New hope for chronic face pain: lidocaine and ketamine combo tested

NCT ID NCT07250867

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study compares two pain-relieving drugs, lidocaine and ketamine, given through an IV, to see if they can reduce stubborn face or mouth pain. About 105 adults with pain that hasn't responded to other treatments will receive one or both drugs. The goal is to measure pain relief and safety over 6 months.

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Conditions

The condition(s) this trial relates to.

Facial Pain malignant otitis externa migraine disorder persistent idiopathic facial pain temporomandibular joint disorder trigeminal neuralgia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.