Migraine and heart risk: fatty meal test reveals clues

NCT ID NCT03081390

Ongoing Knowledge-focused Sponsor: University of Pennsylvania Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study looks at how a high-fat, high-carb meal affects inflammation and stress responses in women with migraine compared to healthy women. Thirty women aged 18-35, with and without migraine, will have blood tests and pain tests after eating a test meal. The goal is to understand why women with migraine have a higher risk of heart disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could help explain why women with migraine have higher heart disease risk, pointing to new prevention strategies.
What could go wrong: This is a small, early-stage observational study with only 30 participants, so results may not apply to all women with migraine. It does not test a treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

migraine disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MIGRAINE

Contacts and locations

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Locations

Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104, United States
University of Pennsylvania

Philadelphia, Pennsylvania, 19004, United States

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