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Migraine and heart risk: fatty meal test reveals clues

NCT ID NCT03081390

Knowledge-focused Sponsor: University of Pennsylvania Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study looks at how a high-fat, high-carb meal affects inflammation and stress responses in women with migraine compared to healthy women. Thirty women aged 18-35, with and without migraine, will have blood tests and pain tests after eating a test meal. The goal is to understand why women with migraine have a higher risk of heart disease.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help explain why women with migraine have higher heart disease risk, pointing to new prevention strategies.
What could go wrong
This is a small, early-stage observational study with only 30 participants, so results may not apply to all women with migraine. It does not test a treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2017

Expected to finish

Jun 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 35 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria (all): * Female 18-35 years of age, inclusive * BMI 18.5-24.9 kg/m2, inclusive * BMI ≥30 kg/m2 Inclusion Criteria (cases only): * Diagnosis of migraine per ICHD-3-beta (1-10 migraine days per month) Exclusion Criteria (all): * Smoking (current or former) * Chronic use of medications, including oral contraceptives * Major medical or psychiatry illness (e.g. diabetes, fibromyalgia, major depression/anxiety) * Pregnant or nursing * Allergies or sensitivity to any of the ingredients of the meal * Inability to fast for 10 hours and/or abstain from caffeine intake for 24 hours * Treatment with antibiotics or steroids within the previous 3 months * Treatment with NSAIDs within the previous 1 week Exclusion Criteria (controls only): * Migraine headaches, or headaches other than tension-type headaches with a frequency of 1 or fewer days per month

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Conditions

The condition(s) this trial relates to.

migraine disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Migraine

Contacts and locations

Locations

  • Children's Hospital of Philadelphia

    Philadelphia, Pennsylvania, 19104, United States

  • University of Pennsylvania

    Philadelphia, Pennsylvania, 19004, United States

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