Lab-Grown cells could seal bile leaks without more surgery
NCT ID NCT07214649
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial tests whether a patient's own bile duct cells, grown into tiny organoids in a lab, can be used to patch persistent bile leaks after liver surgery. Researchers will take a small bile duct sample during surgery, store it, and if a leak doesn't heal with standard treatments, they'll grow organoids and deliver them to the leak site. The study includes 25 adults and aims to see if the leak closes without further intervention.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
patient-derived bile duct organoids
What this could lead to
If it works, this could provide a new way to repair stubborn bile leaks without repeated surgeries or transplants.
What could go wrong
This is a small early-phase trial with only 25 people. The organoids may not engraft or fully close the leak, and long-term safety is unknown.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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