Persistent idiopathic facial pain

This trial tests whether a new type of deep brain stimulation (DBS) can better relieve chronic pain that hasn't responded to other treatments. Unlike traditional DBS, which delivers constant stimulation, this approach uses a device that adapts stimulation in real time based on br…

This study tests a combination of four drugs (iparomlimab, tuvonralimab, apatinib, and irinotecan) in 39 adults with advanced AFP-producing stomach or gastroesophageal junction cancer that has worsened after initial immunotherapy and chemotherapy. The goal is to see if this new m…

This study tests whether directional deep brain stimulation (DBS) can reduce pain in people with neuropathic dental pain (phantom tooth pain). Five adults who have not responded to standard treatments will receive DBS and try different stimulation settings. The goal is to find wh…

This study tests a type of talk therapy called Pain Reprocessing Therapy (PRT) for people with chronic face pain that has no clear physical cause. The goal is to see if changing how the brain processes pain can lower pain intensity and improve quality of life. Sixty adults will b…