who had tried a common type of migraine pill (a CGRP inhibitor) and didn't get enough relief. Participants took the study drug at home for up to 8 weeks to treat up to four of …

This study tested whether a single dose of a new oral medication called AXS-07 could stop migraine pain and the most bothersome symptom within two hours. It involved 302 adults with migraines who were randomly assigned to receive either the medication or a placebo pill when a mig…

This study tested a wearable device called Nerivio for treating migraine attacks in children aged 6 to 11. The device, worn on the upper arm, uses gentle electrical pulses to target nerves and aims to relieve migraine pain and symptoms. Researchers monitored nearly 300 children t…

This study tested whether a mindfulness-based therapy called Acceptance and Commitment Therapy (ACT) could help reduce migraine frequency and disability. Researchers enrolled 75 women with frequent episodic migraines and randomly assigned them to either receive the ACT training o…

This study tested whether a biofeedback device could help people manage different types of chronic pain. 330 adults with chronic low back pain, recent breast surgery, or migraines were randomly assigned to either use the device with guidance or continue their usual care. The devi…

This study looked at whether using the Nerivio device to treat migraine attacks is safe for pregnant women and their babies. Researchers compared health outcomes for 145 women who used Nerivio during pregnancy to women who did not. The goal was to see if using the device affected…

This study tested how well lasmiditan works to stop migraine attacks and what side effects people experienced when using it in their daily lives. Researchers followed 100 people with migraines who took lasmiditan tablets during at least four migraine attacks over three months. Th…

This study looked at whether giving children intravenous (IV) fluids alone could help reduce severe migraine pain when they visit the emergency department. Researchers wanted to see if the expectation of getting medication influenced pain relief. The goal was to find a simpler, f…

This study tested whether a device called Mi-Helper could safely and effectively treat migraine attacks at home. The device works by delivering cooling air through the nose. Researchers compared the real device to a fake version in 156 adults with migraines to see if it could rel…

This study tested whether adding foot reflexology to usual migraine care helps reduce pain and fatigue. 78 adults with migraine were split into two groups: one received 10 sessions of foot reflexology, while the other continued their usual treatment only. Researchers measured cha…

This study tested whether praying could help people with migraines better tolerate pain and feel less anxious or depressed. It compared the effects of prayer to reading a neutral text in 100 participants, half with migraines and half without. Researchers measured pain thresholds …

This study aimed to see how well and how safely the medication Rimegepant works for treating migraine attacks in real-world settings. It followed 173 adults with migraines for a year as they used the medication when needed. Researchers tracked how quickly pain eased, how often mi…

This study tested if a new under-the-tongue medication called MTX101 could safely and effectively treat migraine pain when it starts. 78 adults with a history of migraines took either the drug or a placebo pill for two separate migraine attacks. Researchers compared the results t…

This small pilot study tested whether a 12-week telehealth program could help people manage migraines. Twenty participants with frequent migraines used a mobile app diary, online educational materials, and had video sessions with a provider. The main goal was to see if this appro…

This study tested whether combining a gentle nerve stimulation device with stress reduction training could help reduce migraine pain. Researchers enrolled 193 adults with migraines and some healthy volunteers to compare their brain scans. The goal was to see if this 8-week combin…

This study tested whether injecting a numbing medicine (lidocaine) into a specific acupuncture point in the neck is a safe and effective way to treat migraines. Researchers compared weekly injections to a daily pill (propranolol) in 30 adults with frequent migraines. They measure…

This study tested a new, wearable device that uses gentle electrical pulses on the head or neck to try to stop migraine pain. 160 adults with frequent migraines tried the device during three separate migraine attacks, comparing real stimulation to a fake (sham) treatment. The mai…

This study tested a new medicine called BHV-2100 to see if it can safely and effectively stop migraine headaches. About 647 people with migraines received either the drug or a placebo pill when a migraine started. Researchers measured how many people were pain-free and free of th…

This study tested whether combining posture correction exercises with gentle, guided neck movements could help people with migraines. It involved 44 adults with frequent migraines who were not taking medication during the trial. Researchers measured changes in their pain levels, …

This is a very early study to check if a new nasal spray called PRT-064040 is safe for people. It involved 80 healthy Chinese adults who received either the spray or a placebo. The main goal was to see what side effects might occur and to measure how the drug is absorbed and proc…

This study analyzed survey data from over 1,300 people with migraines to compare two common acute treatments: rimegepant (like Nurtec) and triptans. Researchers looked at which treatment led to better patient satisfaction, quality of life, and less impact on work and daily activi…

This study tested whether an AI-powered voice chatbot could help women in Hong Kong track their migraine symptoms more easily and accurately than traditional paper diaries. 49 women with migraines used both the chatbot and a paper diary for one month each to record their symptoms…

This study aimed to understand how mood disorders, anxiety, and migraines run in families. Researchers interviewed nearly 2,000 participants, including children and adults, to identify patterns and risk factors across generations. The goal was to gather knowledge to help improve …

This study aimed to see if being sensitive to smells (called osmophobia) is a reliable sign that someone has migraines rather than tension headaches. Over six months, 210 people with either migraine or tension headaches tracked their headaches and smell sensitivity in special dia…

This study aimed to create a computer program that could predict if someone would have a migraine the next day. Over 53,000 people who use a migraine treatment app provided daily information about their symptoms, location, and weather. Researchers used this data to train a machin…

This study aimed to understand if people with migraines have differences in neck stability, neck position sense, and body awareness compared to people without migraines. Researchers enrolled 64 participants, half with migraines and half healthy controls, to complete questionnaire…

This study aimed to understand how common migraines are in women experiencing infertility and whether the hormone changes during in vitro fertilization (IVF) treatment affect migraine headaches. Researchers surveyed 137 women at a fertility clinic, asking about their headache his…