Scientists probe sonic hedgehog pathway for clues to brain AVM treatment
NCT ID NCT07676721
First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time
Summary
This study investigates the role of the Sonic Hedgehog signaling pathway in brain arteriovenous malformations (AVMs), abnormal tangles of blood vessels that can cause bleeding or stroke. Researchers will analyze leftover brain tissue from 20–30 adults undergoing AVM surgery and compare it to non-pathological tissue from 10–15 epilepsy surgery patients. Using advanced techniques like gene and protein analysis, they aim to identify molecular differences that could point to new drug targets for this condition.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- What this could lead to
- If successful, this research could identify new drug targets for treating brain arteriovenous malformations, potentially leading to therapies that reduce the need for surgery.
- What could go wrong
- This is an early-stage observational study analyzing tissue samples, not testing a treatment. The findings may not translate into effective therapies, and animal model studies may not predict human outcomes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for BRAIN ARTERIOVENOUS MALFORMATIONS (AVMS) are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Rome, Rome, 00168, Italy